2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

ChemicalBook > CAS DataBase List > 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

Product Name: 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
CAS No.: 56741-95-8
Chemical Name: 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
Synonyms: U-54461;U 54461S;PNU-54461;NSC 149027;bropirimine;Bromopilimine;5-BroMo-6-phenylisocytosine;2-Amino-5-bromo-6-phenylpyrimidin-4-ol;2-AMino-5-broMo-6-phenyl-4-pyriMidinol;2-AMino-5-broMo-6-phenyl-4-pyriMidinone
CBNumber: CB5225165
Molecular Formula: C10H8BrN3O
Formula Weight: 266.09
MOL File: 56741-95-8.mol

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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Property

Melting point:: 285-287° (Stevens); mp 246-248° (Brown, Stevens)
Boiling point:: 389.7±52.0 °C(Predicted)
Density: 1.6292 (rough estimate)
refractive index: 1.6520 (estimate)
storage temp.: room temp
solubility: DMSO: ≥5mg/mL (warm DMSO)
form: powder
pka: 3.18; 8.53(at 25℃)
color: white to beige
Water Solubility: 7.8mg/L(37 ºC)

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Safety

Hazard Codes: Xn
Risk Statements: 63-62
WGK Germany: 3
RTECS: UW7351300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H361Suspected of damaging fertility or the unborn child
Precautionary statements: P281Use personal protective equipment as required.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0218
Product name: Bropirimine
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 29440
Product name: Bropirimine
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 29440
Product name: Bropirimine
Packaging: 25mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29440
Product name: Bropirimine
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29440
Product name: Bropirimine
Packaging: 50mg
Price: $199
Updated: 2024/03/01

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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Chemical Properties,Usage,Production

Description

Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).

Uses

Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.

Uses

Bropirimine, an immunostimulating agent and toll like receptor (TLR7) agonist, is used in comparison with other TLR7 agonists such as imiquimod, R-848, loxoribine in interferon cell signaling research. Bropirimine may be used in experimental autoimmune encephalomyelitis (EAE) and bladder cancer research.

Definition

ChEBI: Bropirimine is a member of pyrimidines.

Biochem/physiol Actions

Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.

storage

Desiccate at RT

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Suppliers

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View Lastest Price from 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE manufacturers

Dideu Industries Group Limited

Product: 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 56741-95-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

Shaanxi Dideu Medichem Co. Ltd

Product: Bropirimine 56741-95-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

56741-95-8, 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINERelated Search:

Bromisoval Neostigmine bromide Mestinon 2-Amino-4-hydroxy-6-phenylpyrimidine 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 2-Amino-5-bromopyrimidine 5-BROMO-6-METHYLPYRIMIDIN-4-OL 5-Bromo-4-phenylpyrimidine 2-Amino-4-methyl-5-bromopyrimidine 5-bromo-1H-pyrimidin-4-one 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE N2-ACETYLAMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE 2-amino-5-bromo-4-pyrimidinol Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI)

2-Amino-5-bromo-6-phenylpyrimidin-4(3H)-one

2-AMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

2-Amino-5-bromo-6-phenylpyrimidin-4-ol

2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one

5-Bromo-6-phenyl-2,3-dihydro-2-iminopyrimidin-4(1H)-one

PNU-54461

U-54461

2-AMino-5-broMo-6-phenyl-4(3H)-pyriMidinone

2-AMino-5-broMo-6-phenyl-4-pyriMidinol

2-AMino-5-broMo-6-phenyl-4-pyriMidinone

5-BroMo-2,3-dihydro-2-iMino-6-phenyl-4(1H)-pyriMidinone

5-BroMo-6-phenylisocytosine

NSC 149027

4(3H)-PyriMidinone, 2-aMino-5-broMo-6-phenyl-

2-Amino-5-bromo-4-phenyl-6-hydroxypyrimidine

U 54461S

2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinon

2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinone

bropirimine

2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone

2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP

carcinoma,antitumour,Bropirimine,tract,immunostimulant,Inhibitor,differentiation,Toll-like Receptor (TLR),urinary,inhibit

Bromopilimine

56741-95-8

C10H8BrN3O

Heterocycle-Pyrimidine series

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals