ChemicalBook > CAS DataBase List > 3-CHLORO-1-PHENYL-1-PROPANOL

3-CHLORO-1-PHENYL-1-PROPANOL

Product Name
3-CHLORO-1-PHENYL-1-PROPANOL
CAS No.
18776-12-0
Chemical Name
3-CHLORO-1-PHENYL-1-PROPANOL
Synonyms
Fluoxetine impurity 5;3-CHLORO-1-PHENYLPROPANOL;rac 3-Chloro-1-phenylpropanol;α-(2-Chloroethyl)benzenemethanol;3-Chloro-1-phenyl-1-propanol >BenzeneMethanol, α-(2-chloroethyl)-;3-Chloro-1-phenylpropan-1-ol , 3-Chloro-1-phenyl-propanol
CBNumber
CB41090893
Molecular Formula
C9H11ClO
Formula Weight
170.64
MOL File
18776-12-0.mol
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3-CHLORO-1-PHENYL-1-PROPANOL Property

Melting point:
31.0 to 36.0 °C
Boiling point:
116°C/4mmHg(lit.)
Density 
1.1344 g/cm3
refractive index 
1.54
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
13.92±0.20(Predicted)
color 
White to Off-White
InChIKey
JZFUHAGLMZWKTF-UHFFFAOYSA-N
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Safety

HS Code 
2906.29.6000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2904
Product name
3-Chloro-1-phenyl-1-propanol
Purity
>98.0%(GC)
Packaging
5g
Price
$112
Updated
2025/07/31
TCI Chemical
Product number
C2904
Product name
3-Chloro-1-phenyl-1-propanol
Purity
>98.0%(GC)
Packaging
25g
Price
$391
Updated
2025/07/31
Usbiological
Product number
288653
Product name
rac 3-chloro-1-phenylpropanol
Packaging
25mg
Price
$446
Updated
2021/12/16
TRC
Product number
C379650
Product name
rac3-Chloro-1-phenylpropanol
Packaging
250mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-W019837
Product name
α-(2-Chloroethyl)benzenemethanol
Purity
99.60%
Packaging
500g
Price
$655
Updated
2021/12/16
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3-CHLORO-1-PHENYL-1-PROPANOL Chemical Properties,Usage,Production

Uses

An intermediate of racemic Atomoxetine.

Synthesis

936-59-4

18776-12-0

General procedure for the synthesis of 3-chloro-1-phenylpropan-1-one from 3-chloropropiophenone: 3-chloro-1-phenylpropan-1-one (7.80 g, 46.26 mmol) was dissolved in a solvent mixture of THF (35 mL) and EtOH (35 mL) at -10 °C and protected by nitrogen with stirring. Sodium borohydride (2.20 g, 48.83 mmol) was added in batches over 10 min. The reaction mixture was continued to be stirred at -5 °C for 10 min, followed by slow pouring into a stirring mixture of saturated aqueous ammonium chloride solution (85 mL) and ice (40 g). The mixture was extracted twice with ether, the organic phases were combined, dried and the solvent was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, gradient from 100/0 to 95/5) to give 3-chloro-1-phenylpropanol (7.50 g, 95% yield) as a pale yellow oil. Nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3) δ: 7.39 (d, 5H), 4.91-5.01 (m, 1H), 3.70-3.83 (m, 1H), 3.59 (s, 1H), 2.20-2.32 (m, 1H), 2.11 (d, 1H).

References

[1] Pharmaceutical Research, 2017, vol. 34, # 12, p. 2873 - 2890
[2] Biological and Pharmaceutical Bulletin, 2011, vol. 34, # 4, p. 538 - 544
[3] Patent: WO2016/67043, 2016, A1. Location in patent: Page/Page column 325
[4] Organic Process Research and Development, 2000, vol. 4, # 6, p. 513 - 519
[5] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 11, p. 1767 - 1769

3-CHLORO-1-PHENYL-1-PROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-CHLORO-1-PHENYL-1-PROPANOL manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Chloro-1-phenylpropanol 18776-12-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Chloro-1-phenylpropanol 18776-12-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
3-CHLORO-1-PHENYL-1-PROPANOL 18776-12-0
Price
US $1.80-3.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
88KG
Release date
2019-09-04

18776-12-0, 3-CHLORO-1-PHENYL-1-PROPANOLRelated Search:

Dapoxetine (S)-3-PHENYL-BETA-ALANINOL HCL (S)-3-Dimethylamino-3-phenylpropanol 3-AMINO-3-PHENYL-1-PROPANOL (S)-3-Amino-3-phenylpropan-1-ol (1R)-3-Chloro-1-phenyl-propan-1-ol (S)-3-Chloro-1-phenyl-1-propanol Z-3-Chloro-1-(2-chlorophenyl)-2-(4-fluorophenyl)-oxirane TRIDIPHANE (R)-3-CHLORO-1-(3,4-DICHLORO-PHENYL)-PROPAN-1-OL 3-CHLORO-1-PHENYL-1-PROPANOL (S)-3-CHLORO-1-(3,4-DICHLORO-PHENYL)-PROPAN-1-OL (S)-3-CHLORO-1-PHENYL-1-[2-METHYL-PHENOXYL]PROPANE 1,1-DICHLORO-1A-(4-ETHOXYPHENYL)-7-O-TOLYL-1,1A,7,7A-TETRAHYDROCYCLOPROPA[B]CHROMENE AURORA KA-4840 (R)-3-CHLORO-1-PHENYL-1-[2-METHYL-PHENOXYL]PROPANE 1-chloro-4-(3-chloro-1-methoxypropyl)benzene 1,1-DICHLORO-1A-(4-ETHOXYPHENYL)-7-PHENYL-1,1A,7,7A-TETRAHYDROCYCLOPROPA[B]CHROMENE

  • 3-CHLORO-1-PHENYLPROPANOL
  • rac 3-Chloro-1-phenylpropanol
  • BenzeneMethanol, α-(2-chloroethyl)-
  • Fluoxetine impurity 5
  • 3-Chloro-1-phenyl-1-propanol &gt
  • α-(2-Chloroethyl)benzenemethanol
  • 3-Chloro-1-phenylpropan-1-ol , 3-Chloro-1-phenyl-propanol
  • 18776-12-0
  • Aromatics
  • Intermediates
  • Benzene derivatives