4-Aminophthalide
- Product Name
- 4-Aminophthalide
- CAS No.
- 59434-19-4
- Chemical Name
- 4-Aminophthalide
- Synonyms
- 4-Aminophthalide;Lenalidomide Impurity 99;4-amino-3H-2-benzofuran-1-one;4-aMinoisobenzofuran-1(3H)-one;4-Amino-3H-isobenzofuran-1-one;4-Amino-2-benzofuran-1(3H)-one;1(3H)-Isobenzofuranone, 4-amino-
- CBNumber
- CB3971530
- Molecular Formula
- C8H7NO2
- Formula Weight
- 149.15
- MOL File
- 59434-19-4.mol
4-Aminophthalide Property
- Melting point:
- 154-155 °C
- Boiling point:
- 411.0±45.0 °C(Predicted)
- Density
- 1.376
- storage temp.
- 2-8°C, protect from light
- pka
- 2.70±0.20(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A627705
- Product name
- 4-Aminophthalide
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- A627705
- Product name
- 4-Aminophthalide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA143977
- Product name
- 4-Aminoisobenzofuran-1(3H)-one
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FA143977
- Product name
- 4-Aminoisobenzofuran-1(3H)-one
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FA143977
- Product name
- 4-Aminoisobenzofuran-1(3H)-one
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
4-Aminophthalide Chemical Properties,Usage,Production
Uses
4-Aminophthalide acts as a reagent in the synthesis of butylphthalide derivatives with medical applications.
Synthesis
65399-18-0
59434-19-4
General procedure for the synthesis of 4-aminoisobenzofuran-1(3H)-one from 4-nitroisobenzofuran-1(3H)-one: 4-nitroisobenzofuran-1(3H)-one (1.0 g, 5.58 mmol) and 10% Pd/C (0.1 g) were suspended in ethyl acetate (30 mL). The reaction system was purged with hydrogen (1 atm) and stirred for 3 hours at 25°C. After completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was concentrated to afford 4-aminoisobenzofuran-1(3H)-one (0.8 g, 96% yield) as an off-white solid. Mass spectrum (ESI) m/z: 150 (M + 1)+. 1H-NMR (400 MHz, CDCl3) δ 3.82 (s, broad peak, 1H), 5.19 (s, 3H), 6.91-6.95 (m, 1H), 7.32-7.36 (m, 2H).
References
[1] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 48
[2] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 84-85
[3] Journal fuer Praktische Chemie/Chemiker-Zeitung, 1993, vol. 335, # 1, p. 17 - 22
[4] Advanced Synthesis and Catalysis, 2010, vol. 352, # 11-12, p. 1834 - 1840
[5] Chemistry - A European Journal, 2011, vol. 17, # 21, p. 5903 - 5907
4-Aminophthalide Preparation Products And Raw materials
Raw materials
Preparation Products
4-Aminophthalide Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 4-Aminophthalide manufacturers
- Product
- 4-Aminophthalide 59434-19-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-09