ChemicalBook > CAS DataBase List > 1-Actamido-3,5-dimethyladmantane

1-Actamido-3,5-dimethyladmantane

Product Name
1-Actamido-3,5-dimethyladmantane
CAS No.
19982-07-1
Chemical Name
1-Actamido-3,5-dimethyladmantane
Synonyms
Acetyl memantine;Memantine N-Acetyl;N-Acetyl Memantine ;MeMantine IMpurity C;Memantine impurity E;Memantine Acetyl Impurity;Memantine Related Compound F;Memantine Impurity C (N-Acetyl;1-actamido-3,5-dimethyladmantane;1-ACETAMIDO-3,5-DIMETHYLADMANTANE
CBNumber
CB3855230
Molecular Formula
C14H23NO
Formula Weight
221.34
MOL File
19982-07-1.mol
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1-Actamido-3,5-dimethyladmantane Property

Melting point:
110-111°C
Boiling point:
348.5±9.0 °C(Predicted)
Density 
1.05
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Sparingly), Ethyl Acetate (Slightly)
pka
16.20±0.60(Predicted)
form 
Solid
color 
White
CAS DataBase Reference
19982-07-1(CAS DataBase Reference)
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Safety

HS Code 
2902190000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2653
Product name
N-Acetyl-3,5-dimethyl-1-adamantanamine
Purity
>97.0%(GC)
Packaging
1g
Price
$208
Updated
2025/07/31
TCI Chemical
Product number
A2653
Product name
N-Acetyl-3,5-dimethyl-1-adamantanamine
Purity
>97.0%(GC)
Packaging
5g
Price
$734
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
CHM0006455
Product name
1-ACTAMIDO-3,5-DIMETHYLADMANTANE
Purity
95.00%
Packaging
1G
Price
$1770.62
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
19232
Product name
N-AcetylMemantine
Packaging
1g
Price
$1960
Updated
2021/12/16
Biosynth Carbosynth
Product number
IA11847
Product name
N-Acetylmemantine
Packaging
5G
Price
$200
Updated
2021/12/16
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1-Actamido-3,5-dimethyladmantane Chemical Properties,Usage,Production

Chemical Properties

1-Actamido-3,5-dimethyladmantane is White Solid

Uses

1-Actamido-3,5-dimethyladmantane is an intermediate used for preparation of Memantine (M218000).

Synthesis

707-37-9

75-05-8

19982-07-1

[0063] 1.00 g (5.50 mmol) of 3,5-dimethyl-1-adamantanol, 0.46 g (11.1 mmol) of acetonitrile, and 9.61 g of homotrimethylbenzene were added to a test tube with an outer diameter of 30 mm and mixed well. Subsequently, 1.12 g (11.1 mmol) of 97% concentrated sulfuric acid was slowly added dropwise to the mixed solution in the test tube to form a reaction solution. The reaction solution was stirred at a constant temperature at 30°C for 3 hours to promote the reaction. Upon completion of the reaction, 6.09 g of water was added to the reaction solution to quench the reaction, and the aqueous phase was removed by aqueous washing to obtain a homotrimethylbenzene solution containing 1-acetamido-3,5-dimethyladamantane (reaction yield: 80.4%). Next, 0.71 g of sodium hydroxide hydrate and 9.61 g of 1-hexanol were added to this solution to prepare a reaction solution. The reaction solution was stirred at 130 °C for 18 h to achieve hydrolysis of 1-acetamido-3,5-dimethyladamantane. Finally, the reaction solution was analyzed by gas chromatography (GC) to confirm the generation of memantine (reaction yield: 96.2%).

References

[1] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 867 - 871
[2] Zhurnal Organicheskoi Khimii, 1982, vol. 18, # 5, p. 1001 - 1005
[3] Patent: EP2949643, 2015, A1. Location in patent: Paragraph 0063

1-Actamido-3,5-dimethyladmantane Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Actamido-3,5-dimethyladmantane manufacturers

Dideu Industries Group Limited
Product
1-Actamido-3,5-dimethyladmantane 19982-07-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2025-09-19
Wuhan JiyunZen Tech Co., Ltd.
Product
1-Actamido-3,5-dimethyladmantane 19982-07-1
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-30
Henan Aochuang Chemical Co.,Ltd.
Product
1-Actamido-3,5-dimethyladmantane 19982-07-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-12

19982-07-1, 1-Actamido-3,5-dimethyladmantaneRelated Search:

ETHANE Dacthal Dimethyl fumarate Dimethyl carbonate Dimethyl sulfate Dimethyl sulfoxide Acetamide Acetaminophen N,N-Dimethylformamide Dimethyl ether Dimethyl phthalate 1-Hydroxy-3-amino-5,7-dimethyladamantane hydrochloride Tricyclo[3.3.1.13,7]decan-1-aMine, 3,5,7-triMethyl-, hydrochloride 3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride Memantine Lactose Adduct Memantine Related Compound 1 Adamantane 1-Actamido-3,5-dimethyladmantane

  • n-(3,5-dimethyl-1-adamantyl)-acetamide
  • 1-ACETAMIDO-3,5-DIMETHYLADMANTANE
  • 1-Acetamido-3,5-dimethyladamantane
  • 1-acetate amino-3，5- Dimethyl Adamantane
  • 1. 1-actamido-3,5-dimethyladmantane
  • N-Acetyl Memantine
  • AcetylaMino-3,5-diMethyladaMantane
  • Acetamide,N-(3,5-dimethyltricyclo[3.3.1.13,7]dec-1-yl)-
  • N-Acetyl-3,5-diMethyl-1-adaMantanaMine
  • 1-actamido-3,5-dimethyladmantane
  • N-(3,5-DiMethyltricyclo[3.3.1.13,7]dec-1-yl)acetaMide
  • 1-N-AcetylaMino-3,5-diMethyladaMantane
  • N-(3,5-diMethyladaMantan-1-yl)acetaMide
  • MeMantine IMpurity C
  • <i>N</i>-Acetyl-3,5-dimethyl-1-adamantanamine
  • Memantine impurity E
  • N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)acetamide
  • 1-Actamido-3,5-dimethyladamantane
  • Memantine Acetyl Impurity
  • Acetyl memantine
  • Memantine Impurity 14(N-Acetyl Memantine)
  • Memantine Impurity C (N-Acetyl Memantine)
  • N-Acetyl-3,5-dimethyl-1-adamantanamine &gt
  • Memantine Related Compound F
  • Memantine N-Acetyl
  • Memantine Impurity C (N-Acetyl
  • Memantine Impurity 1 (N-Acetyl Memantine)
  • N-Acetyl-3,5-dimethyl-1-adamantanamine, ≥ 97.0%
  • Memantine Hydrochloride Impurity C
  • 1-Acylamino-3,5-dimethyladamantane
  • 19982-07-1
  • Amines
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