Iodoacetic acid

Product Name: Iodoacetic acid
CAS No.: 64-69-7
Chemical Name: Iodoacetic acid
Synonyms: IA;iodoacetate;monoiodoacetate;iodoacetic;lodoacetic acid;MONOIODOACETIC ACID;SKL245;CH2ICOOH;iodo-aceticaci;IODOACETIC ACID
CBNumber: CB3854071
Molecular Formula: C2H3IO2
Formula Weight: 185.95
MOL File: 64-69-7.mol

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Iodoacetic acid Property

Melting point:: 79 °C
Boiling point:: 208°C
Density: 2.2003 (estimate)
Flash point:: 208°C
storage temp.: 2-8°C
solubility: H2O: soluble, clear to hazy
form: Liquid
pka: 3.12(at 25℃)
color: faintly yellow
Water Solubility: 600 g/L (20 ºC)
Sensitive: Light Sensitive
Merck: 14,5025
BRN: 1739079
Stability:: Stable. Incompatible with strong oxidizing agents, bases, strong reducing agents. Store at -20 C.
CAS DataBase Reference: 64-69-7(CAS DataBase Reference)
NIST Chemistry Reference: Acetic acid, iodo-(64-69-7)
EPA Substance Registry System: Iodoacetic acid (64-69-7)

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Safety

Hazard Codes: T,C
Risk Statements: 25-35
Safety Statements: 22-36/37/39-45
RIDADR: UN 2923 8/PG 1
WGK Germany: 1
RTECS: AI3500000
F: 8-9
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29159080
Hazardous Substances Data: 64-69-7(Hazardous Substances Data)
Toxicity: LD50 intravenous in dog: 45mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I4386
Product name: Iodoacetic acid
Purity: ≥98.0% (T)
Packaging: 10g
Price: $55.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: I4386
Product name: Iodoacetic acid
Purity: ≥98.0% (T)
Packaging: 25g
Price: $102
Updated: 2024/03/01

Alfa Aesar

Product number: A12410
Product name: Iodoacetic acid, 97+%
Packaging: 25g
Price: $90.9
Updated: 2024/03/01

Alfa Aesar

Product number: A12410
Product name: Iodoacetic acid, 97+%
Packaging: 100g
Price: $255
Updated: 2024/03/01

Sigma-Aldrich

Product number: I4386
Product name: Iodoacetic acid
Purity: ≥98.0% (T)
Packaging: 100g
Price: $312
Updated: 2024/03/01

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Iodoacetic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.

Uses

Iodoacetic acid is used as a reagent for the modification of sulfhydryl groups in organic synthesis. It reacts with cysteine moiety in proteins to prevent the re-formation of disulfide bonds during protein sequencing. It is also used as a general reagent in acylation reactions as well as in glycopeptide synthesis.

Definition

ChEBI: A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.

General Description

Colorless or white crystals.

Air & Water Reactions

May be sensitive to heat, light, and air. Water soluble

Reactivity Profile

Iodoacetic acid reacts vigorously with bases and is corrosive.

Fire Hazard

Flash point data for Iodoacetic acid are not available, but Iodoacetic acid is probably non-flammable.

Biochem/physiol Actions

Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.

Purification Methods

Crystallise it from pet ether (b 60-80o) or CHCl3/CCl4. [Beilstein 2 IV 534.]

Iodoacetic acid Preparation Products And Raw materials

Raw materials

Chloroacetic acid Copper (II) acetate monohydrate Iodine Acetic acid

Preparation Products

Lornoxicam

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Iodoacetic acid Suppliers

Belgium 1 Canada 1 China 103 Europe 2 Germany 5 India 9 Japan 3 Russia 1 Slovakia 1 Switzerland 2 United Kingdom 9 United States 32 Global 169

Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376090521
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 970
Advantage: 60

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Syntechem Co.,Ltd

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Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

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View Lastest Price from Iodoacetic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Iodoacetic acid 64-69-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Qingdao RENAS Polymer Material Co., Ltd.

Product: Iodoacetic acid 64-69-7
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-09-24

Hebei Mojin Biotechnology Co., Ltd

Product: Iodoacetic acid 64-69-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-01

64-69-7, Iodoacetic acidRelated Search:

Hyaluronic acid Folic acid Citric acid Ethyl 2-(Chlorosulfonyl)acetate Stearic acid IODOACETIC ACID SODIUM SALT,IODOACETIC ACID SODIUM APPROX. 99% 2-iodopropionic acid IODOACETIC ACID ETHYL ESTER,Iodoacetic acid ethyl,2-Iodoacetic acid ethyl ester Ethyl iododifluoroacetate Iodoacetic acid 4-nitrophenyl ester TRIIODOACETIC ACID Bis(iodoacetic acid)anhydride,Iodoacetic acid anhydride diiodoacetic acid chloroiodoacetic acid Iodoacetic acid chloride Iodine ETHYL 2-IODOPROPIONATE IODOACETIC ACID (2-13C)

iodoacetic

iodo-aceticaci

Kyselina jodoctova

kyselinajodoctova

monoiodoacetate

RARECHEM AL BO 0101

MONOIODOACETIC ACID

VITAS-BB TBB000669

Aceticacid,iodo-

CH2ICOOH

IA

iodoacetate

IODOACETIC ACID MONO

IODOACETIC ACID

IODOACETIC ACID FREE ACID APPROX 99%,*YE LLOW POWDER

IODOACETIC ACID APPROX. 99% WHITE TO OFF

IODOACETIC ACID R. G.

IodoaceticAcid>99%

IodoaceticAcid97%

IODOACETICACID,REAGENT

Iodoethanoic acid

Iodoacetic acid, 97% 25GR

Iodoacetic acid, >=99.5%

Iodiacetic acid

IODOACETIC ACID, >= 98.0 % (T)

Acetic acid, 2-iodo-

lodoacetic acid

SKL245

Iodoacetic acid, GR 99%

64-69-7

ICH2COOH

ICH2CO2H

C2H3IO2

Synthetic Reagents

Organic Building Blocks

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Puriss p.a.

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Analytical Reagents

Analytical Chromatography Product Catalog

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Reagents for cysteine modification

Specific Amino Acid Modification

Protein Modification

Analytical Reagents for General Use

I-N, Puriss p.a.

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