ChemicalBook > CAS DataBase List > Gamma-mangostin

Gamma-mangostin

Background

Product Name: Gamma-mangostin
CAS No.: 31271-07-5
Chemical Name: Gamma-mangostin
Synonyms: Nomangostin;r-Mangostin;γ-Mangostin;Normangostin;γ- Mangostin;Mangostin, γ-;γ-Mangostin-RM;Gamma-mangostin;Gamma-mangostin γ-Mangostin;gamma-Mangostin >=98% (HPLC)
CBNumber: CB41040702
Molecular Formula: C23H24O6
Formula Weight: 396.43
MOL File: 31271-07-5.mol

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Gamma-mangostin Property

Melting point:: 206-208 °C
Boiling point:: 648.4±55.0 °C(Predicted)
Density: 1.326±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: methanol: soluble1mg/mL, colorless to yellow
form: powder
pka: 7.05±0.20(Predicted)
color: off-white to yellow
InChI: InChI=1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3
InChIKey: VEZXFTKZUMARDU-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=C(O)C(O)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(O)=C2
LogP: 5.744 (est)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: ZD6122330

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL80496
Product name: gamma-Mangostin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $546
Updated: 2025/07/31

Sigma-Aldrich

Product number: M6824
Product name: gamma-Mangostin
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $569
Updated: 2025/07/31

Sigma-Aldrich

Product number: M6824
Product name: gamma-Mangostin
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $1780
Updated: 2025/07/31

Cayman Chemical

Product number: 26675
Product name: γ-Mangostin
Packaging: 5mg
Price: $123
Updated: 2024/03/01

Cayman Chemical

Product number: 26675
Product name: γ-Mangostin
Packaging: 50mg
Price: $918
Updated: 2024/03/01

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Gamma-mangostin Chemical Properties,Usage,Production

Background

Garcinia mangostana L., commonly known as mangosteen, is a tree mainly found in India, Myanmar, Sri Lanka and Thailand. The pericarp of mangosteen has been used in Thailand as an indigenous medicine for treating skin infections, wounds and diarrhea. The major bioactive compounds in mangosteen are xanthone derivatives, with α-mangostin (1, α-M) and Gamma-mangostin (4, γ-M) being the main derivatives isolated. α-M and γ-M possess not only antioxidant activity but also a wide range of biological activities, such as tumour cell-selective apoptosis and the attenuation of amyloid-β neurotoxicity and anti-inflammation. Gamma-mangostin strongly inhibited human colorectal adenocarcinoma cell proliferation. It was shown that γ-mangostin may mediate cytotoxicity via apoptosis in HT29 cells. Hence, it is a strong lead compound candidate in treating colon cancer cell growth and may directly affect colorectal adenocarcinoma cancer susceptibility through its modulation of cell proliferation and apoptosis[1].

Chemical Properties

It is soluble in organic solvents such as methanol, ethanol, and DMSO, and is derived from mangosteen shell.

Uses

Gamma-Mangostin is a xanthones which displays anti-oxidant properties and could be a promising compound for the therapy of AlzheimerтАЩs disease.

Definition

ChEBI: A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense /ital>, it exhibits antitumour activity.

Biological Activity

Xanthone derivative isolated from the mangosteen hull (Garcinia mangostana). Exhibits antioxidant and anticancer properties. Mangosteen xanthones inhibit inflammation in human adipocytes which is important in understanding obesity-associated inflammation and the development of insulin resistance.

in vivo

Gamma-Mangostin (0.5, 1, 2 mg/kg; Oral gavage (p.o.); 14 days) significantly reduces fasting blood glucose, cholesterol, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and ameliorates damaged hepatocytes, primarily swelling, hydropic changes, and necrotic cells in the streptozotocin (STZ) (HY-13753) (30 mg/kg) induced diabetic BALB/C mouse model^[3].
Gamma-Mangostin (1, 2, 4 mg/kg; Oral gavage (p.o.); 14 days) significantly reduces blood urea nitrogen (BUN) and creatinine in plasma, and ameliorates the damage to renal proximal tubular cells in BALB/C mice with streptozotocin (STZ) (HY-13753) (30 mg/kg) induced diabetes^[4].
Gamma-Mangostin (0.1, 0.2, 0.4 mg; Oral gavage (p.o.); 4 weeks) can reduce fasting blood glucose levels and oral glucose tolerance tests in diabetic ICR mice^[5].

Animal Model:	STZ (HY-13753) (30 mg/kg)-induced BALB/C diabetic mouse model^[3]
Dosage:	0.5 mg/kg, 1 mg/kg, 2 mg/kg
Administration:	Oral gavage (p.o.); 14 days
Result:	Significantly reduced fasting blood glucose, cholesterol, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamate-pyruvate transaminase (SGPT) in diabetic mice. Improved damaged liver cells, primarily those exhibiting swelling, water accumulation, and cell necrosis.

IC 50

5-HT_2A Receptor; COX-2

References

[1] Takeshi Yokoyama. “Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor.” Scientific Reports (2015): 13570.

Gamma-mangostin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Gamma-mangostin manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Gamma-mangostin 31271-07-5
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

Shaanxi Dideu Medichem Co. Ltd

Product: Gamma-mangostin 31271-07-5
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-07-14

Shanghai Standard Technology Co., Ltd.

Product: Gamma-mangostin 31271-07-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-27

31271-07-5, Gamma-mangostinRelated Search:

Garciniaxanthone E Garcinexanthone A Beta-mangostin 4,4'-Dihydroxybenzophenone 2,3',4,4'-TETRAHYDROXYBENZOPHENONE 2-HYDROXY-5-METHYLBENZOPHENONE Mangostin 2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE 2,4,4'-TRIHYDROXYBENZOPHENONE 2,3',4,4',6-Pentahydroxybenzophenone Gamma-mangostin 2,2',4,4'-Tetrahydroxybenzophenone GENTISEIN 1,3-dihydroxyxanthone PHLOROBENZOPHENONE 3,6-Dimethoxyxanthone 1-Phenoxy-4-(2-propenyl)benzene 1-(2-ALLYL-3,6-DIHYDROXYPHENYL)ETHAN-1-ONE

Gamma-mangostin

1,3,6,7-Tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one

Normangostin

r-Mangostin

1,3,6,7-Tetrahydroxy-2,8-bis(3-Methylbut-2-en-1-yl)-9H-xanthen-9-one

1,3,6,7-Tetrahydroxy-2,8-bis(3,3-dimethylallyl)xanthone

gamma-Mangostin (r-Mangostin)

Nomangostin

9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-

Gamma-mangostin γ-Mangostin

gamma-Mangostin >=98% (HPLC)

1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one

γ- Mangostin

γ-Mangostin-RM

gamma-Mangostin, 10 mM in DMSO

γ-Mangostin

Mangostin, γ-

31271-07-5