4-Bromothiophene-2-carboxaldehyde

Product Name: 4-Bromothiophene-2-carboxaldehyde
CAS No.: 18791-75-8
Chemical Name: 4-Bromothiophene-2-carboxaldehyde
Synonyms: 4-BROMOTHIOPHENE-2-CARBALDEHYDE;4-BROMO-2-THIOPHENECARBOXALDEHYDE;TIMTEC-BB SBB000293;4-Bromo-2-thiophene;LABOTEST-BB LT00112358;4-BROMO-2-FORMYLTHIOPHENE;3-Bromo-5-formylthiophene;4-BROMOTHIOPHENE-2-ALDEHYDE;4-Bromthiophen-2-carbaldehyd;4-BROMO-2-THIOPHENECARBALDEHYDE
CBNumber: CB3771198
Molecular Formula: C5H3BrOS
Formula Weight: 191.05
MOL File: 18791-75-8.mol

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4-Bromothiophene-2-carboxaldehyde Property

Melting point:: 44-46 °C (lit.)
Boiling point:: 114-115 °C/11 mmHg (lit.)
Density: 1.770 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: soluble in Methanol
form: Powder or Granules
color: White to beige
Sensitive: Air Sensitive
BRN: 108455
InChI: InChI=1S/C5H3BrOS/c6-4-1-5(2-7)8-3-4/h1-3H
InChIKey: PDONIKHDXYHTLS-UHFFFAOYSA-N
SMILES: C1(C=O)SC=C(Br)C=1
CAS DataBase Reference: 18791-75-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-20/21/22
Safety Statements: 22-24/25-36/37/39-26-36
WGK Germany: 3
F: 10-23
TSCA: N
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 283452
Product name: 4-Bromo-2-thiophenecarboxaldehyde
Purity: 90%
Packaging: 5g
Price: $56.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 283452
Product name: 4-Bromo-2-thiophenecarboxaldehyde
Purity: 90%
Packaging: 25g
Price: $186.9
Updated: 2025/07/31

TCI Chemical

Product number: B2827
Product name: 4-Bromothiophene-2-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: B2827
Product name: 4-Bromothiophene-2-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 25g
Price: $119
Updated: 2025/07/31

TRC

Product number: B688110
Product name: 4-Bromo-2-thiophenecarboxaldehyde
Packaging: 50g
Price: $1230
Updated: 2021/12/16

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4-Bromothiophene-2-carboxaldehyde Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

4-Bromothiophene-2-carboxaldehyde has been used:

as building block for the synthesis of tetrahydroisoquinolinones
in the synthesis of 3-[(4-bromo-2-thienyl)methylenehydrazinocarbonyl]-1H-1,2,4-triazole

Application

4-Bromothiophene-2-carboxaldehyde is an important and commonly used intermediate in medicinal chemistry.

Synthesis

872-31-1

68-12-2

18791-75-8

930-96-1

General procedure: a THF solution of 1 M NaHMDS (8.8 mL, 8.8 mmol) was slowly added dropwise to the substrate (6.8 mmol) at 0°C. The reaction mixture was stirred for 30 min at 0 °C, then a solution of anhydrous THF (2 mL) with electrophilic reagent (8.3 mmol) was slowly added and stirring was continued for 3 h at 0 °C. Upon completion of the reaction, the reaction was quenched with saturated NH4Cl solution (5 mL) and diluted with hexane (20 mL). The organic layer was separated and washed with 15 wt% NaCl aqueous solution (10 mL) and subsequently concentrated to give the crude product. The product was purified by fast chromatography using a silica gel column pretreated with Et3N and 0.1% Et3N/4.9% EtOAc/95% hexane as eluent.

Toxicity evaluation

4-Bromothiophene-2-carboxaldehyde has acute oral toxicity and acute dermal toxicity, it causes skin corrosion/irritation and serious eye damage/eye irritation.

References

[1] Tetrahedron Letters, 2012, vol. 53, # 2, p. 166 - 169
[2] Tetrahedron Letters, 2012, vol. 53, # 2, p. 166 - 169

4-Bromothiophene-2-carboxaldehyde Preparation Products And Raw materials

Raw materials

2-Thiophenecarboxaldehyde Aluminum chloride Bromine Dichloromethane

Preparation Products

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4-Bromothiophene-2-carboxaldehyde Suppliers

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View Lastest Price from 4-Bromothiophene-2-carboxaldehyde manufacturers

Shandong Vital Biotechnology Co., Ltd.

Product: 4-BroMo-2-thiophenecarboxaldehyde 18791-75-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100tons
Release date: 2025-11-20

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Bromothiophene-2-carboxaldehyde 18791-75-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-09

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Bromothiophene-2-carboxaldehyde 18791-75-8
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2024-08-19

18791-75-8, 4-Bromothiophene-2-carboxaldehydeRelated Search:

2-Thiophenecarboxaldehyde Tetrahydrothiophene Cephalothin sodium Thifensulfuron 3-Thiophenecarboxaldehyde Dibenzothiophene Bromine 5-BROMOTHIOPHENE-2-CARBOXALDEHYDE,2-BROMOTHIOPHENE-5-CARBOXALDEHYDE 5-BROMOTHIOPHENE-2-CARBOXALDEHYDE OXIME 3-Bromothiophene-2-carboxaldehyde, GC 97%,3-BROMOTHIOPHENE-2-CARBOXALDEHYDE 98%,3-Bromothiophene-2-carboxaldehyde, 95%+,3-BROMOTHIOPHENE-2-CARBOXALDEHYDE 4,5-DIBROMOTHIOPHENE-2-CARBOXALDEHYDE 1-(4-BROMO-2-THIENYL)ETHAN-1-ONE 3-BROMOTHIOPHENE-2-CARBOXALDEHYDE DIETHYL ACETAL METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE 4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID METHYL 4,5-DIBROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE METHYL4,5-DIBROMOTHIOPHENE-2-CARBOXYLATE METHYL 4-BROMO-3-METHOXYTHIOPHENE-2-CARBOXYLATE

4-Bromo-2-thiophenecarboxaldehyde,90%

4-BroMo-2-thiophenecarboxaldehyde, 90% 5GR

2-Thiophenecarboxaldehyde, 4-bromo-

4-Bromo-2-formylthiophene, 4-Bromo-2-thenaldehyde

4-BROMOTHIOPHENE-2-CARBALDEHYDE

4-Bromothiophene-2-carboxaldehyde 98%

4 - broMine - 2 - thiophene forMaldehyde

4-Bromothiophene-2-carboxaldehyde,96%

4-BROMOTHIOPHENE-2-CARBOXALDEHYDE

4-BROMOTHIOPHENE-2-ALDEHYDE

4-BROMO-2-THIOPHENECARBALDEHYDE

4-BROMO-2-THIOPHENECARBOXALDEHYDE

4-BROMO-2-FORMYLTHIOPHENE

4-Bromothiophen-2-carboxaldehyde

TIMTEC-BB SBB000293

LABOTEST-BB LT00112358

Bromothiophene-2-carboxaldehyde

2-THIOPHENE-4-BROMOCARBOXALDEHYDE

4-Bromo-2-thiophene

4-BROMO-2-THIOPHENECARBOXALDEHYDE 90%

4-Bromothiophene-2-carboxaldehyde &gt

4-Bromothiophene-2-carboxaldehyde ISO 9001：2015 REACH

4-Bromthiophen-2-carbaldehyd

3-Bromo-5-formylthiophene

18791-75-8

C5H3BrOS

C5H3OBrS

ALDEHYDE

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Thiophenes

Halogenated Heterocycles

Heterocyclic Building Blocks

Thiophenes

ThiophenesBuilding Blocks

Aldehyde

Building Blocks

Thiophene

Aldehydes

blocks

Bromides

Heterocycles

Carbonyl Compounds

Thiophene&Benzothiophene