4-Aminophthalide

Product Name: 4-Aminophthalide
CAS No.: 59434-19-4
Chemical Name: 4-Aminophthalide
Synonyms: 4-Aminophthalide;Lenalidomide Impurity 99;4-amino-3H-2-benzofuran-1-one;4-aMinoisobenzofuran-1(3H)-one;4-Amino-3H-isobenzofuran-1-one;4-Amino-2-benzofuran-1(3H)-one;1(3H)-Isobenzofuranone, 4-amino-
CBNumber: CB3971530
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 59434-19-4.mol

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4-Aminophthalide Property

Melting point:: 154-155 °C
Boiling point:: 411.0±45.0 °C(Predicted)
Density: 1.376
storage temp.: 2-8°C, protect from light
pka: 2.70±0.20(Predicted)
Appearance: Off-white to light brown Solid

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A627705
Product name: 4-Aminophthalide
Packaging: 500mg
Price: $110
Updated: 2021/12/16

TRC

Product number: A627705
Product name: 4-Aminophthalide
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA143977
Product name: 4-Aminoisobenzofuran-1(3H)-one
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA143977
Product name: 4-Aminoisobenzofuran-1(3H)-one
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA143977
Product name: 4-Aminoisobenzofuran-1(3H)-one
Packaging: 1g
Price: $250
Updated: 2021/12/16

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4-Aminophthalide Chemical Properties,Usage,Production

Uses

4-Aminophthalide acts as a reagent in the synthesis of butylphthalide derivatives with medical applications.

Synthesis

65399-18-0

59434-19-4

General procedure for the synthesis of 4-aminoisobenzofuran-1(3H)-one from 4-nitroisobenzofuran-1(3H)-one: 4-nitroisobenzofuran-1(3H)-one (1.0 g, 5.58 mmol) and 10% Pd/C (0.1 g) were suspended in ethyl acetate (30 mL). The reaction system was purged with hydrogen (1 atm) and stirred for 3 hours at 25°C. After completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was concentrated to afford 4-aminoisobenzofuran-1(3H)-one (0.8 g, 96% yield) as an off-white solid. Mass spectrum (ESI) m/z: 150 (M + 1)+. 1H-NMR (400 MHz, CDCl3) δ 3.82 (s, broad peak, 1H), 5.19 (s, 3H), 6.91-6.95 (m, 1H), 7.32-7.36 (m, 2H).

References

[1] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 48
[2] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 84-85
[3] Journal fuer Praktische Chemie/Chemiker-Zeitung, 1993, vol. 335, # 1, p. 17 - 22
[4] Advanced Synthesis and Catalysis, 2010, vol. 352, # 11-12, p. 1834 - 1840
[5] Chemistry - A European Journal, 2011, vol. 17, # 21, p. 5903 - 5907

4-Aminophthalide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Aminophthalide Suppliers

Canada 1 China 71 India 1 Slovakia 1 United Kingdom 1 United States 6 Global 81

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View Lastest Price from 4-Aminophthalide manufacturers

Career Henan Chemical Co

Product: 4-Aminophthalide 59434-19-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

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4-Amino-2-benzofuran-1(3H)-one

4-Amino-3H-isobenzofuran-1-one

4-Aminophthalide

4-aMinoisobenzofuran-1(3H)-one

1(3H)-Isobenzofuranone, 4-amino-

Lenalidomide Impurity 99

4-amino-3H-2-benzofuran-1-one

59434-19-4

Heterocycles

Heterocyclic Compound