(S)-3-Chloro-1-phenyl-1-propanol

Product Name: (S)-3-Chloro-1-phenyl-1-propanol
CAS No.: 100306-34-1
Chemical Name: (S)-3-Chloro-1-phenyl-1-propanol
Synonyms: Dapoxetine Impurity 37;3-CHLORO-1-PHENYL-1-PROPANOL;S(-)-3-CHLORO-1-PHENYLPROPANOL;a-(2-Chloroethyl)benzenemethanol;α-(2-Chloroethyl)benzenemethanol;(1S)-3-Chloro-1-phenylpropan-1-ol;2-(102-Chlorobenzoyl)benzoic&acid;ALPHA-(2-CHLOROETHYL)-BENZYL ALCOHOL;(S)-(-)-3-CHLORO-1-PHENYL-1-PROPANOL;(aS)-α-(2-Chloroethyl)benzenemethanol
CBNumber: CB1222267
Molecular Formula: C9H11ClO
Formula Weight: 170.64
MOL File: 100306-34-1.mol

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(S)-3-Chloro-1-phenyl-1-propanol Property

Melting point:: 58-60 °C (lit.)
Boiling point:: 296 °C
Density: 1.149
Flash point:: 132 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Solid
pka: 13.92±0.20(Predicted)
color: White to Off-White
optical activity: [α]19/D 25°, c = 1 in chloroform
InChI: InChI=1S/C9H11ClO/c10-7-6-9(11)8-4-2-1-3-5-8/h1-5,9,11H,6-7H2/t9-/m0/s1
InChIKey: JZFUHAGLMZWKTF-VIFPVBQESA-N
SMILES: C1C=C([C@@H](O)CCCl)C=CC=1
CAS DataBase Reference: 100306-34-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-38-37-36
Safety Statements: 26-37/39-39-37
WGK Germany: 3
HS Code: 29062990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 324612
Product name: (S)-(?)-3-Chloro-1-phenyl-1-propanol
Purity: 98%
Packaging: 1g
Price: $104
Updated: 2023/01/07

Sigma-Aldrich

Product number: 324612
Product name: (S)-(?)-3-Chloro-1-phenyl-1-propanol
Purity: 98%
Packaging: 5g
Price: $150
Updated: 2023/01/07

TCI Chemical

Product number: C2424
Product name: (S)-(-)-3-Chloro-1-phenyl-1-propanol
Purity: >98.0%(GC)
Packaging: 1g
Price: $78
Updated: 2025/07/31

TRC

Product number: C379595
Product name: (S)-(-)-3-Chloro-1-phenyl-1-propanol
Packaging: 10g
Price: $360
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC19994
Product name: (S)-(-)-3-Chloro-1-phenyl-1-propanol
Packaging: 2g
Price: $363.4
Updated: 2021/12/16

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(S)-3-Chloro-1-phenyl-1-propanol Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

(S)-(-)-3-Chloro-1-phenyl-1-propanol (cas# 100306-34-1) is a compound useful in organic synthesis.

Synthesis

936-59-4

100306-34-1

The general procedure for the synthesis of (S)-(-)-3-chloro-1-phenyl-1-propanol from 3-chloropropiophenone was as follows: 3.36 g (40.0 mmol) of potassium formate (HCOOK) was used as a hydrogen source under argon protection, 2.609 mg (4.0 μmol) of Cp*IrCl[(S,S)-MsDPEN] was used as a catalyst, and 1.349 g (8.0 mmol) β-chloropropiophenone in a 20 mL Schlenk tube. 2 mL of water and 2 mL of toluene were added to the reaction system and the resulting mixture was stirred at 50 °C for 24 hours. Upon completion of the reaction, the organic phase was washed three times with 3 mL of water, followed by distillation under reduced pressure to remove toluene to give optically active (S)-(-)-3-chloro-1-phenyl-1-propanol. The optical purity of the product was confirmed by GC analysis to be 85% ee in 94% yield.

References

[1] Patent: US2009/62573, 2009, A1. Location in patent: Page/Page column 7; 14
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 6, p. 1009 - 1017
[3] Patent: KR2015/116956, 2015, A. Location in patent: Paragraph 0176-0179
[4] Patent: KR2016/44117, 2016, A. Location in patent: Paragraph 0063-0066
[5] Organic and Biomolecular Chemistry, 2011, vol. 9, # 10, p. 3854 - 3862

(S)-3-Chloro-1-phenyl-1-propanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-Chloro-1-phenyl-1-propanol Suppliers

Americas 1 Canada 2 China 181 Europe 1 France 2 Germany 2 India 7 Japan 1 Slovakia 1 South Korea 2 Switzerland 1 United Kingdom 10 United States 32 Global 243

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View Lastest Price from (S)-3-Chloro-1-phenyl-1-propanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-3-Chloro-1-phenyl-1-propanol 100306-34-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-09

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Dapoxetine Impurity 77 100306-34-1
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2024-05-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-3-Chloro-1-phenyl-1-propanol 100306-34-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

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(S)-(-)-3-Chloro-1-phenyl-1-propanol &gt

2-(102-Chlorobenzoyl)benzoic&acid

(<i>S</i>)-(?)-3-Chloro-1-phenyl-1-propanol

100306-34-1

C9H11ClO

Alcohols

Organic Building Blocks

Chiral Building Blocks

Asymmetric Synthesis

Aromatics Compounds

Aromatics

Chiral Reagents

Heterocyclic Compounds

chiral