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TRIPROLIDINE HYDROCHLORIDE

Product Name
TRIPROLIDINE HYDROCHLORIDE
CAS No.
550-70-9
Chemical Name
TRIPROLIDINE HYDROCHLORIDE
Synonyms
Venen;Entra;Actidil;295 C 51;Actidilat;Pro-entra;Actidilon;Pro-actidil;TRIPROLIDINE HCL;Einecs 208-985-0
CBNumber
CB4100461
Molecular Formula
C19H23ClN2
Formula Weight
314.85
MOL File
550-70-9.mol
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TRIPROLIDINE HYDROCHLORIDE Property

Melting point:
116-118 °C
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Dichloromethane (Slightly), Water (Slightly)
form 
Powder
Water Solubility 
Soluble to 100 mM in water
Stability:
Hygroscopic
CAS DataBase Reference
550-70-9(CAS DataBase Reference)
EPA Substance Registry System
Pyridine, 2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride (550-70-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
3
RTECS 
UT7658000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 oral in rat: 840mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
0662
Product name
trans-Triprolidinehydrochloride
Purity
≥99%(HPLC)
Packaging
100
Price
$79
Updated
2021/12/16
TRC
Product number
T814000
Product name
Triprolidine hydrochloride
Packaging
5g
Price
$150
Updated
2021/12/16
Usbiological
Product number
256961
Product name
trans-Triprolidine hydrochloride
Packaging
5g
Price
$310
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001378
Product name
ACTIDIL
Purity
95.00%
Packaging
10MG
Price
$280.35
Updated
2021/12/16
AK Scientific
Product number
V1639
Product name
Triprolidine hydrochloride
Packaging
5g
Price
$125
Updated
2021/12/16
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TRIPROLIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Actidil,Burroughs-Wellcome,US,1958

Uses

trans-Triprolidine Hydrochloride is a histamine H1 receptor antagonist, which can be used for the prevention of treatment of chronic muscle pain.

Uses

Triprolidine is an antihistaminic agent with anticholinergic properties. Triprolidine is used to treat and prevent symptoms associated with allergies. Triprolidine is also used in combination with cold medicine to provide relief for flu-like symptoms.

Uses

Antihistaminic;H1 antagonist

Definition

ChEBI: A hydrochloride resulting from the formal reaction of equimolar amounts of triprolidine and hydrogen chloride. Its monohydrate is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.

Manufacturing Process

4-Methylacetophenone is first reacted with paraformaldehyde and then with pyrrolidine to give p-methyl-ω-pyrralidinopropiophenone. Atomized lithium (26 g, 3.75 mols) and sodium-dried ether (200 cc) are placed in a 3-liter, 3-necked flask fitted with a Herschberg stirrer, thermometer pocket and a water condenser closed by a calcium chloride tube. A slow stream of dry nitrogen is blown through the flask, which is cooled to - 10°C and n-butyl chloride (138 g, 156 cc, 1.5 mols) is run in with rapid stirring; the mixture is stirred for a further 30 minutes, and then cooled to - 60°C
2-Bromopyridine (193 g, 1.22 mols) is then added dropwise over 20 minutes, the temperature of the reaction mixture being maintained at -50°C. The mixture is stirred for 10 minutes at -50°C and p-methyl-ω- pyrrolidinopropiophenone (112.5 g, 0.5 mol) in dry benzene is then added dropwise over ca 30 minutes, at a temperature of -50°C. The mixture is stirred for a further 2 hours, the temperature being allowed to rise to -30°C but no higher.
The mixture is poured onto excess ice, acidified with concentrated hydrochloric acid, the ether layer separated and extracted with water (1 x 200 cc). The combined aqueous extracts are washed with ether (1 x 200 cc) basified with 0.880 ammonia and extracted with chloroform (3 x 350 cc); the extract is washed with water (2 x 100 cc), dried over sodium sulfate, evaporated, and the residue extracted with boiling light petroleum (BP 60° to 80°C; 10 volumes), filtered hot and evaporated to dryness. The residue is recrystallized from alcohol to give a cream solid (119 g, 80%), MP 117° to 118°C. Recrystallization gives 1-(4-methylphenyl)-1-(2-pyridyl)-3- pyrrolidonopropan-1-ol, MP 119° to 120°C.
1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinopropan-1-ol (10.0 g) is heated in a steam bath for 30 minutes with 85% aqueous sulfuric acid (30 cc). The solution is then poured onto crushed ice, excess of ammonia solution added and the liberated oil extracted with light petroleum (BP 60° to 80°C). The extract is dried over anhydrous sodium sulfate and the solvent evaporated to leave an amber syrup (8.8 g) consisting of the cis and trans isomers of 1-(4- methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene as described in US Patent 2,712,023. The isomers may be separated by base exchange chromatography. The 4-methyl-ω-pyrrolidinopropiophenone required as the starting product for the preparation of the carbinol is prepared by the Mannich reaction (Blicke, Organic Reactions, 1942, vol 1, p 303; Adamson & Billinghurst, Journal of the Chemical Society, 1950,1039) from 4-methylacetophenone and pyrrolidine. The hydrochloride has a MP of 170°C with decomposition.

brand name

Actidil (GlaxoSmithKline); Myidyl (USl).

Therapeutic Function

Antihistaminic

TRIPROLIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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TRIPROLIDINE HYDROCHLORIDE Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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021-50135380
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Shanghai TaoSu Biochemical Technology Co., Ltd.
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Hubei Jusheng Technology Co.,Ltd
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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United States
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Changzhou Hopschain Chemical Co.,Ltd.
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Amadis Chemical Company Limited
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571-89925085
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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550-70-9, TRIPROLIDINE HYDROCHLORIDERelated Search:


  • TRANS-2[3-(1-PYRROLIDINYL)-1-P-TOLYLPROPENYL]PYRIDINE HYDROCHLORIDE
  • TRIPROLIDINE HCL
  • TRANS-TRIPROLIDINE HYDROCHLORIDE
  • (E)-2-[1-(4-METHYLPHENYL)-3-(1-PYRROLIDINYL)-1-PROPENYL]PYRIDINE HYDROCHLORIDE
  • triprolidine hydrochloride (anh.)
  • (E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine hydrochloride
  • 2-[(1E)-1-(4-Methylphenyl)-3-pyrrolizino-1-propenyl]pyridine·hydrochloride
  • Venen
  • 295 C 51
  • Actidil
  • Actidilat
  • Einecs 208-985-0
  • Entra
  • Pro-actidil
  • Pro-entra
  • Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl)-, hydrochloride (1:1)
  • 2-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]pyridine Hydrochloride
  • Actidilon
  • trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene Hydrochloride
  • Triprolidine hydrochlorideQ: What is Triprolidine hydrochloride Q: What is the CAS Number of Triprolidine hydrochloride Q: What is the storage condition of Triprolidine hydrochloride Q: What are the applications of Triprolidine hydrochloride
  • Triprolidine hydrochloride anhydrous
  • 550-70-9
  • 570-70-9
  • C19H22N2HCl
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals