Figitumumab

Product Name: Figitumumab
CAS No.: 943453-46-1
Chemical Name: Figitumumab
Synonyms: Figitumumab;Figitumumab (anti-IGF1R);Research Grade Figitumumab;Research Grade Figitumumab(DHC29905)
CBNumber: CB38080797
Formula Weight: 0
MOL File: Mol file

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Figitumumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Figitumumab Chemical Properties,Usage,Production

Uses

Figitumumab (CP-751871) is a potent and fully human monoclonal anti–insulin-like growth factor 1 receptor (IGF1R) antibody. Figitumumab prevents IGF1 from binding to IGF1R with an IC50 of 1.8 nM[1].

in vivo

Figitumumab (CP-751871) (31-125 μg/mouse; i.p.; once) induces the down-regulation of tumor associated IGF-1R in mice^[2].
Figitumumab (62.5-500 μg/mouse; i.p.; once) inhibits the growth of s.c. xenografts derived from colon (Colo-205), breast (MCF7), and lung (H460) cancer cell lines in mice^[2].

Animal Model:	Female athymic mice (CD-1 nu/nu) bearing NIH3T3/IGF-1R tumors^[2]
Dosage:	31 to 125 μg per mouse
Administration:	Intraperitoneal injection, once
Result:	Resulted in a serum C_max between 12 and 24 hours. At 24 hours, there was a dose-dependent reduction of IGF-1R protein in tumors, with 50% reduction observed at a serum concentration of 15 μg/mL. Resulted in a down-regulation of IGF-1R from the tumor. The half-life in an athymic mouse was determined to be 4 to 6 days by longer-term studies.

Animal Model:	Female athymic mice (CD-1 nu/nu), human Colo-205 tumor xenograft model^[2]
Dosage:	62.5 μg or 250 μg per mouse
Administration:	Intraperitoneal injection, once
Result:	Inhibited the tumor growth.

References

[1] Pavlicek A, et al. Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871). Mol Cancer Ther. 2013 Dec;12(12):2929-39. DOI:10.1158/1535-7163.MCT-13-0442-T
[2] Cohen BD, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res. 2005 Mar 1;11(5):2063-73. DOI:10.1158/1078-0432.CCR-04-1070

Figitumumab Preparation Products And Raw materials

Raw materials

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Figitumumab Suppliers

China 18 United States 1 Global 19

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Figitumumab

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Figitumumab (anti-IGF1R)

Research Grade Figitumumab

943453-46-1