2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
- Product Name
- 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
- CAS No.
- 56741-95-8
- Chemical Name
- 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
- Synonyms
- U-54461;U 54461S;PNU-54461;NSC 149027;bropirimine;Bromopilimine;5-BroMo-6-phenylisocytosine;2-Amino-5-bromo-6-phenylpyrimidin-4-ol;2-AMino-5-broMo-6-phenyl-4-pyriMidinol;2-AMino-5-broMo-6-phenyl-4-pyriMidinone
- CBNumber
- CB5225165
- Molecular Formula
- C10H8BrN3O
- Formula Weight
- 266.09
- MOL File
- 56741-95-8.mol
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Property
- Melting point:
- 285-287° (Stevens); mp 246-248° (Brown, Stevens)
- Boiling point:
- 389.7±52.0 °C(Predicted)
- Density
- 1.6292 (rough estimate)
- refractive index
- 1.6520 (estimate)
- storage temp.
- room temp
- solubility
- DMSO: ≥5mg/mL (warm DMSO)
- form
- powder
- pka
- 3.18; 8.53(at 25℃)
- color
- white to beige
- Water Solubility
- 7.8mg/L(37 ºC)
N-Bromosuccinimide Price
- Product number
- SML0218
- Product name
- Bropirimine
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 29440
- Product name
- Bropirimine
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 29440
- Product name
- Bropirimine
- Packaging
- 25mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 29440
- Product name
- Bropirimine
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29440
- Product name
- Bropirimine
- Packaging
- 50mg
- Price
- $199
- Updated
- 2024/03/01
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Chemical Properties,Usage,Production
Description
Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).
Uses
Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.
Uses
Bropirimine, an immunostimulating agent and toll like receptor (TLR7) agonist, is used in comparison with other TLR7 agonists such as imiquimod, R-848, loxoribine in interferon cell signaling research. Bropirimine may be used in experimental autoimmune encephalomyelitis (EAE) and bladder cancer research.
Definition
ChEBI: Bropirimine is a member of pyrimidines.
Biochem/physiol Actions
Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.
storage
Desiccate at RT
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE manufacturers
- Product
- 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 56741-95-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-01
- Product
- Bropirimine 56741-95-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 800 ton
- Release date
- 2020-04-30