Triprolidine hydrochloride
- Product Name
- Triprolidine hydrochloride
- CAS No.
- 6138-79-0
- Chemical Name
- Triprolidine hydrochloride
- Synonyms
- rate,stereoisomer;TRIPROLIDINE HCL USP;trans-TriprolidineHCl;Tripolidine Hydrochloride;Triprolidine hydrochloride;Triprolidine Hydrochlorise;TRIPROLIDINE HCL MONOHYDRATE;TRIPROLIDINEHYDROCHLORIDE,USP;Triprolidine hydrochloride (347);triprolidinesigmareferencestandard
- CBNumber
- CB6232533
- Molecular Formula
- C19H23ClN2
- Formula Weight
- 314.85
- MOL File
- 6138-79-0.mol
Triprolidine hydrochloride Property
- Melting point:
- 115-120°C
- storage temp.
- 2-8°C
- solubility
- alcohol: soluble1 in 1.5 of solvent
- color
- White to Off-White
- Water Solubility
- >=10 g/100 mL at 20 ºC
- Merck
- 13,9817
- Stability:
- Stable, but discolours in light. Incompatible with strong oxidizing agents.
- LogP
- 4.223 (est)
- CAS DataBase Reference
- 6138-79-0(CAS DataBase Reference)
- EPA Substance Registry System
- Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)- (6138-79-0)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- UT7658000
- HS Code
- 2933399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T6764
- Product name
- Triprolidine hydrochloride
- Purity
- ≥99%
- Packaging
- 1g
- Price
- $45.5
- Updated
- 2024/03/01
- Product number
- PHR2662
- Product name
- Triprolidine
- Purity
- PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
- Packaging
- 500MG
- Price
- $200
- Updated
- 2024/03/01
- Product number
- 1696007
- Product name
- Triprolidine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 300mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- BP347
- Product name
- Triprolidine hydrochloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $263
- Updated
- 2023/01/07
- Product number
- T-140
- Product name
- Triprolidine hydrochloride solution
- Purity
- 1?mg/mL in methanol ((as free base)), certified reference material, ampule of 1?mL, Cerilliant?
- Packaging
- 1ML
- Price
- $88.7
- Updated
- 2022/05/15
Triprolidine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.
Uses
anticholinergic (opthalmic)
Uses
trans-Triprolidine Hydrochloride is a potent H1 receptor antagonist. Anti-histamines.
Uses
TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet
Definition
TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.
brand name
Actidil (GlaxoSmithKline); Myidyl (USl).
General Description
Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.
The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.
General Description
Odorless white crystalline powder. Bitter taste.
Air & Water Reactions
Water soluble.
Reactivity Profile
Triprolidine hydrochloride discolors on exposure to light.
Health Hazard
SYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.
Fire Hazard
Flash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.
Biological Activity
Potent H 1 receptor antagonist.
Triprolidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Triprolidine hydrochloride Suppliers
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View Lastest Price from Triprolidine hydrochloride manufacturers
- Product
- Triprolidine hydrochloride 6138-79-0
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Triprolidine hydrochloride 6138-79-0
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%-101%
- Supply Ability
- 100KG
- Release date
- 2021-05-28
- Product
- Triprolidine hydrochloride 6138-79-0
- Price
- US $0.00/KG Ton
- Min. Order
- 1KG Ton
- Purity
- USP4398%+
- Supply Ability
- 2 tons/month
- Release date
- 2022-10-09