ChemicalBook > CAS DataBase List > Levothyroxine sodium

Levothyroxine sodium

Product Name
Levothyroxine sodium
CAS No.
55-03-8
Chemical Name
Levothyroxine sodium
Synonyms
L-THYROXINE SODIUM PENTAHYDRATE;L-THYROXINE SODIUM SALT PENTAHYDRATE;L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodiumsalt;LT4 sodium;L-T4 sodium;Levothyroxine Sdium;Levothyroxine sodium;Thyroxine Soduim Salt;Levothyroxine sodium ,T4;L-ThyroxineSodiumSaltB.P.
CBNumber
CB4106276
Molecular Formula
C15H12I4NNaO4
Formula Weight
800.87
MOL File
55-03-8.mol
More
Less

Levothyroxine sodium Property

Melting point:
207-210 (dec.)(lit.)
alpha 
D20 -4.4° (c = 3 in 70% ethanol)
Density 
d420 2.381
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
cell culture medium: 0.1 mg/mL
form 
powder
BCS Class
1,3
Stability:
Hygroscopic
InChIKey
JMHCCAYJTTWMCX-QWPJCUCISA-M
EPA Substance Registry System
Levothyroxine sodium (55-03-8)
More
Less

Safety

Safety Statements 
22-24/25
RIDADR 
2811
WGK Germany 
3
RTECS 
YP2833760
F 
3-8-10
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2937909000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
T0245
Product name
L-Thyroxine Sodium Salt Pentahydrate
Purity
>98.0%(T)
Packaging
1g
Price
$40
Updated
2021/12/16
TCI Chemical
Product number
T0245
Product name
L-Thyroxine Sodium Salt Pentahydrate
Purity
>98.0%(T)
Packaging
100mg
Price
$14
Updated
2021/12/16
TRC
Product number
T425601
Product name
ThyroxineSodiumSalt
Packaging
10g
Price
$275
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
53167
Product name
ThyroxineSodiumSalt
Packaging
1g
Price
$610
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007805
Product name
LEVOTHYROXINE SODIUM
Purity
95.00%
Packaging
1G
Price
$704.55
Updated
2021/12/16
More
Less

Levothyroxine sodium Chemical Properties,Usage,Production

Chemical Properties

Levothyroxine sodium is White Solid

Originator

Synthroid,Flint,US,1953

Uses

One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.

Definition

ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.

Indications

Levothyroxine sodium (Levothroid, Synthroid, Levoxine) is the sodium salt of the naturally occurring levorotatory isomer of T4. It is the preparation of choice for maintenance of plasma T4 and T3 concentrations for thyroid hormone replacement therapy in hypothyroid patients. It is absorbed intact from the gastrointestinal tract, and its long half-life allows for convenient oncedaily administration. Since much of the T4 is deiodinated to T3, it is usually unnecessary to use more expensive preparations containing both T4 and T3.The aim is to establish euthyroidism with measured serum concentrations of T4, T3, and TSH within the normal range.
The TSH-suppressive effects of exogenous T4 also prove useful in removing the stimulatory effects of TSH on the thyroid gland in the management of simple nonendemic goiter, chronic thyroiditis, and TSHdependent thyroid carcinoma.

Manufacturing Process

A 9.30 g portion of N-acetyl-L-diiodotyrosinamide was suspended in 100 ml of 0.05M boric acid (H3BO3) and 100 ml of 95% ethanol, and the solid was dissolved by adjusting the pH to 10.5 with 2N sodium hydroxide (NaOH). A 15% (by weight) portion of manganese sulfate monohydrate was added and the solution heated at 44°C under conditions of oxygenation while being agitated mechanically. After approximately 24 hours of incubation, the precipitated product was collected and separated from the catalyst, providing the amide of N-acetyl-L-thyroxine in 30.6% yield. On hydrolysis (removal of both amide functions), achieved by refluxing in glacial acetic acid-hydrochloric acid (approximately 2:1), L-thyroxine is obtained. It was isolated as the sodium salt, containing approximately 5 molecules of water of hydration.

brand name

Levo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).

Therapeutic Function

Thyroid hormone

General Description

Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.

Clinical Use

Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.

Veterinary Drugs and Treatments

Levothyroxine sodium is indicated for the treatment of hypothyroidism in all species.

Levothyroxine sodium Preparation Products And Raw materials

Raw materials

L-Thyroxine Acetic acid Sodium levothyroxine

Preparation Products

More
Less

Levothyroxine sodium Suppliers

Austria 1 Belgium 1 Brazil 1 Canada 3 China 161 Czech Republic 1 Europe 2 France 2 Germany 9 India 37 Italy 3 Japan 2 Malaysia 1 Nepal 1 Slovakia 1 Slovenia 1 Switzerland 1 United Kingdom 7 United States 31 Venezuela 1 Global 267
Shifang ShengYuan Technology Co., Ltd.
Tel
0838-6510595 18881099744 18881099744
Email
1120021438@qq.com
Country
China
ProdList
153
Advantage
56
Suzhou Pharmaceutical Technology co.,ltd
Tel
051088771160，18051901298 19952779122
Fax
0510-8877116
Email
2013446823@qq.com
Country
China
ProdList
52
Advantage
61
Shanghai Mokai Pharmaceutical Technology Co., Ltd.
Tel
021-60951261 18601606476
Email
nancy@mkpharma.cn
Country
China
ProdList
453
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
0512-68780025,68780026 18962125825
Email
sales@ryanchem.com
Country
China
ProdList
161
Advantage
62
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
Suzhou Ryan Pharmachem Technology Co.,Ltd
Tel
0512-66585217 13962137180
Fax
0512-82177549
Email
sales@ryanchem.com
Country
China
ProdList
390
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4928
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9664
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5877
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
10015
Advantage
53
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Changsha Jing Kang New Material Technology Co., Ltd.
Tel
0731-85118349 18874718518
Fax
0731-85118349
Email
ma_haihong@sina.com
Country
China
ProdList
1597
Advantage
50
Watson Biotechnology Co.,Ltd
Tel
027-027-59207879 18140587686
Fax
QQ：1972026995
Email
kf@3600chem.com
Country
China
ProdList
4699
Advantage
55
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4515
Advantage
55
Hangzhou Dingyan Chem Co., LTD
Tel
0571-0571-87157530-8001-8003 18008611859
Fax
0571-87156470
Email
sales@dingyanchem.com
Country
China
ProdList
1997
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27322
Advantage
60
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
1649
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9980
Advantage
55
klamar reagent
Tel
4001650900
Fax
021-64897811
Email
sales-wang@klamar-reagent.com
Country
China
ProdList
1986
Advantage
55
Wuhan HongxinKang Fine Chemical Co., Ltd.
Tel
027-59362599 18674037007
Fax
027-84802889
Email
zhuoxingwc@163.com
Country
China
ProdList
950
Advantage
58
Chengdu Youngshe Chemical Co., Ltd.
Tel
028-62328193 17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
2348
Advantage
58
Shanghai Mokay Pharmaceutical Technology Co., Ltd.
Tel
021-60257269 18601606476
Fax
+86-21-60253672
Email
yl@mkpharma.cn
Country
China
ProdList
206
Advantage
58
Capot Chemical Co.,Ltd.
Tel
571-85586718 +8613336195806
Fax
+86-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
29797
Advantage
60
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15396
Advantage
58
Conier Chem & Pharma Limited
Tel
13368167990
Email
sales@conier.com
Country
China
ProdList
2809
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15503
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6037 18920794737
Email
sales@heowns.com
Country
China
ProdList
20506
Advantage
60
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10305
Advantage
58
GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD
Tel
020-37651955 13682223272
Fax
020-87659730
Email
173901442@qq.com
Country
China
ProdList
695
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52712
Advantage
58
More
Less

View Lastest Price from Levothyroxine sodium manufacturers

Hebei Lingding Biotechnology Co., Ltd.
Product
Levothyroxine sodium 55-03-8
Price
US $80.00-71.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2024-03-28
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Levothyroxine sodium 55-03-8
Price
US $0.00/Kg/Bag
Min. Order
100g
Purity
97%-103% HPLC
Supply Ability
10KGS
Release date
2021-07-20
Baoji Guokang Bio-Technology Co., Ltd.
Product
Levothyroxine sodium 55-03-8
Price
US $3095.00/Kg/Bag
Min. Order
1KG
Purity
99
Supply Ability
1T
Release date
2021-06-04

55-03-8, Levothyroxine sodium Related Search:

Sodium bicarbonate Sodium benzoate Inositol DL-THYROXINE L-Tyrosine Sodium acetate REVERSE T3 Sodium citrate L-Thyroxine Sodium alginate CHLOROPHOSPHONAZO III Diclofenac sodium Sodium hydroxide TSH Trisodium phosphate (1R)-(-)-10-Camphorsulfonic acid (R)-(-)-Epichlorohydrin 6-(Difluoromethoxy)-2-[(S)-[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt

  • Levothyroxine sodium
  • Sodium 4-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
  • (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid odium
  • (s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic acid sodium salt
  • sodium (s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate
  • L-THYROXINE SODIUM ANHYDROUS
  • Levothyroxine Sdium
  • levothyroxine sodium anhydrous
  • LT4 sodium
  • L-T4 sodium
  • (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid Sodium Salt Sodium (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate
  • sodiuM (S)-2-aMino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
  • L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodiuM salt (1:1)
  • SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE PENTAHYDRATE
  • (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT PENTAHYDRATE
  • <small>L</small>-Thyroxine Sodium Salt Pentahydrate
  • 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE SODIUM SALT PENTAHYDRATE
  • 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE PENTAHYDRATE
  • Levothyroxine sodium ,T4
  • L-THYROXINE SODIUM SALT PENTAHYDRATE
  • L-THYROXINE SODIUM PENTAHYDRATE
  • 3-Amino-4-(4-(4-OH-3,5-diiodophenoxy)-3,5-diiodophenyl))but.ac.Na salt
  • L-ThyroxineSodiumSaltB.P.
  • L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodiumsalt
  • Levothyroxine sodium USP/EP/BP
  • levothyroxine sodium anhydrousdium anhydrous
  • Levothyroxine SodiumQ: What is Levothyroxine Sodium Q: What is the CAS Number of Levothyroxine Sodium Q: What is the storage condition of Levothyroxine Sodium Q: What are the applications of Levothyroxine Sodium
  • (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid Sodium Salt Pentahydrate
  • Thyroxine Soduim Salt
  • 55-03-8
  • 55-03-86106-07-6
  • C15H11I4NNaO4
  • C15H10I4NNaO45H2O
  • C15H10I4NO4Na
  • Other Protein/Peptide Hormones
  • Hormones
  • Thyroxine (T4)
  • Cytokines, Growth Factors and Hormones
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Amino Acids & Derivatives
  • Aromatics
  • Amino Acids
  • Biochemistry
  • Biological-modified Amino Acids
  • Medicine intermediate
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroid and Hormone
  • 55-03-8