Boc-DL-3-Aminoisobutyric acid
Uses- Product Name
- Boc-DL-3-Aminoisobutyric acid
- CAS No.
- 16948-10-0
- Chemical Name
- Boc-DL-3-Aminoisobutyric acid
- Synonyms
- Boc-DL-3-Aminoisobutyric acid;3-(BOC-AMINO)-2-METHYLPROPANOIC ACID;REF DUPL: Boc-DL-3-Aminoisobutyric acid;3-(tert-butoxycarbonyl)-2-methylpropanoic acid;3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic;N-((tert-Butoxy)carbonyl)-DL-3-aminoisobutyric acid;3-(tert-butoxycarbonylamino)-2-methylpropanoic acid;Boc-DL-3-AMinoisobutyric acid Boc-DL-3-AMinoisobutyric acid;2-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;Propanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-Methyl-, (±)-
- CBNumber
- CB3966754
- Molecular Formula
- C9H17NO4
- Formula Weight
- 203.24
- MOL File
- 16948-10-0.mol
Boc-DL-3-Aminoisobutyric acid Property
- Melting point:
- 89-90℃ (ethyl ether pentane )
- Boiling point:
- 339.5±25.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- pka
- 4.53±0.10(Predicted)
- form
- crystalline powder
- color
- White
- optical activity
- Consistent with structure
Safety
- HazardClass
- IRRITANT
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
N-Bromosuccinimide Price
- Product number
- B943473
- Product name
- 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB142977
- Product name
- 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 041464
- Product name
- Boc-DL-beta-Aib-OH
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
- Product number
- FB142977
- Product name
- 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid
- Packaging
- 1g
- Price
- $210
- Updated
- 2021/12/16
- Product number
- FB142977
- Product name
- 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid
- Packaging
- 2g
- Price
- $366
- Updated
- 2021/12/16
Boc-DL-3-Aminoisobutyric acid Chemical Properties,Usage,Production
Uses
BOC-DL-3-aminoisobutyric acid is a product in which the amino group of 3-aminoisobutyric acid is protected by a tert-butoxycarbonyl (BOC) group, and it can be used as an intermediate in the synthesis of pharmaceuticals and chemicals.
Synthesis
10569-72-9
24424-99-5
16948-10-0
GENERAL STEPS: DL-3-aminoisobutyric acid (CAS No. [10569-72-9], 5 g, 47.52 mmol) was dissolved in 2N NaOH solution (24.7 mL), and a solution of tetrahydrofuran (THF, 75 mL) of di-tert-butyl dicarbonate (Boc2O, 11.73 g, 53.22 mmol) was added slowly dropwise with the cooling of a cold water bath, controlling the The reaction temperature was below 30 °C. The reaction mixture was stirred at room temperature for 18 hours and then concentrated under reduced pressure. The concentrate was diluted with water (75 mL) and washed with methyl tert-butyl ether (MTBE, 3 x 150 mL). The aqueous phase was acidified to pH 3 with 100 g/L citric acid solution (150 mL) and subsequently extracted with ethyl acetate (EtOAc, 3 × 150 mL). The organic phases were combined, washed with water (3×45 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford 9.4 g of the target product 3-((tert-butoxycarbonyl)amino)-2-methylpropanoic acid (Compound 11) as a colorless oil in 97% yield. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6, δ, ppm): 1.01 (d, J = 7.1 Hz, 3H); 1.38 (s, 9H); 2.48 (m, 1H); 2.91 (dt, J = 6.1, 6.5 and 13.5 Hz, 1H); 3.15 (ddd, J = 6.1, 7.4 and 13.5 Hz , 1H); 6.80 (t, J = 6.1 Hz, 1H); 12.15 (broad s, 1H).
References
[1] Journal of Organic Chemistry, 2001, vol. 66, # 20, p. 6541 - 6544
[2] Patent: WO2017/76998, 2017, A1. Location in patent: Page/Page column 163
[3] Patent: EP2380890, 2011, A1. Location in patent: Page/Page column 19
[4] Patent: CN108341752, 2018, A. Location in patent: Paragraph 0482; 0483; 0484; 0485
[5] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788,15
Boc-DL-3-Aminoisobutyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
Boc-DL-3-Aminoisobutyric acid Suppliers
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- Country
- Germany
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View Lastest Price from Boc-DL-3-Aminoisobutyric acid manufacturers
- Product
- Boc-DL-3-Aminoisobutyric acid 16948-10-0
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-01-03
- Product
- Boc-DL-3-Aminoisobutyric acid 16948-10-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-01