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Iodoacetic acid

Product Name
Iodoacetic acid
CAS No.
64-69-7
Chemical Name
Iodoacetic acid
Synonyms
IA;iodoacetate;monoiodoacetate;iodoacetic;lodoacetic acid;MONOIODOACETIC ACID;SKL245;CH2ICOOH;iodo-aceticaci;IODOACETIC ACID
CBNumber
CB3854071
Molecular Formula
C2H3IO2
Formula Weight
185.95
MOL File
64-69-7.mol
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Iodoacetic acid Property

Melting point:
79 °C
Boiling point:
208°C
Density 
2.2003 (estimate)
Flash point:
208°C
storage temp. 
2-8°C
solubility 
H2O: soluble, clear to hazy
form 
Liquid
pka
3.12(at 25℃)
color 
faintly yellow
Water Solubility 
600 g/L (20 ºC)
Sensitive 
Light Sensitive
Merck 
14,5025
BRN 
1739079
Stability:
Stable. Incompatible with strong oxidizing agents, bases, strong reducing agents. Store at -20 C.
CAS DataBase Reference
64-69-7(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, iodo-(64-69-7)
EPA Substance Registry System
Iodoacetic acid (64-69-7)
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Safety

Hazard Codes 
T,C
Risk Statements 
25-35
Safety Statements 
22-36/37/39-45
RIDADR 
UN 2923 8/PG 1
WGK Germany 
1
RTECS 
AI3500000
8-9
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29159080
Hazardous Substances Data
64-69-7(Hazardous Substances Data)
Toxicity
LD50 intravenous in dog: 45mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I4386
Product name
Iodoacetic acid
Purity
≥98.0% (T)
Packaging
10g
Price
$55.6
Updated
2024/03/01
Sigma-Aldrich
Product number
I4386
Product name
Iodoacetic acid
Purity
≥98.0% (T)
Packaging
25g
Price
$102
Updated
2024/03/01
Alfa Aesar
Product number
A12410
Product name
Iodoacetic acid, 97+%
Packaging
25g
Price
$90.9
Updated
2024/03/01
Alfa Aesar
Product number
A12410
Product name
Iodoacetic acid, 97+%
Packaging
100g
Price
$255
Updated
2024/03/01
Sigma-Aldrich
Product number
I4386
Product name
Iodoacetic acid
Purity
≥98.0% (T)
Packaging
100g
Price
$312
Updated
2024/03/01
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Iodoacetic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.

Uses

Iodoacetic acid is used as a reagent for the modification of sulfhydryl groups in organic synthesis. It reacts with cysteine moiety in proteins to prevent the re-formation of disulfide bonds during protein sequencing. It is also used as a general reagent in acylation reactions as well as in glycopeptide synthesis.

Definition

ChEBI: A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.

General Description

Colorless or white crystals.

Air & Water Reactions

May be sensitive to heat, light, and air. Water soluble

Reactivity Profile

Iodoacetic acid reacts vigorously with bases and is corrosive.

Fire Hazard

Flash point data for Iodoacetic acid are not available, but Iodoacetic acid is probably non-flammable.

Biochem/physiol Actions

Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.

Purification Methods

Crystallise it from pet ether (b 60-80o) or CHCl3/CCl4. [Beilstein 2 IV 534.]

Iodoacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Iodoacetic acid manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Iodoacetic acid 64-69-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-01
Hebei Mojin Biotechnology Co., Ltd
Product
Omeprazole 64-69-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-01
Hebei Guanlang Biotechnology Co., Ltd.
Product
Omeprazole 64-69-7
Price
US $1.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-05-07

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