3-CHLORO-1-PHENYL-1-PROPANOL

Product Name: 3-CHLORO-1-PHENYL-1-PROPANOL
CAS No.: 18776-12-0
Chemical Name: 3-CHLORO-1-PHENYL-1-PROPANOL
Synonyms: Fluoxetine impurity 5;3-CHLORO-1-PHENYLPROPANOL;rac 3-Chloro-1-phenylpropanol;α-(2-Chloroethyl)benzenemethanol;3-Chloro-1-phenyl-1-propanol >BenzeneMethanol, α-(2-chloroethyl)-;3-Chloro-1-phenylpropan-1-ol , 3-Chloro-1-phenyl-propanol
CBNumber: CB41090893
Molecular Formula: C9H11ClO
Formula Weight: 170.64
MOL File: 18776-12-0.mol

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3-CHLORO-1-PHENYL-1-PROPANOL Property

Melting point:: 31.0 to 36.0 °C
Boiling point:: 116°C/4mmHg(lit.)
Density: 1.1344 g/cm3
refractive index: 1.54
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 13.92±0.20(Predicted)
color: White to Off-White
InChIKey: JZFUHAGLMZWKTF-UHFFFAOYSA-N

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Safety

HS Code: 2906.29.6000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2904
Product name: 3-Chloro-1-phenyl-1-propanol
Purity: >98.0%(GC)
Packaging: 5g
Price: $112
Updated: 2025/07/31

TCI Chemical

Product number: C2904
Product name: 3-Chloro-1-phenyl-1-propanol
Purity: >98.0%(GC)
Packaging: 25g
Price: $391
Updated: 2025/07/31

Usbiological

Product number: 288653
Product name: rac 3-chloro-1-phenylpropanol
Packaging: 25mg
Price: $446
Updated: 2021/12/16

TRC

Product number: C379650
Product name: rac3-Chloro-1-phenylpropanol
Packaging: 250mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-W019837
Product name: α-(2-Chloroethyl)benzenemethanol
Purity: 99.60%
Packaging: 500g
Price: $655
Updated: 2021/12/16

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3-CHLORO-1-PHENYL-1-PROPANOL Chemical Properties,Usage,Production

Uses

An intermediate of racemic Atomoxetine.

Synthesis

936-59-4

18776-12-0

General procedure for the synthesis of 3-chloro-1-phenylpropan-1-one from 3-chloropropiophenone: 3-chloro-1-phenylpropan-1-one (7.80 g, 46.26 mmol) was dissolved in a solvent mixture of THF (35 mL) and EtOH (35 mL) at -10 °C and protected by nitrogen with stirring. Sodium borohydride (2.20 g, 48.83 mmol) was added in batches over 10 min. The reaction mixture was continued to be stirred at -5 °C for 10 min, followed by slow pouring into a stirring mixture of saturated aqueous ammonium chloride solution (85 mL) and ice (40 g). The mixture was extracted twice with ether, the organic phases were combined, dried and the solvent was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, gradient from 100/0 to 95/5) to give 3-chloro-1-phenylpropanol (7.50 g, 95% yield) as a pale yellow oil. Nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3) δ: 7.39 (d, 5H), 4.91-5.01 (m, 1H), 3.70-3.83 (m, 1H), 3.59 (s, 1H), 2.20-2.32 (m, 1H), 2.11 (d, 1H).

References

[1] Pharmaceutical Research, 2017, vol. 34, # 12, p. 2873 - 2890
[2] Biological and Pharmaceutical Bulletin, 2011, vol. 34, # 4, p. 538 - 544
[3] Patent: WO2016/67043, 2016, A1. Location in patent: Page/Page column 325
[4] Organic Process Research and Development, 2000, vol. 4, # 6, p. 513 - 519
[5] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 11, p. 1767 - 1769

3-CHLORO-1-PHENYL-1-PROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-1-PHENYL-1-PROPANOL Suppliers

Americas 1 Belgium 1 Canada 2 China 133 Europe 1 France 3 Germany 4 India 20 Japan 2 Switzerland 1 United Kingdom 3 United States 23 Global 194

J & K SCIENTIFIC LTD.

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View Lastest Price from 3-CHLORO-1-PHENYL-1-PROPANOL manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Chloro-1-phenylpropanol 18776-12-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Chloro-1-phenylpropanol 18776-12-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: 3-CHLORO-1-PHENYL-1-PROPANOL 18776-12-0
Price: US $1.80-3.60/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 88KG
Release date: 2019-09-04

18776-12-0, 3-CHLORO-1-PHENYL-1-PROPANOLRelated Search:

Dapoxetine (S)-3-PHENYL-BETA-ALANINOL HCL (S)-3-Dimethylamino-3-phenylpropanol 3-AMINO-3-PHENYL-1-PROPANOL (S)-3-Amino-3-phenylpropan-1-ol (1R)-3-Chloro-1-phenyl-propan-1-ol (S)-3-Chloro-1-phenyl-1-propanol Z-3-Chloro-1-(2-chlorophenyl)-2-(4-fluorophenyl)-oxirane TRIDIPHANE (R)-3-CHLORO-1-(3,4-DICHLORO-PHENYL)-PROPAN-1-OL 3-CHLORO-1-PHENYL-1-PROPANOL (S)-3-CHLORO-1-(3,4-DICHLORO-PHENYL)-PROPAN-1-OL (S)-3-CHLORO-1-PHENYL-1-[2-METHYL-PHENOXYL]PROPANE 1,1-DICHLORO-1A-(4-ETHOXYPHENYL)-7-O-TOLYL-1,1A,7,7A-TETRAHYDROCYCLOPROPA[B]CHROMENE AURORA KA-4840 (R)-3-CHLORO-1-PHENYL-1-[2-METHYL-PHENOXYL]PROPANE 1-chloro-4-(3-chloro-1-methoxypropyl)benzene 1,1-DICHLORO-1A-(4-ETHOXYPHENYL)-7-PHENYL-1,1A,7,7A-TETRAHYDROCYCLOPROPA[B]CHROMENE

3-CHLORO-1-PHENYLPROPANOL

rac 3-Chloro-1-phenylpropanol

BenzeneMethanol, α-(2-chloroethyl)-

Fluoxetine impurity 5

3-Chloro-1-phenyl-1-propanol &gt

α-(2-Chloroethyl)benzenemethanol

3-Chloro-1-phenylpropan-1-ol , 3-Chloro-1-phenyl-propanol

18776-12-0

Aromatics

Intermediates

Benzene derivatives