ChemicalBook > CAS DataBase List > 4-Aminophthalide

4-Aminophthalide

Product Name: 4-Aminophthalide
CAS No.: 59434-19-4
Chemical Name: 4-Aminophthalide
Synonyms: 4-Aminophthalide;Lenalidomide Impurity 99;4-amino-3H-2-benzofuran-1-one;4-aMinoisobenzofuran-1(3H)-one;4-Amino-3H-isobenzofuran-1-one;4-Amino-2-benzofuran-1(3H)-one;1(3H)-Isobenzofuranone, 4-amino-
CBNumber: CB3971530
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 59434-19-4.mol

Less

4-Aminophthalide Property

Melting point:: 154-155 °C
Boiling point:: 411.0±45.0 °C(Predicted)
Density: 1.376
storage temp.: 2-8°C, protect from light
pka: 2.70±0.20(Predicted)
Appearance: Off-white to light brown Solid

Less

Safety

HS Code: 2932990090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: A627705
Product name: 4-Aminophthalide
Packaging: 500mg
Price: $110
Updated: 2021/12/16

TRC

Product number: A627705
Product name: 4-Aminophthalide
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA143977
Product name: 4-Aminoisobenzofuran-1(3H)-one
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA143977
Product name: 4-Aminoisobenzofuran-1(3H)-one
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA143977
Product name: 4-Aminoisobenzofuran-1(3H)-one
Packaging: 1g
Price: $250
Updated: 2021/12/16

Less

4-Aminophthalide Chemical Properties,Usage,Production

Uses

4-Aminophthalide acts as a reagent in the synthesis of butylphthalide derivatives with medical applications.

Synthesis

65399-18-0

59434-19-4

General procedure for the synthesis of 4-aminoisobenzofuran-1(3H)-one from 4-nitroisobenzofuran-1(3H)-one: 4-nitroisobenzofuran-1(3H)-one (1.0 g, 5.58 mmol) and 10% Pd/C (0.1 g) were suspended in ethyl acetate (30 mL). The reaction system was purged with hydrogen (1 atm) and stirred for 3 hours at 25°C. After completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was concentrated to afford 4-aminoisobenzofuran-1(3H)-one (0.8 g, 96% yield) as an off-white solid. Mass spectrum (ESI) m/z: 150 (M + 1)+. 1H-NMR (400 MHz, CDCl3) δ 3.82 (s, broad peak, 1H), 5.19 (s, 3H), 6.91-6.95 (m, 1H), 7.32-7.36 (m, 2H).

References

[1] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 48
[2] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 84-85
[3] Journal fuer Praktische Chemie/Chemiker-Zeitung, 1993, vol. 335, # 1, p. 17 - 22
[4] Advanced Synthesis and Catalysis, 2010, vol. 352, # 11-12, p. 1834 - 1840
[5] Chemistry - A European Journal, 2011, vol. 17, # 21, p. 5903 - 5907

4-Aminophthalide Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-Aminophthalide Suppliers

Canada 1 China 71 India 1 Slovakia 1 United Kingdom 1 United States 6 Global 81

Wuhan ariel chemical Co., LTD.

Tel: 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3764
Advantage: 58

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2151
Advantage: 55

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3731
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Beijing Wuyunyongchang Science and Technology Co., Ltd.

Tel: 15210642910
Email: moon5.1days@126.com
Country: China
ProdList: 202
Advantage: 56

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Shanghai PharmaPartner Co., Ltd.

Tel: 19983777532
Fax: -
Email: pharmabridge@163.com
Country: China
ProdList: 501
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Nanjing BAM Biomedical Technology Co., Ltd.

Tel: 18066080842 13952020641
Fax: 025-58912720
Email: bamd@foxmail.com
Country: China
ProdList: 759
Advantage: 55

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9624
Advantage: 60

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

Nanjing Chengqian Pharmaceutical Technology Co., Ltd.

Tel: 025-52791040 18652036685
Email: haozhongwen@126.com
Country: China
ProdList: 767
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

ROSEWA HOLDING GROUP CO.,LIMITED

Tel: +86-023-62871537
Email: sales@rosewachem.com
Country: China
ProdList: 2803
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8615838112936
Email: alfa10@alfachem.cn
Country: China
ProdList: 12921
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Amel Pharmatech Corporation

Tel: 027-888-4366503
Fax: 888-502-1736
Email: sales@amelpharmatech.com
Country: China
ProdList: 5000
Advantage: 58

Changzhou Yinghao Technology Development Co., Ltd

Tel: 15151934985
Email: sales@yingsapharm.com
Country: China
ProdList: 5181
Advantage: 58

Shenyang Maud Pharmaceutical Technology Co., Ltd.

Tel: 024-23982345
Email: 1020788318@qq.com
Country: China
ProdList: 2251
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26028
Advantage: 58

Zhende Chemical Technology (Shanghai) Co., Ltd.

Tel: 15601952568
Fax: 3004479441
Email: sales4@myuchem.com
Country: China
ProdList: 2989
Advantage: 58

Zhengzhou Convergence Chemical Co. LTD

Tel: 0371-0371-53736046 13393710386
Fax: QQ:2853979814
Email: 2853979814@qq.com
Country: China
ProdList: 9947
Advantage: 58

Jiangxi Boye Medical Technology Co., Ltd

Tel: 027-18971341812/18971341812 18971341812
Fax: 027-81625225
Email: anikay@boyechemicals.com
Country: China
ProdList: 506
Advantage: 58

Zhengzhou Akem Chemical Co., Ltd

Tel: 13303867194
Email: 3001317055@qq.com
Country: China
ProdList: 9681
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Henan yingchuang

Tel: 16650708709
Fax: qq:778660296
Email: hnyingchuang@163.com
Country: China
ProdList: 3965
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Qingzhou dafeng import and export Co. LTD

Tel: 16773308882
Email: 927608786@qq.com
Country: China
ProdList: 3051
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18921922613
Email: hywu@aikonchem.com
Country: China
ProdList: 10709
Advantage: 58

Changzhou Wanyao Biotechnology Co., Ltd.

Tel: 051989185693 15312551983
Email: 2410037592@qq.com
Country: China
ProdList: 1201
Advantage: 58

Heze Aiding Pharmaceutical Co., Ltd

Tel: 17661365138
Email: 2845578351@qq.com
Country: China
ProdList: 7115
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50751
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Tengjun Biotechnology Co. LTD

Tel: 19821570922
Email: angela@labgogo.com
Country: China
ProdList: 9896
Advantage: 58

Less

View Lastest Price from 4-Aminophthalide manufacturers

Career Henan Chemical Co

Product: 4-Aminophthalide 59434-19-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

59434-19-4, 4-AminophthalideRelated Search:

Benzofuran 3-Aminophenol 4-Aminobenzoic acid 2-Aminobenzaldehyde 6-Aminocaproic acid 4-Dimethylaminobenzoic acid Sulfanilamide p-Anisidine Sulfanilic acid Aniline ALTRENOGEST 3-Aminoacetophenone Glycine Furazolidone Methyl anthranilate Tris(hydroxymethyl)aminomethane Anthranilic acid 4-Nitrophthalide

4-Amino-2-benzofuran-1(3H)-one

4-Amino-3H-isobenzofuran-1-one

4-Aminophthalide

4-aMinoisobenzofuran-1(3H)-one

1(3H)-Isobenzofuranone, 4-amino-

Lenalidomide Impurity 99

4-amino-3H-2-benzofuran-1-one

59434-19-4

Heterocycles

Heterocyclic Compound