metiazinic acid Property

Melting point:

146℃

Boiling point:

482.6±44.0 °C(Predicted)

Density 

1.2237 (rough estimate)

refractive index 

1.7500 (estimate)

pka

4.12±0.10(Predicted)

Water Solubility 

31mg/L(30 ºC)

Safety

Toxicity

LD50 in mice, rats (mg/kg): 800, ~500 orally (Joulou)

Hazard and Precautionary Statements (GHS)

metiazinic acid Chemical Properties,Usage,Production

Originator

Soripan,Specia,France,1970

Definition

ChEBI: Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group.

Manufacturing Process

10-Methyl-3-acetylphenthiazine is prepared in accordance with G. Cauquil and A. Casadevall, Bull. Soc.Chim., p 768 (1955). (10-Methyl-3-phenthiazinyl)acetic acid (MP 146°C; 21.4 g) is prepared by Willgerodt's reaction (action of sulfur and morpholine, followed by hydrolysis) employing 10-methyl-3-acetylphenthiazine as starting material.

Therapeutic Function

Antiinflammatory

Trade name

Roimal (Kantoishi, Japan), Soripal (Torii, Japan).

Synthesis

Metiazinic acid is prepared via the Willgerodt reaction (sulfur and morpholine) from 2-acetyl-10-methylphenothiazine.

Dosage

Metiazinic acid has been beneficial to arthritis patients when given at a daily dose of 0.75 – 1.5 g/d.