6-AMINOPHTHALIDE

Product Name: 6-AMINOPHTHALIDE
CAS No.: 57319-65-0
Chemical Name: 6-AMINOPHTHALIDE
Synonyms: 6-Aminoisobenzofuran-1(3H)-one;1(3H)-Isobenzofuranone, 6-amino-;6-AMINO-1,3-DIHYDROISOBENZOFURAN-1-ONE;RMA-283;6-Aminophtalide;6-AMINOPHTHALIDE;BUTTPARK 33\04-93;6-Aminophthalide,95%;6-Aminophthalide 97%;6-AMINOISOBENZOFURAN-1-ONE
CBNumber: CB3771916
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 57319-65-0.mol

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6-AMINOPHTHALIDE Property

Melting point:: 183 °C
Boiling point:: 420.2±45.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 3.88±0.20(Predicted)
Appearance: White to yellow Solid
Water Solubility: Soluble in water 1360 mg/L 25°C.
InChI: InChI=1S/C8H7NO2/c9-6-2-1-5-4-11-8(10)7(5)3-6/h1-3H,4,9H2
InChIKey: ZIJZDNKZJZUROE-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC(N)=C2)CO1
CAS DataBase Reference: 57319-65-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
RIDADR: UN2811
Hazard Note: Irritant
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S745197
Product name: 6-AMINOPHTHALIDE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $143
Updated: 2025/07/31

Sigma-Aldrich

Product number: S745197
Product name: 6-AMINOPHTHALIDE
Purity: Aldrich
Packaging: 5mg
Price: $139
Updated: 2024/03/01

TRC

Product number: A616080
Product name: 6-Aminophthalide
Packaging: 1g
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: J96575
Product name: 6-Aminophthalide
Packaging: 5g
Price: $240
Updated: 2021/12/16

Apolloscientific

Product number: OR3916
Product name: 6-Aminophthalide
Purity: 95%
Packaging: 5g
Price: $240
Updated: 2021/12/16

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6-AMINOPHTHALIDE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

It is used to produce 6-acetylamino-phthalide. It is also used as a starting material in the reduction reaction.

Uses

6-Aminophthalide is used in the total synthesis of uncialamycin and its application to antitumor antibiotics. Also used in permethyl ningalin analogs as P-glycoprotein inhibitors.

Definition

ChEBI: 6-Amino-1,3-dihydroisobenzofuran-1-one is a member of 2-benzofurans.

Synthesis

610-93-5

57319-65-0

General procedure for the synthesis of 6-aminophthalide from 6-nitrotetrachlorophthalide: Commercially available 6-nitro-1(3H)-isobenzofuranone (9.9 g, 55 mmol) was dissolved in a solvent mixture of tetrahydrofuran (20 mL) and methanol (60 mL), and 5% palladium-carbon catalyst (1.5 g) was subsequently added. The reaction mixture was stirred at room temperature for 20 h under hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered and the solid was washed sequentially with ethyl acetate and methanol. The filtrate and washings were combined and the resulting solution was concentrated under reduced pressure. The resulting solid was washed with ethyl acetate to give 6-aminophthalide (6.21 g) as a crystalline solid. The washings were concentrated and the residue was crystallized by mixed ethyl acetate-hexane solvent to obtain additional 6-aminophthalide (0.95 g, 87% total yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, CD3OD): δ 5.225 (2H, s), 7.060 (1H, d, J = 2 Hz), 7.071 (1H, dd, J = 9, 2 Hz), 7.288 (1H, d, J = 9 Hz). Infrared spectra (KBr pressed) νmax cm-1: 3473, 3372, 3278, 1735, 1631, 1504, 1330, 1059, 992.

References

[1] Physical Chemistry Chemical Physics, 2005, vol. 7, # 24, p. 4070 - 4081
[2] Chemistry - A European Journal, 2016, vol. 22, # 13, p. 4600 - 4607
[3] ACS Catalysis, 2014, vol. 4, # 10, p. 3504 - 3511
[4] Patent: EP1362856, 2003, A1. Location in patent: Page/Page column 159
[5] Journal of Heterocyclic Chemistry, 2006, vol. 43, # 5, p. 1195 - 1204

6-AMINOPHTHALIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-AMINOPHTHALIDE Suppliers

Austria 1 Belgium 1 Canada 1 China 83 France 2 Germany 4 India 5 United Kingdom 10 United States 18 Global 125

Apollo Scientific Ltd.

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Apin Chemicals Limited (UK)

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CARBONE SCIENTIFIC CO.,LTD

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MOLEKULA Ltd.

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Atlantic Research Chemicals Ltd.

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ETA SCIENTIFIC Co.,Ltd

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UK GREEN SCIENTIFIC CO.,LIMITED

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Apin Chemicals Ltd.

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VWR International

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Butt Park Ltd.

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View Lastest Price from 6-AMINOPHTHALIDE manufacturers

R&D Scientific Inc.

Product: 6-Aminophthalide 57319-65-0
Price: US $950.00/g
Min. Order: 1g
Purity: 99 %
Supply Ability: 500 Kg
Release date: 2025-09-12

Hebei Chuanghai Biotechnology Co,.LTD

Product: 6-AMINOPHTHALIDE 57319-65-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100000kgs
Release date: 2024-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: 6-AMINOPHTHALIDE 57319-65-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

57319-65-0, 6-AMINOPHTHALIDERelated Search:

6-Nitrophthalide Fluorescein isothiocyanate FLUORESCEIN-5-MALEIMIDE Crystal violet lactone 4-Nitrophthalic anhydride 5(6)-Aminofluorescein NITROFLUORESCEIN, ISOMER 1 6-AMINOPHTHALIDE 5-AMINOPHTHALIDE,Aminophthalide,5- 4-Aminophthalide Phthalide FTHALIDE FLUORESCEIN-5-ISOTHIOCYANATE DIACETATE 5-HEXADECANOYLAMINOFLUORESCEIN FLUORESCEIN-5-THIOSEMICARBAZIDE 5(6)-(BIOTINAMIDOCAPROYLAMIDO) PENTYLTHI SAMSA-Fluorescein 6-([4,6-DICHLOROTRIAZIN-2-YL]AMINO)FLUORESCEIN HYDROCHLORIDE

BUTTPARK 33\04-93

6-AMINO-2-BENZOFURAN-1(3H)-ONE

6-AMINO-1,3-DIHYDROISOBENZOFURAN-1-ONE

6-AMINOISOBENZOFURAN-1-ONE

6-AMINOPHTHALIDE

6-Aminophtalide

6-Aminophthalide,95%

6-Amino-1,3-dihydroisobenzofuran-1-one, 95+%

6-Aminophthalide 97%

6-Aminoisobenzofuran-1(3H)-one

6-AMino-1,3-dihydroisobenzofuran-1-one hydrochloride

6-amino-1,3-dihydro-2-benzofuran-1-one

1(3H)-Isobenzofuranone, 6-amino-

6-amino-3H-2-benzofuran-1-one

RMA-283

6-Aminophthalide 6-Aminophthalide

57319-65-0

Miscellaneous

Amines

Furan&Benzofuran

Fused Ring Systems