ethaverine hydrochloride

Product Name: ethaverine hydrochloride
CAS No.: 985-13-7
Chemical Name: ethaverine hydrochloride
Synonyms: Isovex;Cebral;Ethaquin;Consenil;Balborin;Papetherine;Barbonin hydrochloride;ethaverine hydrochloride;Drotaveraldine Impurity A;Ethylpapaverin hydrochloride
CBNumber: CB3919169
Molecular Formula: C24H29NO4.ClH
Formula Weight: 431.957
MOL File: 985-13-7.mol

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ethaverine hydrochloride Property

Melting point:: 186-188° (dec)
form: Solid
color: Light yellow to yellow
EPA Substance Registry System: Ethaverine hydrochloride (985-13-7)

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Safety

RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup: II
Toxicity: LD50 scu-mus: 660 mg/kg THERAP5,69,50

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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ethaverine hydrochloride Chemical Properties,Usage,Production

Uses

Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease[1][2][3].

Safety Profile

Poison by intravenous route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic vapors of NOx, HCl, and Clí

in vivo

Ethaverine hydrochloride (2-10 mg/kg, intravenous infusion, i.v.) causes significant elevation of endocochlear potential in guinea pigs^[4].
Ethaverine (1-10 mg/kg, i.v.) inhibits atrioventricular conduction and heart rate in the anaesthetized dog^[5].

Animal Model:	Dog^[5]
Dosage:	1 and 10 mg/kg
Administration:	i.v.
Result:	Inhibited atrioventricular conduction and heart rate.

References

[1] Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5. PMID:1658607
[2] Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6. DOI:10.1016/0006-2952(94)90399-9
[3] Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5. DOI:10.1248/bpb.24.103
[4] Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107(4):227-9. DOI:10.1001/archotol.1981.00790400029006
[5] Lacroix P, et al. [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French. PMID:962426
[6] Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40. DOI:10.1248/bpb.24.838

ethaverine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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ethaverine hydrochloride Suppliers

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985-13-7, ethaverine hydrochlorideRelated Search:

Levofloxacin hydrochloride PAPAVERINE 7-METHOXY-ISOQUINOLINE papaveroline 6-Desmethyl Papaverine 2-Benzylpyridine 6,7-DIMETHOXYISOQUINOLINE 6-Methoxyisoquinoline 1-METHYLISOQUINOLINE Isoquinolin-6-ol Papaverine hydrochloride ethaverine 7-Hydroxyisoquinoline 1-Benzylisoquinoline ethaverine hydrochloride

ethaverine hydrochloride

Balborin

Ethylpapaverin hydrochloride

6,7-Diethoxy-1-(3,4-diethoxybenzyl)isoquinoline hydrochloride

Barbonin hydrochloride

Cebral

Consenil

Ethaquin

Isoquinoline, 1-(3,4-diethoxybenzyl)-6,7-diethoxy-, hydrochloride

Isoquinoline, 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-, hydrochloride

Isovex

Papetherine

3-methoxyestra-1,3,5(10),8,14-pentaen-17-one

Drotaveraldine Impurity A

Ethaverine hydrochloride, 10 mM in DMSO

985-13-7

C24H29NO4ClH