3-AMINO-4-PYRIDINECARBOXAMIDE

Product Name: 3-AMINO-4-PYRIDINECARBOXAMIDE
CAS No.: 64188-97-2
Chemical Name: 3-AMINO-4-PYRIDINECARBOXAMIDE
Synonyms: 3-Amino-isonicotimide;3-AMINOISONICOTINAMIDE;Olutasidenib Impurity 31;3-aMino-4-carbaMoylpyridine;3-Aminopyridin-4-carboxamide;3-AMINO-4-PYRIDINECARBOXAMIDE;3-Aminoisopyridin-3-carboxamide;4-Pyridinecarboxamide, 3-amino-;methyl 3-aminoisonicotinate (en);4-Pyridinecarboxamide,3-amino-(9CI)
CBNumber: CB9696536
Molecular Formula: C6H7N3O
Formula Weight: 137.14
MOL File: 64188-97-2.mol

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3-AMINO-4-PYRIDINECARBOXAMIDE Property

Melting point:: 84-86°
Boiling point:: 369.2±22.0 °C(Predicted)
Density: 1.323±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 14.73±0.50(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A604793
Product name: 3-Aminoisonicotinamide
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA54432
Product name: 3-Aminopyridine-4-carboxamide
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR2138
Product name: 3-Aminoisonicotinamide
Packaging: 1g
Price: $89
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: A12440
Product name: 3-Aminopyridine-4-carboxamide
Purity: 92%
Packaging: 5g
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: W7596
Product name: 3-Aminoisonicotinamide
Packaging: 1g
Price: $95
Updated: 2021/12/16

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3-AMINO-4-PYRIDINECARBOXAMIDE Chemical Properties,Usage,Production

Synthesis

7579-20-6

64188-97-2

General procedure for the synthesis of 3-aminoisonicotinamide from 3-aminoisonicotinic acid: ammonium hydrochloride (4.98 g, 93.2 mmol) was mixed with 3-aminoisonicotinic acid (9.90 g, 71.7 mmol) to which was added 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1 ,1,3,3-tetramethylene diuronium hexafluorophosphate (V) ( 35.4 g, 93.2 mmol) and N-ethyl-N-isopropylpropan-2-amine (37.5 mL, 215.02 mmol) in a solution of DMF (100 mL). The reaction mixture was stirred at 40 °C for 72 h under nitrogen protection. After completion of the reaction, the solvent was removed by evaporation to give the crude product. The crude product was purified by fast silica gel column chromatography using a gradient elution with a dichloromethane solution of 5% methanol. The purified grades were collected and evaporated to dryness to give 3-aminoisonicotinamide (8.57 g, 87% yield) as a yellow gel.

References

[1] Synthesis (Germany), 2016, vol. 48, # 8, p. 1226 - 1234
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 5, p. 1623 - 1642
[3] Patent: WO2013/12915, 2013, A1. Location in patent: Paragraph 00674-00676
[4] European Journal of Medicinal Chemistry, 2018, vol. 152, p. 235 - 252
[5] Patent: WO2007/117161, 2007, A1. Location in patent: Page/Page column 24-25

3-AMINO-4-PYRIDINECARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-4-PYRIDINECARBOXAMIDE Suppliers

China 90 Czech Republic 1 Europe 1 Germany 1 India 1 United Kingdom 3 United States 7 Global 104

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View Lastest Price from 3-AMINO-4-PYRIDINECARBOXAMIDE manufacturers

Career Henan Chemical Co

Product: 3-AMINO-4-PYRIDINECARBOXAMIDE 64188-97-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

64188-97-2, 3-AMINO-4-PYRIDINECARBOXAMIDERelated Search:

N(2,6 Dichloro-4 Methyl-3-Pyridyl-2-Cyclopropyl Amino)-3-Pyridinecarboxamide 5-AMINO-3-PYRIDINECARBOXAMIDE N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide 4-AMINO-3-PYRIDINECARBOXAMIDE 2-Amino-3-pyridinecarboxamide 6-AMINO-3-PYRIDINECARBOXAMIDE 1-[(2,3-DIAMINO-4-PYRIDINYL)CARBONYL]-PIPERIDINE 3-Amino-N-(2,4,6-trimethylphenyl)-4-pyridinecarboxamide 3-AMINO-4-PYRIDINECARBOXAMIDE 3-AMINO-2-CHLORO-ISONICOTINAMIDE PYRIDO[3,4-D]PYRIMIDINE-2,4(1H,3H)-DIONE 2-ETHYLPYRIDO[3,4-D]PYRIMIDIN-4(1H)-ONE 2,3-DIHYDRO-2-THIOXO-PYRIDO[3,4-D]PYRIMIDIN-4(1H)-ONE 3-NITRO-4-PYRIDINECARBOXAMIDE

3-Amino-isonicotimide

3-AMINOISONICOTINAMIDE

3-AMINO-4-PYRIDINECARBOXAMIDE

4-Pyridinecarboxamide,3-amino-(9CI)

methyl 3-aminoisonicotinate (en)

3-aMino-4-carbaMoylpyridine

3-amino(38C5,38N)pyridine-4-carboxamide

4-Pyridinecarboxamide, 3-amino-

3-Aminopyridin-4-carboxamide

Olutasidenib Impurity 31

3-Aminoisopyridin-3-carboxamide

64188-97-2

AMIDE

Pyridines

Pyridine