5-Trifluoromethyl-pyridine-3-boronic acid
- Product Name
- 5-Trifluoromethyl-pyridine-3-boronic acid
- CAS No.
- 947533-51-9
- Chemical Name
- 5-Trifluoromethyl-pyridine-3-boronic acid
- Synonyms
- 3-Borono-5-(trifluoromethyl)pyridine;5-TrifluoroMethyl-3-pyridineboric acid;5-TRIFLUOROMETHYL-PYRIDINE-3-BORONIC ACI;3-trifluoromethyl-5-pyridyl boronic acid;5-Trifluoromethyl-pyridine-3-boronic acid;[5-(Trifluoromethyl)-3-pyridyl]boronic acid;[5-(trifluoromethyl)-3-pyridinyl]boronic acid;(5-(Trifluoromethyl)pyridin-3-yl)boronic acid;(5-Trifluoromethylpyridin-3-yl)boronic acid, 95%;BP 33117 5-TRIFLUOROMETHYL-PYRIDINE-3-BORONIC ACID
- CBNumber
- CB41113349
- Molecular Formula
- C6H5BF3NO2
- Formula Weight
- 190.92
- MOL File
- 947533-51-9.mol
5-Trifluoromethyl-pyridine-3-boronic acid Property
- Melting point:
- 300.8 °C (decomp)
- Boiling point:
- 299.9±50.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- pka
- 5.90±0.10(Predicted)
- color
- White to yellow
- InChI
- InChI=1S/C6H5BF3NO2/c8-6(9,10)4-1-5(7(12)13)3-11-2-4/h1-3,12-13H
- InChIKey
- SFBQNNGMEKUJAN-UHFFFAOYSA-N
- SMILES
- B(C1=CC(C(F)(F)F)=CN=C1)(O)O
Safety
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T899413
- Product name
- (5-(Trifluoromethyl)pyridin-3-yl)boronicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC7177
- Product name
- 5-(Trifluoromethyl)pyridine-3-boronicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- 8H60-3-Y3
- Product name
- 5-(Trifluoromethyl)pyridine-3-boronic acid
- Packaging
- 250mg
- Price
- $395
- Updated
- 2021/12/16
- Product number
- PC7177
- Product name
- 5-(Trifluoromethyl)pyridine-3-boronicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $519
- Updated
- 2021/12/16
- Product number
- BOR0002576
- Product name
- 5-TRIFLUOROMETHYL-PYRIDINE-3-BORONIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $771.75
- Updated
- 2021/12/16
5-Trifluoromethyl-pyridine-3-boronic acid Chemical Properties,Usage,Production
Synthesis
5419-55-6
436799-33-6
947533-51-9
Under nitrogen protection, 3-bromo-5-(trifluoromethyl)pyridine (2.5 g, 11.06 mmol) and triisopropyl borate (3.06 mL, 13.27 mmol) were dissolved in anhydrous tetrahydrofuran (20 mL) and cooled to -78 °C. A hexane solution of n-butyllithium (2.5 M, 4.9 mL, 12.17 mmol) was slowly added dropwise, keeping the reaction mixture stirred at -78 °C for 3 hours. Subsequently, the reaction mixture was slowly warmed to -10 °C. The reaction was quenched by addition of water (20 mL) and the tetrahydrofuran was removed by distillation under reduced pressure. The remaining aqueous phase was diluted with water (40 mL) and washed with ether (2 x 40 mL). The aqueous phase was adjusted to pH 5 with acetic acid and the resulting suspension was extracted with ethyl acetate (80 mL). The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 3-(trifluoromethyl)pyridine-5-boronic acid as a brown solid (2.022 g, 96% yield). HPLC/MS analysis: retention time 1.47 min, mass-to-charge ratio 192.1 (M+H+).
References
[1] Patent: US2014/135320, 2014, A1. Location in patent: Paragraph 0224; 0225
5-Trifluoromethyl-pyridine-3-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Trifluoromethyl-pyridine-3-boronic acid manufacturers
- Product
- 5-Trifluoromethyl-pyridine-3-boronic acid 947533-51-9
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09