ChemicalBook > CAS DataBase List > 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

Product Name
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
CAS No.
56741-95-8
Chemical Name
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
Synonyms
U-54461;U 54461S;PNU-54461;NSC 149027;bropirimine;Bromopilimine;5-BroMo-6-phenylisocytosine;2-Amino-5-bromo-6-phenylpyrimidin-4-ol;2-AMino-5-broMo-6-phenyl-4-pyriMidinol;2-AMino-5-broMo-6-phenyl-4-pyriMidinone
CBNumber
CB5225165
Molecular Formula
C10H8BrN3O
Formula Weight
266.09
MOL File
56741-95-8.mol
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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Property

Melting point:
285-287° (Stevens); mp 246-248° (Brown, Stevens)
Boiling point:
389.7±52.0 °C(Predicted)
Density 
1.6292 (rough estimate)
refractive index 
1.6520 (estimate)
storage temp. 
room temp
solubility 
DMSO: ≥5mg/mL (warm DMSO)
form 
powder
pka
3.18; 8.53(at 25℃)
color 
white to beige
Water Solubility 
7.8mg/L(37 ºC)
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Safety

Hazard Codes 
Xn
Risk Statements 
63-62
WGK Germany 
3
RTECS 
UW7351300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P281Use personal protective equipment as required.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0218
Product name
Bropirimine
Purity
≥98% (HPLC)
Packaging
10mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
29440
Product name
Bropirimine
Packaging
10mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
29440
Product name
Bropirimine
Packaging
25mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
29440
Product name
Bropirimine
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29440
Product name
Bropirimine
Packaging
50mg
Price
$199
Updated
2024/03/01
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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Chemical Properties,Usage,Production

Description

Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).

Uses

Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.

Uses

Bropirimine, an immunostimulating agent and toll like receptor (TLR7) agonist, is used in comparison with other TLR7 agonists such as imiquimod, R-848, loxoribine in interferon cell signaling research. Bropirimine may be used in experimental autoimmune encephalomyelitis (EAE) and bladder cancer research.

Definition

ChEBI: Bropirimine is a member of pyrimidines.

Biochem/physiol Actions

Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.

storage

Desiccate at RT

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
Tel
21-57721279
Fax
QQ:14057904
Email
sales@shydchem.com.cn
Country
China
ProdList
982
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56
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
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LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
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57
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
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China
ProdList
1073
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
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Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9346
Advantage
58
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View Lastest Price from 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 56741-95-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Shaanxi Dideu Medichem Co. Ltd
Product
Bropirimine 56741-95-8
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

56741-95-8, 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINERelated Search:


  • 2-Amino-5-bromo-6-phenylpyrimidin-4(3H)-one
  • 2-AMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE
  • 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
  • 2-Amino-5-bromo-6-phenylpyrimidin-4-ol
  • 2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one
  • 5-Bromo-6-phenyl-2,3-dihydro-2-iminopyrimidin-4(1H)-one
  • PNU-54461
  • U-54461
  • 2-AMino-5-broMo-6-phenyl-4(3H)-pyriMidinone
  • 2-AMino-5-broMo-6-phenyl-4-pyriMidinol
  • 2-AMino-5-broMo-6-phenyl-4-pyriMidinone
  • 5-BroMo-2,3-dihydro-2-iMino-6-phenyl-4(1H)-pyriMidinone
  • 5-BroMo-6-phenylisocytosine
  • NSC 149027
  • 4(3H)-PyriMidinone, 2-aMino-5-broMo-6-phenyl-
  • 2-Amino-5-bromo-4-phenyl-6-hydroxypyrimidine
  • U 54461S
  • 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinon
  • 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinone
  • bropirimine
  • 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone
  • 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one
  • 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP
  • carcinoma,antitumour,Bropirimine,tract,immunostimulant,Inhibitor,differentiation,Toll-like Receptor (TLR),urinary,inhibit
  • Bromopilimine
  • 56741-95-8
  • C10H8BrN3O
  • Heterocycle-Pyrimidine series
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals