ChemicalBook > CAS DataBase List > 4-AMINO-3-PYRIDINECARBOXAMIDE

4-AMINO-3-PYRIDINECARBOXAMIDE

Product Name
4-AMINO-3-PYRIDINECARBOXAMIDE
CAS No.
7418-66-8
Chemical Name
4-AMINO-3-PYRIDINECARBOXAMIDE
Synonyms
4-aminonicotinamide;4-Amino-3-pyridinecarboxa...;4-AMINO-3-PYRIDINECARBOXAMIDE;4-Aminopyridine-3-carboxamide;3-Pyridinecarboxamide, 4-amino-;4-aminonicotinamide hydrochloride;3-Pyridinecarboxamide,4-amino-(9CI);4-AMino-3-pyridinecarboxaMide hydrochloride;4-AMINO-3-PYRIDINECARBOXAMIDE ISO 9001：2015 REACH
CBNumber
CB41091739
Molecular Formula
C6H7N3O
Formula Weight
137.14
MOL File
7418-66-8.mol
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4-AMINO-3-PYRIDINECARBOXAMIDE Property

Melting point:
229.5-230.5 °C
Boiling point:
377.8±22.0 °C(Predicted)
Density 
1.323±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
14.60±0.50(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xn
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A616615
Product name
4-Amino-3-pyridinecarboxamide
Packaging
25mg
Price
$45
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
A11871
Product name
4-Aminopyridine-3-carboxamide
Purity
95%
Packaging
1g
Price
$110
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
CAPOA11871
Product name
4-Aminopyridine-3-carboxamide
Purity
95%
Packaging
1g
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA45597
Product name
4-Aminopyridine-3-carboxamide
Packaging
100mg
Price
$115
Updated
2021/12/16
AK Scientific
Product number
W8196
Product name
4-Amino-3-pyridinecarboxamide
Packaging
250mg
Price
$117
Updated
2021/12/16
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4-AMINO-3-PYRIDINECARBOXAMIDE Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow crystal powder

Synthesis

7418-65-7

7418-66-8

General procedure for the synthesis of 4-amino-3-carboxamido pyridine from 4-aminopyridine-3-carboxylic acid: To a stirring solution of 4-aminopyridine-3-carboxylic acid (3 g, 0.013 mol) in THF (50 mL) was added dropwise SOCl2 (3.6 mL, 0.045 mol) and a catalytic amount of DMF (30 μL) at room temperature and protected by argon gas. The reaction mixture was stirred until TLC showed complete consumption of the feedstock. Upon completion of the reaction, the volatiles were removed under reduced pressure to give the crude product. The crude product was dissolved in THF (30 mL) and cooled to 0 °C, followed by slow addition of 7N NH3-methanol solution (22 mL). The reaction mixture was gradually warmed to room temperature and stirring was continued for 4 hours. At the end of the reaction, the precipitate was collected by filtration and the filtrate was concentrated under reduced pressure to give the crude compound. The crude compound was purified by column chromatography (using 100-200 mesh silica gel, 60 g, eluent 10% MeOH-10% NH4OH/DCM) to give 4-amino-3-carboxamido pyridine (475 mg, 27% yield), which was used in the next step of the reaction without further purification.LCMS (ESI+): m/z: 138.33 [M + H]+.

References

[1] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 98; 100

4-AMINO-3-PYRIDINECARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-3-PYRIDINECARBOXAMIDE Suppliers

China 78 Europe 1 Germany 1 India 2 United Kingdom 2 United States 7 Global 91
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
ProdList
96815
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76
Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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18207
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66
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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10186
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Tetranov Biopharm
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13526569071
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sales@leadmedpharm.com
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China
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7892
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ZEROSCHEM.CO.,LTD.
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10-61256048 13810278579
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+86 10 61256049
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sales@zeroschem.com
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China
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Chemsky（shanghai）International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
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China
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32321
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50
Xuchang Haofeng Chemical Co., Ltd.
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0374-5695198
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0374-5695198
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haofengchemical@163.com
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China
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50
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Shanghai Sunway Pharmaceutical Technology Co., Ltd
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18270980682
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021 51613951
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mlcheng@sunwaypharm.cn
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China
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Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
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2819742715@qq.com
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China
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4000
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NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
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View Lastest Price from 4-AMINO-3-PYRIDINECARBOXAMIDE manufacturers

Dideu Industries Group Limited
Product
4-AMINO-3-PYRIDINECARBOXAMIDE 7418-66-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-27
Career Henan Chemical Co
Product
4-AMINO-3-PYRIDINECARBOXAMIDE 7418-66-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-23

7418-66-8, 4-AMINO-3-PYRIDINECARBOXAMIDERelated Search:

5-AMINO-3-PYRIDINEMETHANAMINE 3-AMINO-4-PYRIDINECARBOXAMIDE 5-AMINO-3-PYRIDINECARBOXAMIDE N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide 2-Amino-3-pyridinecarboxamide 6-AMINO-3-PYRIDINECARBOXAMIDE 1,6,8-TRIMETHYL-1,2,3,6-TETRAHYDRODIPYRAZOLO[3,4-B:3,4-D]PYRIDIN-3-ONE 4,6-DIMETHYL-1,2-DIHYDRO-PYRAZOLO[4,3-C]PYRIDIN-3-ONE AURORA KA-5149 AURORA KA-5124 AURORA KA-5125 AURORA KA-5130 AURORA KA-5126 AURORA KA-5147 AURORA KA-5148 AURORA KA-5146 AURORA KA-4802 5-ANILINO-1,3-DIMETHYL-7-[(TRIPHENYL-LAMBDA5-PHOSPHANYLIDENE)AMINO]PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE

  • 4-AMINO-3-PYRIDINECARBOXAMIDE
  • 3-Pyridinecarboxamide,4-amino-(9CI)
  • 4-aminonicotinamide
  • 4-Aminopyridine-3-carboxamide
  • 4-Amino-3-pyridinecarboxa...
  • 4-AMino-3-pyridinecarboxaMide hydrochloride
  • 3-Pyridinecarboxamide, 4-amino-
  • 4-AMINO-3-PYRIDINECARBOXAMIDE ISO 9001：2015 REACH
  • 4-aminonicotinamide hydrochloride
  • 7418-66-8
  • Heterocycle-Pyridine series
  • Building Blocks
  • AMIDE
  • Pyridine