ChemicalBook > CAS DataBase List > S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

Product Name
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
CAS No.
132335-47-8
Chemical Name
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
Synonyms
Duloxetine Impurity 52;Duloxetine intermediate;Duloxetine N-Methyl Oxalate;N-Methyl Duloxetine Oxalate;Duloxetine N-methyl Impurity;Duloxetine Impurity 8 Oxalate;S-(+)-N,N-Dimethyl-3-(1-naphtho;Duloxetine Impurity 8(Oxalicacid);N-Methyl Duloxetine Oxalate;Duloxetine N-Methyl (S)-Isomer Oxalate
CBNumber
CB3855078
Molecular Formula
C21H23NO5S
Formula Weight
401.48
MOL File
132335-47-8.mol
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S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Property

Melting point:
>145°C (dec.)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1/C19H21NOS.C2H2O4/c1-20(2)13-12-18(19-11-6-14-22-19)21-17-10-5-8-15-7-3-4-9-16(15)17;3-1(4)2(5)6/h3-11,14,18H,12-13H2,1-2H3;(H,3,4)(H,5,6)/t18-;/s3
InChIKey
GYUDMXKAVMKVPS-QAYAHANANA-N
SMILES
N(C)(C)CC[C@H](OC1=C2C(C=CC=C2)=CC=C1)C1SC=CC=1.C(O)(=O)C(O)=O |&1:5,r|
CAS DataBase Reference
132335-47-8(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

H302Harmful if swallowed

H313May be harmful in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC
Product number
M303880
Product name
N-MethylDuloxetineOxalate
Packaging
10g
Price
$150
Updated
2021/12/16
TRC
Product number
M303880
Product name
N-MethylDuloxetineOxalate
Packaging
25g
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD40487
Product name
S-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-1-propanamine oxalate
Packaging
100mg
Price
$56
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD40487
Product name
S-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-1-propanamine oxalate
Packaging
250mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD40487
Product name
S-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-1-propanamine oxalate
Packaging
500mg
Price
$140
Updated
2021/12/16
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S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A duloxetine impurity.

Synthesis

321-38-0

144-62-7

132335-49-0

132335-47-8

General procedure for the synthesis of (S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate from 1-fluoronaphthalene, oxalic acid and R-3-(dimethylamino)-1-(2-thiophenyl)-1-propanol: R-3-(dimethylamino)-1-(2-thiophenyl)-1-propanol (2.0 g, 0.011 mol) was was dissolved in dimethylacetamide (100 mL) and a suspension of 60% sodium hydride (463 mg, 0.012 mol) was added slowly and dropwise. The reaction mixture was heated at 70°C with stirring for 20 minutes. Subsequently, 1-fluoronaphthalene (1.27 mL, 0.012 mol) was added dropwise to the reaction system and heating was continued with stirring at 110 °C for 60 min. After completion of the reaction, the reaction mixture was diluted with water and extracted twice with ether. The organic phases were combined, washed sequentially with water and saturated sodium chloride solution, and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the oily product (S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine (3.28 g, 75.6% yield).

References

[1] Patent: JP2016/172704, 2016, A. Location in patent: Paragraph 0027; 0053

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Preparation Products And Raw materials

Raw materials

Preparation Products

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S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Suppliers

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View Lastest Price from S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate manufacturers

Chemwill Asia Co.,Ltd.
Product
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate in stock Factory 132335-47-8
Price
US $1.00/KG
Min. Order
1KG
Purity
TOP 3 Factory in China
Supply Ability
Top 3 largest production capacity Factory
Release date
2019-04-03
Career Henan Chemical Co
Product
S-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate(S)- 132335-47-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-26

132335-47-8, S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalateRelated Search:

Dimethyl sulfoxide Dimethyldimethoxysilane Basic Green 4 Sodium oxalate Cephalothin sodium Tetrahydrothiophene Isopropylamine Dimethyl disulfide Diethyl oxalate Dimethyl fumarate Dimethyl carbonate LITHIUM OXALATE Diethoxydimethylsilane ETHANE Dimethyl sulfate Dimethyl ether Dacthal N,N-Dimethylformamide

  • S-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate(S)-
  • Duloxetine N-Methyl Oxalate
  • (S)-(+)-N,N-diMethyl-3-(naphthloxy)-3-(2-thienyl)
  • (S)-(+)-N,N-Dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thinyl)Propanamine Oxalate
  • (S)-(+)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)-propanamine oxalate
  • (S)-(+)-N,N-DIMETHYL-3-NAPTHTOXY-(2-THIOPHENE) PROPYLAMINE OXALATE
  • Duloxetine intermediate
  • S-(+)-N1N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)-1-PROPANAMINE OXALATE
  • (S)-(+)-N,N-dimethyl-3-(1-naphthloxy)-3-(2-thienyl)prpylamine oxalate
  • S(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamineoxalate
  • (S)-(+)-N,N-DIMETHYL-3-(1-NAPTHTALENYLOXY)-3-(2-THIENYL)-1-PROPANAMINEHYDROCHLORIDE
  • S-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)-1-PROPANEMAINEOXALATE
  • (S)-(+)-N,N-DIMETHYL-3-NAPHTHOXY-(2-THIENYL)-PROPANAMINE OXALATE, DULOXETIN INTERMEDIATE
  • S-(+)-N,N-Dimethyl-3-(1-phthoxy)-3-(2-thienyl)-1-propylamine oxalate
  • s-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-1-propanamine oxalate
  • (S)-N,N-Dimethyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine ethanedioate (1:1)
  • S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
  • 2-Thiophenepropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-, eth
  • (S)-(+)-N,N-DIMETHYL-3-NAPHTHOXY-(2-THIOPHENE)-PROPYLAMINE OXALATE
  • S-(+)-N,N-Dimethyl-3-(1-naphtho
  • (S)-N,N-DiMethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanaMine Ethanedioate
  • N-Methyl Duloxetine Oxalate
  • (S)-N,N-DiMethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aMine oxalate
  • S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate in stock Factory
  • N,N-dimethyl-3-(1-naphthalenyloxy)-3-thiophen-2-yl-1-propanamine
  • Duloxetine Impurity 8 Oxalate
  • Duloxetine N-Methyl (S)-Isomer Oxalate
  • (S)-(+) N,N-dimethyl-3-(1-napthalenyloxy)-3-(2_thieyl)prapanamine oxalate
  • Duloxetine N-methyl Impurity
  • Duloxetine Impurity 52
  • S-(+)-N,N-dimethtl-3-(1-naphthoxy)-3-(2-thienyl)-1-propanamine oxalate
  • 2-Thiophenepropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-, ethanedioate (1:1), (γS)-
  • (3S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Oxalate (N-Methylduloxetine Oxalate)
  • Duloxetine Impurity 8(Oxalicacid)
  • (3S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine ethanedioate
  • (3S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Oxalate (N-Methylduloxetine
  • <i>N</i>-Methyl Duloxetine Oxalate
  • 132335-47-8
  • C19H21NOSC2H2O4
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds