ChemicalBook > CAS DataBase List > Tulathromycin A

Tulathromycin A

Product Name
Tulathromycin A
CAS No.
217500-96-4
Chemical Name
Tulathromycin A
Synonyms
CS-2009;Draxxin;CP 472295;Teramycin;Tulamycin;Tulathrmycin A;TULATHROMYCIN A;Unii-897A3kn7ap;Tulathromycin A, >=95%;Tulathromycin isomer mix
CBNumber
CB41011760
Molecular Formula
C41H79N3O12
Formula Weight
806.09
MOL File
217500-96-4.mol
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Tulathromycin A Property

Melting point:
186-188oC
Boiling point:
853.8±65.0 °C(Predicted)
Density 
1.17
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.19±0.70(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2107
Product name
Tulathromycin A
Purity
≥95% (HPLC)
Packaging
10MG
Price
$91.6
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2107
Product name
Tulathromycin A
Purity
≥95% (HPLC)
Packaging
50MG
Price
$371
Updated
2024/03/01
Cayman Chemical
Product number
19202
Product name
Tulathromycin A
Purity
≥95%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
19202
Product name
Tulathromycin A
Purity
≥95%
Packaging
10mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
19202
Product name
Tulathromycin A
Purity
≥95%
Packaging
25mg
Price
$208
Updated
2024/03/01
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Tulathromycin A Chemical Properties,Usage,Production

Description

Tulathromycin A, marketed as Draxxin by Pfizer Inc., is a triamide antibiotic used for the treatment of respiratory diseases in cattle and pigs. It exists as a balanced mixture of two isomers, Tulathromycin A (90%) and B (10%). Tulathromycin is an antimicrobial agent of a macrolide, a 15-membered macrolide structure that is considered a triamide macrolide with three charged nitro groups.

Chemical Properties

Tulathromycin is a semi-synthetic macrolide antibiotic of the sub-class triamilide. It occurs as a white to off-white crystalline powder that is readily soluble in water at pH less than 8. At a pH of 7.4 (physiological pH), tulathromycin (a weak base) is 50 times more soluble in hydrophilic than hydrophobic media.

Uses

Tulathromycin A is used for the treatment of pulmonary diseases in pigs and cattle.
In cattle, tulathromycin is used for the treatment of rinderpest caused by Haemolytic rinderpest, polyvalent rinderpest and Haemophilus somnus (formerly Haemophilus somnus). It is also effective in the treatment of infections caused by Mycoplasma bovis. When used in high-risk calves, it is also used to prevent infections caused by these pathogens. It is also used for the treatment of bovine foot rot (interdigital necrotizing fungal disease) associated with Fusarium necrophorum and Fusarium oxysporum. A single dose is effective in bovine infectious keratoconjunctivitis (Mycobacterium bovis).
In pigs, it is used to control and treat SRD associated with Actinobacillus pleuropneumoniae, Bacteroides multilocularis, Bordetella bronchiseptica, Mycoplasma pneumoniae, and Haemophilus parasiticus, and tulathromycin has been used to treat lung abscesses.

Definition

ChEBI:Tulathromycin A is an aminoglycoside.

Biological Activity

Tulathromycin, like other macrolides, exerts therapeutic benefits not solely explainable by antibacterial activity. Like azithromycin, tulathromycin A may have multiple immunomodulatory effects that likely contribute to the therapeutic response in respiratory infections and perhaps other diseases[1]. Other beneficial effects may be caused by enhanced degranulation and apoptosis of neutrophils and inhibition of inflammatory cytokine production. It also may help clear infections by enhancing macrophage functions.

Pharmacokinetics

The half-life is long, with 80- to 90-hour plasma half-life in pigs and cattle, and 8- and 6-day tissue half-life in cattle and pigs, respectively, which prolongs the drug concentration at the site of infection. The volume of distribution is greater than 10 L/kg. Absorption from injection is greater than 80% in cattle and pigs. Tulathromycin A concentrates in bronchoalveolar cells, and concentrations are detectable for at least 8 days after a single administration, although they are still lower than the MIC for R. equi (greater than 64 μg/mL)[1-2].

Mode of action

Tulathromycin A is a macrolide antibiotic. It binds to the subunit 50S of the bacterial ribosome, interfering with bacterial protein synthesis.

References

[1] Mark G, et al. Tulathromycin. Papich Handbook of Veterinary Drugs (Fifth Edition), 2021; 949-951.
[2] Jennifer L, et al. Pharmacologic Principles. Equine Internal Medicine (Fourth Edition), 2018; 79-137.

Tulathromycin A Preparation Products And Raw materials

Raw materials

Preparation Products

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Tulathromycin A Suppliers

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View Lastest Price from Tulathromycin A manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Tulathromycin 217500-96-4
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-12-05
Sinoway Industrial co., ltd.
Product
Tulathromycin 217500-96-4
Price
US $0.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
95% up, Vet-GMP
Supply Ability
20tons
Release date
2024-06-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tulathromycin A 217500-96-4
Price
US $0.00-0.00/KG
Min. Order
10g
Purity
96%-102%
Supply Ability
50KG
Release date
2021-05-28

217500-96-4, Tulathromycin ARelated Search:

Diclazuril TULATHROMYCIN B,Tulathromycin Bensulfuron methyl Thiophanate-methyl Methylparaben METSULFURON METHYL Azithromycin Methyl acetate Gentamicin Clindamycin Methyl acrylate Kresoxim-methyl Telithromycin Tiamulin Tylosin Tiamulin fumarate Methyl [2H9]-Tulobuterol, racemic mixture

  • TULATHROMYCIN A
  • (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-a-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
  • Unii-897A3kn7ap
  • (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-Methyl-3-O-Methyl-4-C-[(propylaMino)Methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexaMethyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
  • CP 472295
  • Draxxin
  • Tulathromycin A, >=95%
  • Tulathrmycin A
  • Tulathromycin A Solution, 1000ppm
  • Tulathromycin，Tulathromycin A
  • CS-2009
  • (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
  • Tulathromycin isomer mix
  • pharmaceutical ingredient TULATHROMYCIN A
  • 1-Oxa-6-azacyclopentadecan-15-one, 13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
  • Tulathromycin A USP/EP/BP
  • Tulathromycin A (CP 472295)
  • (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-((propylamino)methyl)tetrahydro-2H-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
  • Teramycin
  • Tulamycin
  • Tulathromycin isomer mix in acetonitrile
  • 217500-96-4
  • C41H79N3O12
  • API
  • Carbohydrates & Derivatives
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 217500-96-4