ChemicalBook > CAS DataBase List > Triprolidine hydrochloride

Triprolidine hydrochloride

Product Name: Triprolidine hydrochloride
CAS No.: 6138-79-0
Chemical Name: Triprolidine hydrochloride
Synonyms: rate,stereoisomer;TRIPROLIDINE HCL USP;trans-TriprolidineHCl;Tripolidine Hydrochloride;Triprolidine hydrochloride;Triprolidine Hydrochlorise;TRIPROLIDINE HCL MONOHYDRATE;TRIPROLIDINEHYDROCHLORIDE,USP;Triprolidine hydrochloride (347);triprolidinesigmareferencestandard
CBNumber: CB6232533
Molecular Formula: C19H23ClN2
Formula Weight: 314.85
MOL File: 6138-79-0.mol

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Triprolidine hydrochloride Property

Melting point:: 115-120°C
storage temp.: 2-8°C
solubility: alcohol: soluble1 in 1.5 of solvent
form: Solid
color: White to Off-White
Water Solubility: >=10 g/100 mL at 20 ºC
Merck: 13,9817
Stability:: Stable, but discolours in light. Incompatible with strong oxidizing agents.
InChI: InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
InChIKey: WYUYEJNGHIOFOC-NWBUNABESA-N
SMILES: C(=C/CN1CCCC1)(\C1=NC=CC=C1)/C1C=CC(C)=CC=1.Cl
LogP: 4.223 (est)
CAS DataBase Reference: 6138-79-0(CAS DataBase Reference)
EPA Substance Registry System: Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)- (6138-79-0)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: UT7658000
HS Code: 2933399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T6764
Product name: Triprolidine hydrochloride
Purity: ≥99%
Packaging: 1g
Price: $46.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR2662
Product name: Triprolidine
Purity: PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
Packaging: 500MG
Price: $205.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: BP347
Product name: Triprolidine hydrochloride
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $272
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1696007
Product name: Triprolidine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 300mg
Price: $413
Updated: 2025/07/31

Sigma-Aldrich

Product number: T-140
Product name: Triprolidine hydrochloride solution
Purity: 1?mg/mL in methanol ((as free base)), certified reference material, ampule of 1?mL, Cerilliant?
Packaging: 1ML
Price: $88.7
Updated: 2022/05/15

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Triprolidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.

Uses

anticholinergic (opthalmic)

Uses

trans-Triprolidine Hydrochloride is a potent H1 receptor antagonist. Anti-histamines.

Uses

TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

Definition

TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.

brand name

Actidil (GlaxoSmithKline); Myidyl (USl).

General Description

Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.
The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.

General Description

Odorless white crystalline powder. Bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

Triprolidine hydrochloride discolors on exposure to light.

Health Hazard

SYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.

Fire Hazard

Flash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.

Biological Activity

Potent H 1 receptor antagonist.

Triprolidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Triprolidine hydrochloride manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Triprolidine hydrochloride 6138-79-0
Price: US $100.00/G
Min. Order: 10G
Purity: ＞99%
Supply Ability: 1KG
Release date: 2025-07-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Triprolidine hydrochloride 6138-79-0
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%-101%
Supply Ability: 100KG
Release date: 2021-05-28

Shaanxi Dideu New Materials Co. Ltd

Product: Triprolidine hydrochloride 6138-79-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-08

6138-79-0, Triprolidine hydrochlorideRelated Search:

Topotecan hydrochloride 1-Hexadecylpyridinium bromide Triprolidine Pyridine Cetylpyridinium chloride monohydrate Polyvinylpyrrolidone Pyridine hydrochloride Cyproheptadine hydrochloride sesquihydrate Povidone iodine N-Methyl-2-pyrrolidone CALAMINE ALPHA,P-DIMETHYLSTYRENE TRANS-TRIPROLIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE METHYL-2-PYRROLIDONE TRIPOLIDINE Triprolidine hydrochloride TRIPROLIDINE HYDROCHLORIDE Z-ISOMER (100 MG)

Triprolidine Hydrochloride (500 mg)

Triprolidine Hydrochloride (300 mg)

TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE

pyridine,2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-,monohydrochloride,monohyd

Pyridine,2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]-,monohydrochloride,monohydrate,stereoisomer

rate,stereoisomer

triprolidinesigmareferencestandard

Pyridine, 2-(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl-, monohydrochloride, monohydrate

TRIPROLIDINEHYDROCHLORIDE,USP

2-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine hydrochloride monohydrate

Tripolidine Hydrochloride

TRIPROLIDINE HCL USP

TRIPROLIDINE HCL MONOHYDRATE

trans-TriprolidineHCl

(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride

trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene hydrochloride monohydrate

trans-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride monohydrate

(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride

2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine monohydrochloride

Triprolidine hydrochloride

2-[(E)-1-(4-Methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrate hydrochloride

2-[1-(4-Methylphenyl)-3-(2,3,4,5-tetrahydropyrrol-1-yl)prop-1-enyl]pyridine chloride hydrate

Triprolidine hydrochloride,(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride

Triprolidine Hydrochlorise

2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop1-en-1-yl]pyridine hydrate hydrochloride

Triprolidine hydrochloride USP/EP/BP

(E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine hydrochloride hydrate

Triprolidine hydrochloride (347)

Triprolidine Hydrochloride (1696007)

Triprolidine hydrochloride monohydrate, 10 mM in DMSO

Triprolidine hydrochloride solution

6138-79-0

C19H22N2ClHH2O

C19H23N2ClH2O

C19H22N2HClH2O

MYRDRIACYL

Bulk Pharmaceuticals