ChemicalBook > CAS DataBase List > 5-Trifluoromethyl-pyridine-3-boronic acid

5-Trifluoromethyl-pyridine-3-boronic acid

Product Name
5-Trifluoromethyl-pyridine-3-boronic acid
CAS No.
947533-51-9
Chemical Name
5-Trifluoromethyl-pyridine-3-boronic acid
Synonyms
3-Borono-5-(trifluoromethyl)pyridine;5-TrifluoroMethyl-3-pyridineboric acid;5-TRIFLUOROMETHYL-PYRIDINE-3-BORONIC ACI;3-trifluoromethyl-5-pyridyl boronic acid;5-Trifluoromethyl-pyridine-3-boronic acid;[5-(Trifluoromethyl)-3-pyridyl]boronic acid;[5-(trifluoromethyl)-3-pyridinyl]boronic acid;(5-(Trifluoromethyl)pyridin-3-yl)boronic acid;(5-Trifluoromethylpyridin-3-yl)boronic acid, 95%;BP 33117 5-TRIFLUOROMETHYL-PYRIDINE-3-BORONIC ACID
CBNumber
CB41113349
Molecular Formula
C6H5BF3NO2
Formula Weight
190.92
MOL File
947533-51-9.mol
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5-Trifluoromethyl-pyridine-3-boronic acid Property

Melting point:
300.8 °C (decomp)
Boiling point:
299.9±50.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Crystalline Powder
pka
5.90±0.10(Predicted)
color 
White to yellow
InChI
InChI=1S/C6H5BF3NO2/c8-6(9,10)4-1-5(7(12)13)3-11-2-4/h1-3,12-13H
InChIKey
SFBQNNGMEKUJAN-UHFFFAOYSA-N
SMILES
B(C1=CC(C(F)(F)F)=CN=C1)(O)O
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Safety

HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
T899413
Product name
(5-(Trifluoromethyl)pyridin-3-yl)boronicAcid
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC7177
Product name
5-(Trifluoromethyl)pyridine-3-boronicacid
Purity
95%
Packaging
250mg
Price
$375
Updated
2021/12/16
SynQuest Laboratories
Product number
8H60-3-Y3
Product name
5-(Trifluoromethyl)pyridine-3-boronic acid
Packaging
250mg
Price
$395
Updated
2021/12/16
Apolloscientific
Product number
PC7177
Product name
5-(Trifluoromethyl)pyridine-3-boronicacid
Purity
95%
Packaging
1g
Price
$519
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BOR0002576
Product name
5-TRIFLUOROMETHYL-PYRIDINE-3-BORONIC ACID
Purity
95.00%
Packaging
1G
Price
$771.75
Updated
2021/12/16
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5-Trifluoromethyl-pyridine-3-boronic acid Chemical Properties,Usage,Production

Synthesis

5419-55-6

436799-33-6

947533-51-9

Under nitrogen protection, 3-bromo-5-(trifluoromethyl)pyridine (2.5 g, 11.06 mmol) and triisopropyl borate (3.06 mL, 13.27 mmol) were dissolved in anhydrous tetrahydrofuran (20 mL) and cooled to -78 °C. A hexane solution of n-butyllithium (2.5 M, 4.9 mL, 12.17 mmol) was slowly added dropwise, keeping the reaction mixture stirred at -78 °C for 3 hours. Subsequently, the reaction mixture was slowly warmed to -10 °C. The reaction was quenched by addition of water (20 mL) and the tetrahydrofuran was removed by distillation under reduced pressure. The remaining aqueous phase was diluted with water (40 mL) and washed with ether (2 x 40 mL). The aqueous phase was adjusted to pH 5 with acetic acid and the resulting suspension was extracted with ethyl acetate (80 mL). The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 3-(trifluoromethyl)pyridine-5-boronic acid as a brown solid (2.022 g, 96% yield). HPLC/MS analysis: retention time 1.47 min, mass-to-charge ratio 192.1 (M+H+).

References

[1] Patent: US2014/135320, 2014, A1. Location in patent: Paragraph 0224; 0225

5-Trifluoromethyl-pyridine-3-boronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Trifluoromethyl-pyridine-3-boronic acid manufacturers

Career Henan Chemical Co
Product
5-Trifluoromethyl-pyridine-3-boronic acid 947533-51-9
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

947533-51-9, 5-Trifluoromethyl-pyridine-3-boronic acidRelated Search:

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