ChemicalBook > CAS DataBase List > 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

Product Name
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
CAS No.
56741-95-8
Chemical Name
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
Synonyms
U-54461;U 54461S;PNU-54461;NSC 149027;bropirimine;Bromopilimine;5-BroMo-6-phenylisocytosine;2-Amino-5-bromo-6-phenylpyrimidin-4-ol;2-AMino-5-broMo-6-phenyl-4-pyriMidinol;2-AMino-5-broMo-6-phenyl-4-pyriMidinone
CBNumber
CB5225165
Molecular Formula
C10H8BrN3O
Formula Weight
266.09
MOL File
56741-95-8.mol
More
Less

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Property

Melting point:
285-287° (Stevens); mp 246-248° (Brown, Stevens)
Boiling point:
389.7±52.0 °C(Predicted)
Density 
1.6292 (rough estimate)
refractive index 
1.6520 (estimate)
storage temp. 
room temp
solubility 
DMSO: ≥5mg/mL (warm DMSO)
form 
powder
pka
3.18; 8.53(at 25℃)
color 
white to beige
Water Solubility 
7.8mg/L(37 ºC)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
63-62
WGK Germany 
3
RTECS 
UW7351300
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P281Use personal protective equipment as required.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0218
Product name
Bropirimine
Purity
≥98% (HPLC)
Packaging
10mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
29440
Product name
Bropirimine
Packaging
10mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
29440
Product name
Bropirimine
Packaging
25mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
29440
Product name
Bropirimine
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29440
Product name
Bropirimine
Packaging
50mg
Price
$199
Updated
2024/03/01
More
Less

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Chemical Properties,Usage,Production

Description

Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).

Uses

Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.

Uses

Bropirimine, an immunostimulating agent and toll like receptor (TLR7) agonist, is used in comparison with other TLR7 agonists such as imiquimod, R-848, loxoribine in interferon cell signaling research. Bropirimine may be used in experimental autoimmune encephalomyelitis (EAE) and bladder cancer research.

Definition

ChEBI: Bropirimine is a member of pyrimidines.

Biochem/physiol Actions

Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.

storage

Desiccate at RT

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Suppliers

Canada 2 China 57 France 1 Germany 1 India 1 Russia 1 United Kingdom 6 United States 18 Global 87
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
Tel
21-57721279
Fax
QQ：14057904
Email
sales@shydchem.com.cn
Country
China
ProdList
982
Advantage
56
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1076
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9352
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9798
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27322
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
3444
Advantage
55
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15495
Advantage
58
Suzhou Nuoouman Biological Technology Co., Ltd.
Tel
13913522962
Email
180642609@qq.com
Country
China
ProdList
4965
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52712
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
21450
Advantage
58
wuhan Dekray Biomedical Technology Co.,Ltd
Tel
027-027-69818188 18221423799
Email
1503407886@qq.com
Country
China
ProdList
1406
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55827
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
29016
Advantage
58
KARMEL TECHNOLOGY (HK) CO.,LIMITED
Tel
+8618795957998
Email
karmelhk@126.com
Country
CHINA
ProdList
2886
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58
Wuxi Kehua Biological Technology Co., Ltd.
Tel
0510-0510-86838766
Email
2258830676@qq.com
Country
China
ProdList
3824
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49390
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49323
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569266 15319487004
Fax
029-88380327
Email
1015@dideu.com
Country
China
ProdList
2263
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
chenjw@absin.cn
Country
China
ProdList
24734
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26033
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8141
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
9946
Advantage
58
Hubei Co-prosperity Medicine Technonlogy Co., Ltd
Tel
2383948258 19172820304
Email
2383948258@qq.com
Country
China
ProdList
12994
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
39997
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18488
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24131
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55013243 15324716602
Email
2853979810@qq.com
Country
China
ProdList
9799
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 15162312715
Email
sales@szzxbio.com
Country
China
ProdList
2999
Advantage
58
Nanjing Puruida Pharmaceutical Technology Co., Ltd.
Tel
15905142898
Email
sales@prdchem.com
Country
China
ProdList
966
Advantage
58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Tel
18049165724 13186333400
Email
cuichengbio@163.com
Country
China
ProdList
2606
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50471
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
8740
Advantage
58
Baoji Didu Pharmaceutical and Chemical Co., Ltd
Tel
17691182729 15991417702
Email
1065@dideu.com
Country
China
ProdList
10011
Advantage
58
RD International Technology Co., Limited
Tel
18988968278
Email
sales@ubiochem.com
Country
China
ProdList
9146
Advantage
58
Shanghai Acmec Biochemical Technology Co., Ltd.
Tel
+undefined18621343501
Email
product@acmec-e.com
Country
China
ProdList
33349
Advantage
58
LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
43348
Advantage
58
ZHEJIANG JIUZHOU CHEM CO., LTD
Tel
+86-0576225566889 +86-13454675544
Email
admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com
Country
China
ProdList
20000
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6846
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
More
Less

View Lastest Price from 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 56741-95-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Shaanxi Dideu Medichem Co. Ltd
Product
Bropirimine 56741-95-8
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

56741-95-8, 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINERelated Search:

Bromisoval Neostigmine bromide Mestinon 2-Amino-4-hydroxy-6-phenylpyrimidine 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 2-Amino-5-bromopyrimidine 5-BROMO-6-METHYLPYRIMIDIN-4-OL 5-Bromo-4-phenylpyrimidine 2-Amino-4-methyl-5-bromopyrimidine 5-bromo-1H-pyrimidin-4-one 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE N2-ACETYLAMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE 2-amino-5-bromo-4-pyrimidinol Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI)

  • 2-Amino-5-bromo-6-phenylpyrimidin-4(3H)-one
  • 2-AMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE
  • 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
  • 2-Amino-5-bromo-6-phenylpyrimidin-4-ol
  • 2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one
  • 5-Bromo-6-phenyl-2,3-dihydro-2-iminopyrimidin-4(1H)-one
  • PNU-54461
  • U-54461
  • 2-AMino-5-broMo-6-phenyl-4(3H)-pyriMidinone
  • 2-AMino-5-broMo-6-phenyl-4-pyriMidinol
  • 2-AMino-5-broMo-6-phenyl-4-pyriMidinone
  • 5-BroMo-2,3-dihydro-2-iMino-6-phenyl-4(1H)-pyriMidinone
  • 5-BroMo-6-phenylisocytosine
  • NSC 149027
  • 4(3H)-PyriMidinone, 2-aMino-5-broMo-6-phenyl-
  • 2-Amino-5-bromo-4-phenyl-6-hydroxypyrimidine
  • U 54461S
  • 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinon
  • 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinone
  • bropirimine
  • 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone
  • 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one
  • 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP
  • carcinoma,antitumour,Bropirimine,tract,immunostimulant,Inhibitor,differentiation,Toll-like Receptor (TLR),urinary,inhibit
  • Bromopilimine
  • 56741-95-8
  • C10H8BrN3O
  • Heterocycle-Pyrimidine series
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals