ChemicalBook > CAS DataBase List > Boc-DL-3-Aminoisobutyric acid

Boc-DL-3-Aminoisobutyric acid

Uses

Product Name: Boc-DL-3-Aminoisobutyric acid
CAS No.: 16948-10-0
Chemical Name: Boc-DL-3-Aminoisobutyric acid
Synonyms: Boc-DL-3-Aminoisobutyric acid;3-(BOC-AMINO)-2-METHYLPROPANOIC ACID;REF DUPL: Boc-DL-3-Aminoisobutyric acid;3-(tert-butoxycarbonyl)-2-methylpropanoic acid;3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic;N-((tert-Butoxy)carbonyl)-DL-3-aminoisobutyric acid;3-(tert-butoxycarbonylamino)-2-methylpropanoic acid;Boc-DL-3-AMinoisobutyric acid Boc-DL-3-AMinoisobutyric acid;2-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;Propanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-Methyl-, (±)-
CBNumber: CB3966754
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 16948-10-0.mol

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Boc-DL-3-Aminoisobutyric acid Property

Melting point:: 89-90℃ (ethyl ether pentane )
Boiling point:: 339.5±25.0 °C(Predicted)
Density: 1.101±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
pka: 4.53±0.10(Predicted)
form: crystalline powder
color: White
optical activity: Consistent with structure

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Safety

HazardClass: IRRITANT
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

TRC

Product number: B943473
Product name: 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoicAcid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142977
Product name: 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Matrix Scientific

Product number: 041464
Product name: Boc-DL-beta-Aib-OH
Packaging: 1g
Price: $163
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142977
Product name: 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid
Packaging: 1g
Price: $210
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142977
Product name: 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid
Packaging: 2g
Price: $366
Updated: 2021/12/16

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Boc-DL-3-Aminoisobutyric acid Chemical Properties,Usage,Production

Uses

BOC-DL-3-aminoisobutyric acid is a product in which the amino group of 3-aminoisobutyric acid is protected by a tert-butoxycarbonyl (BOC) group, and it can be used as an intermediate in the synthesis of pharmaceuticals and chemicals.

Synthesis

10569-72-9

24424-99-5

16948-10-0

GENERAL STEPS: DL-3-aminoisobutyric acid (CAS No. [10569-72-9], 5 g, 47.52 mmol) was dissolved in 2N NaOH solution (24.7 mL), and a solution of tetrahydrofuran (THF, 75 mL) of di-tert-butyl dicarbonate (Boc2O, 11.73 g, 53.22 mmol) was added slowly dropwise with the cooling of a cold water bath, controlling the The reaction temperature was below 30 °C. The reaction mixture was stirred at room temperature for 18 hours and then concentrated under reduced pressure. The concentrate was diluted with water (75 mL) and washed with methyl tert-butyl ether (MTBE, 3 x 150 mL). The aqueous phase was acidified to pH 3 with 100 g/L citric acid solution (150 mL) and subsequently extracted with ethyl acetate (EtOAc, 3 × 150 mL). The organic phases were combined, washed with water (3×45 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford 9.4 g of the target product 3-((tert-butoxycarbonyl)amino)-2-methylpropanoic acid (Compound 11) as a colorless oil in 97% yield. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6, δ, ppm): 1.01 (d, J = 7.1 Hz, 3H); 1.38 (s, 9H); 2.48 (m, 1H); 2.91 (dt, J = 6.1, 6.5 and 13.5 Hz, 1H); 3.15 (ddd, J = 6.1, 7.4 and 13.5 Hz , 1H); 6.80 (t, J = 6.1 Hz, 1H); 12.15 (broad s, 1H).

References

[1] Journal of Organic Chemistry, 2001, vol. 66, # 20, p. 6541 - 6544
[2] Patent: WO2017/76998, 2017, A1. Location in patent: Page/Page column 163
[3] Patent: EP2380890, 2011, A1. Location in patent: Page/Page column 19
[4] Patent: CN108341752, 2018, A. Location in patent: Paragraph 0482; 0483; 0484; 0485
[5] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788,15

Boc-DL-3-Aminoisobutyric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-DL-3-Aminoisobutyric acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Boc-DL-3-Aminoisobutyric acid 16948-10-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-01-03

Career Henan Chemical Co

Product: Boc-DL-3-Aminoisobutyric acid 16948-10-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-01

16948-10-0, Boc-DL-3-Aminoisobutyric acidRelated Search:

BOC-1,2-CIS-ACHC-OH DL-3-Aminoisobutyric acid cis-2-(tert-Butoxycarbonylamino)-1-cyclopentanecarboxylic acid N-Boc-3-carboethoxy-4-piperidone L-1-Boc-Nipecotic acid 1-N-Boc-3-Azetidinecarboxylic acid 2-(N,N-DIMETHYLAMINOMETHYL)PHENYLBORONIC ACID BOC-1,2-TRANS-ACHC-OH 4-(4-METHOXY-PHENYL)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER trans-1-Boc-4-(4-chlorophenyl)-3-pyrrolidinecarboxylic acid Boc-DL-3-Aminoisobutyric acid 1-BOC-PIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-4-PHENYLPYRROLINE-3-CARBOXYLIC ACID 5-PHENYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 1-(TERT-BUTOXYCARBONYL)-4-PHENYLPIPERIDINE-3-CARBOXYLIC ACID 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 1-[(TERT-BUTYL)OXYCARBONYL]-4-(2-CHLOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-4-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE-3-CARBOXYLIC ACID

Boc-DL-3-Aminoisobutyric acid

3-(tert-butoxycarbonylamino)-2-methylpropanoic acid

REF DUPL: Boc-DL-3-Aminoisobutyric acid

Boc-DL-3-AMinoisobutyric acid Boc-DL-3-AMinoisobutyric acid

Propanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-Methyl-, (±)-

3-(BOC-AMINO)-2-METHYLPROPANOIC ACID

3-(tert-butoxycarbonyl)-2-methylpropanoic acid

2-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

N-((tert-Butoxy)carbonyl)-DL-3-aminoisobutyric acid

3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic

16948-10-0