(S)-4-(Phenylmethyl)-2-piperazineethanol
- Product Name
- (S)-4-(Phenylmethyl)-2-piperazineethanol
- CAS No.
- 477220-33-0
- Chemical Name
- (S)-4-(Phenylmethyl)-2-piperazineethanol
- Synonyms
- (S)-2-(4-benzylpiperazin-2-yl)ethanol;2-((S)-4-benzylpiperazin-2-yl)ethanol;(s)-4-(phenylmethyl)-2-piperazineethanol;(S)-2-(4-Benzylpiperazin-2-yl)ethan-1-ol;2-[(2S)-4-benzylpiperazin-2-yl]ethan-1-ol;(S)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl;2-Piperazineethanol, 4-(phenylmethyl)-, (2S)-
- CBNumber
- CB3855104
- Molecular Formula
- C13H20N2O
- Formula Weight
- 220.31
- MOL File
- 477220-33-0.mol
(S)-4-(Phenylmethyl)-2-piperazineethanol Property
- storage temp.
- Store at Room Tem.
- Appearance
- light yellow powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CCH0000498
- Product name
- 2-((S)-4-BENZYLPIPERAZIN-2-YL)ETHANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1575
- Updated
- 2021/12/16
- Product number
- CCH0000498
- Product name
- 2-((S)-4-BENZYLPIPERAZIN-2-YL)ETHANOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2708.48
- Updated
- 2021/12/16
(S)-4-(Phenylmethyl)-2-piperazineethanol Chemical Properties,Usage,Production
Synthesis
612506-99-7
477220-33-0
General procedure for the synthesis of 2-[(S)-4-benzyl-2-yl]ethanol from the compound (CAS:612506-99-7): to a tetrahydrofuran (1L) solution of methyl S-(4-benzyl-3,6-dioxopiperazin-2-yl)acetate (31.9 g, 0.12 mol) at 0 °C, lithium aluminum hydride (350 mL, 1.0 M tetrahydrofuran solution). The reaction mixture was stirred overnight at room temperature. Subsequently, the reaction was quenched by successive careful addition of 13.3 mL of water, 13.3 mL of 15% aqueous sodium hydroxide solution and 39.9 mL of water, during which vigorous stirring was maintained to ensure the formation of a fine precipitate. The reaction mixture was filtered through a sintered funnel and the solid fraction was washed well with tetrahydrofuran and dichloromethane. The filtrate was concentrated under vacuum to give 26.5 g of an oily residue which was directly sampled on a silica gel column. Column chromatographic separation was carried out using a 5% 7N ammonia-methanol dichloromethane mixture as eluent to obtain the target product, which was an orange-colored oil and solidified to a solid after vacuum drying. This solid was dissolved in acetonitrile, sonicated for several minutes and filtered to give 7.5 g (25% yield) of S-(-)-2-(4-benzylpiperazin-2-yl)ethanol as an off-white crystalline solid with a melting point of 78.9-80 °C. The mother liquor was concentrated to give 6.8 g (23% yield) of a slightly less pure product as an amorphous solid.
References
[1] Patent: WO2003/82877, 2003, A1. Location in patent: Page/Page column 96-97
[2] Patent: WO2005/26177, 2005, A1. Location in patent: Page/Page column 91-92
[3] Patent: WO2004/14895, 2004, A1. Location in patent: Page 125-126
(S)-4-(Phenylmethyl)-2-piperazineethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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