ChemicalBook > CAS DataBase List > 5-bromo-1H-pyrimidin-4-one

5-bromo-1H-pyrimidin-4-one

Uses

Product Name: 5-bromo-1H-pyrimidin-4-one
CAS No.: 19808-30-1
Chemical Name: 5-bromo-1H-pyrimidin-4-one
Synonyms: Einecs 243-334-4;5-Bromo-4-Pyrimidone;5-Bromo-4(3H)-pyrimidone;5-bromo-1H-pyrimidin-4-one;5-Bromo-4(1H)-pyrimidinone;5-BROMOPYRIMIDIN-4(1H)-ONE;5-BroMopyriMidin-4(3H)-one;5-bromo-1H-pyrimidin-6-one;5-Bromopyrimidine-4(3H)-one;5-Bromo-4-hydroxypyrimidine
CBNumber: CB3918304
Molecular Formula: C4H3BrN2O
Formula Weight: 174.98
MOL File: 19808-30-1.mol

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5-bromo-1H-pyrimidin-4-one Property

Melting point:: 198-200℃
Density: 2.00±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 7.25±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C4H3BrN2O/c5-3-1-6-2-7-4(3)8/h1-2H,(H,6,7,8)
InChIKey: CLJIGLPOBRSBNU-UHFFFAOYSA-N
SMILES: C1=NC=C(Br)C(=O)N1
EPA Substance Registry System: 5-Bromo-4(1H)-pyrimidinone (19808-30-1)

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Safety

TSCA: Yes
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B688043
Product name: 5-Bromopyrimidin-4-ol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 068690
Product name: 5-Bromopyrimidin-4-ol
Purity: >95%
Packaging: 1g
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140694
Product name: 5-Bromopyrimidin-4(1H)-one
Packaging: 1g
Price: $74
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-9-87
Product name: 5-Bromopyrimidin-4-ol
Packaging: 1g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140694
Product name: 5-Bromopyrimidin-4(1H)-one
Packaging: 2g
Price: $129
Updated: 2021/12/16

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5-bromo-1H-pyrimidin-4-one Chemical Properties,Usage,Production

Uses

5-Bromopyrimidine-4-one is a pyrimidine derivative and can be used as a pharmaceutical intermediate.

Synthesis

51953-18-5

19808-30-1

Step A: Preparation of 5-bromopyrimidin-4(3H)-one: bromine (16.0 mL, 312 mmol) was slowly added dropwise to a suspension of chloroform (1 L) of 4-hydroxypyrimidine (30 g, 312 mmol) at 0 °C. Methanol (10 mL) was then added as a catalyst and the reaction mixture was stirred at 0 °C for 12 hours. Upon completion of the reaction, the resulting white solid product was collected by filtration, washed sequentially with hexane and ether, and then dried under vacuum to afford 5-bromopyrimidin-4-one (50 g, 91.5% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 11.15 (broad single peak, 1H), 8.42 (single peak, 1H), 8.40 (single peak, 1H).

References

[1] Patent: US2007/238726, 2007, A1. Location in patent: Page/Page column 75
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 16, p. 3905 - 3912
[3] Journal of the Chemical Society, 1955, p. 3478,3481
[4] Patent: WO2013/111105, 2013, A1. Location in patent: Page/Page column 125

5-bromo-1H-pyrimidin-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-1H-pyrimidin-4-one Suppliers

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View Lastest Price from 5-bromo-1H-pyrimidin-4-one manufacturers

Dideu Industries Group Limited

Product: 5-bromo-1H-pyrimidin-4-one 19808-30-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-bromo-1H-pyrimidin-4-one 19808-30-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-bromo-1H-pyrimidin-4-one 19808-30-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

19808-30-1, 5-bromo-1H-pyrimidin-4-oneRelated Search:

5-bromo-1H-pyrimidin-4-one 5-BROMO-2,4-DIMETHOXYPYRIMIDINE 5-Bromo-4,6-dihydroxypyrimidine 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE 5-Bromo-4,6-dimethoxypyrimidine 5-bromo-2-methylsulfanyl-3H-pyrimidin-4-one 2 , 4-BIS(BENZYLOXY)-5-BROMOPYRIMIDINE 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE 5-Bromopyrimidine 5-BROMO-2,4-DIAMINO-6-HYDROXYPYRIMIDINE 5-bromo-2-phenylpyrimidin-4-ol 5-bromo-6-tert-butyl-4-pyrimidinol 6-AMINO-5-BROMO-2-(ETHYLTHIO)PYRIMIDIN-4-OL 5-bromo-2-(methylsulfanyl)pyrimidin-4-ol 5-BROMO-6-METHYLPYRIMIDIN-4-OL N-(5-BROMO-1,4-DIHYDRO-4-OXO-6-PHENYL-2-PYRIMIDINYL)-ACETAMIDE N-(5-BROMO-4-METHOXY-6-METHYLPYRIMIDIN-2-YL)ACETAMIDE

4(1H)-Pyrimidinone, 5-bromo-

4(3H)-Pyrimidinone, 5-bromo-

5-Bromo-4-hydroxypyrimidine

Einecs 243-334-4

5-bromo-1H-pyrimidin-4-one

5-Bromo-4-Pyrimidone

5-BROMOPYRIMIDIN-4(1H)-ONE

5-Bromo-3,4-dihydropyrimidine-4-one

5-Bromo-4(1H)-pyrimidinone

5-Bromopyrimidine-4(3H)-one

5-BroMopyriMidin-4(3H)-one

5-bromo-3,4-dihydropyrimidin-4-one

5-BroMo-4-hydroxypyriMidine.1/2H2SO4

5-bromo-1H-pyrimidin-6-one

5-Bromo-4(3H)-pyrimidone

5-Bromopyrimidin-4(1H)-one,97%

5-bromo-1H-pyrimidin-4-one ISO 9001：2015 REACH

19808-30-1