ChemicalBook > CAS DataBase List > Iodoacetic acid
Iodoacetic acid
- Product Name
- Iodoacetic acid
- CAS No.
- 64-69-7
- Chemical Name
- Iodoacetic acid
- Synonyms
- IA;iodoacetate;monoiodoacetate;iodoacetic;lodoacetic acid;MONOIODOACETIC ACID;SKL245;CH2ICOOH;iodo-aceticaci;IODOACETIC ACID
- CBNumber
- CB3854071
- Molecular Formula
- C2H3IO2
- Formula Weight
- 185.95
- MOL File
- 64-69-7.mol
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Iodoacetic acid Property
- Melting point:
- 79 °C
- Boiling point:
- 208°C
- Density
- 2.2003 (estimate)
- Flash point:
- 208°C
- storage temp.
- 2-8°C
- solubility
- H2O: soluble, clear to hazy
- form
- Liquid
- pka
- 3.12(at 25℃)
- color
- faintly yellow
- Water Solubility
- 600 g/L (20 ºC)
- Sensitive
- Light Sensitive
- Merck
- 14,5025
- BRN
- 1739079
- Stability:
- Stable. Incompatible with strong oxidizing agents, bases, strong reducing agents. Store at -20 C.
- CAS DataBase Reference
- 64-69-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetic acid, iodo-(64-69-7)
- EPA Substance Registry System
- Iodoacetic acid (64-69-7)
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Safety
- Hazard Codes
- T,C
- Risk Statements
- 25-35
- Safety Statements
- 22-36/37/39-45
- RIDADR
- UN 2923 8/PG 1
- WGK Germany
- 1
- RTECS
- AI3500000
- F
- 8-9
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29159080
- Hazardous Substances Data
- 64-69-7(Hazardous Substances Data)
- Toxicity
- LD50 intravenous in dog: 45mg/kg
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- I4386
- Product name
- Iodoacetic acid
- Purity
- ≥98.0% (T)
- Packaging
- 10g
- Price
- $55.6
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- I4386
- Product name
- Iodoacetic acid
- Purity
- ≥98.0% (T)
- Packaging
- 25g
- Price
- $102
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A12410
- Product name
- Iodoacetic acid, 97+%
- Packaging
- 25g
- Price
- $90.9
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A12410
- Product name
- Iodoacetic acid, 97+%
- Packaging
- 100g
- Price
- $255
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- I4386
- Product name
- Iodoacetic acid
- Purity
- ≥98.0% (T)
- Packaging
- 100g
- Price
- $312
- Updated
- 2024/03/01
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Iodoacetic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystalline powder
Uses
Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.
Uses
Iodoacetic acid is used as a reagent for the modification of sulfhydryl groups in organic synthesis. It reacts with cysteine moiety in proteins to prevent the re-formation of disulfide bonds during protein sequencing. It is also used as a general reagent in acylation reactions as well as in glycopeptide synthesis.
Definition
ChEBI: A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
General Description
Colorless or white crystals.
Air & Water Reactions
May be sensitive to heat, light, and air. Water soluble
Reactivity Profile
Iodoacetic acid reacts vigorously with bases and is corrosive.
Fire Hazard
Flash point data for Iodoacetic acid are not available, but Iodoacetic acid is probably non-flammable.
Biochem/physiol Actions
Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.
Purification Methods
Crystallise it from pet ether (b 60-80o) or CHCl3/CCl4. [Beilstein 2 IV 534.]
Iodoacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Iodoacetic acid manufacturers
Hebei Mojin Biotechnology Co., Ltd
- Product
- Iodoacetic acid 64-69-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-01
Hebei Mojin Biotechnology Co., Ltd
- Product
- Omeprazole 64-69-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-01
Hebei Guanlang Biotechnology Co., Ltd.
- Product
- Omeprazole 64-69-7
- Price
- US $1.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-05-07
64-69-7, Iodoacetic acidRelated Search:
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TRIIODOACETIC ACID
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diiodoacetic acid
chloroiodoacetic acid
Iodoacetic acid chloride
Iodine
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IODOACETIC ACID (2-13C)