ChemicalBook > CAS DataBase List > MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE

MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE

Product Name
MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE
CAS No.
65144-34-5
Chemical Name
MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE
Synonyms
SPCK;HLE INHIBITOR;MEOSUC-AAPV-CMK;MEOSUC-APPV-CMK;ELASTASE INHIBITOR III;Elastase Inhibitor, SPCK;MEOSUC-ALA-ALA-PRO-VAL-CMK;N-(METHOXYSUCCINYL)-L-ALA-L-ALA-L-PROL.&;MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE;methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
CBNumber
CB4111744
Molecular Formula
C22H35ClN4O7
Formula Weight
502.99
MOL File
65144-34-5.mol
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MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE Property

Melting point:
159-161 °C
Boiling point:
809.4±65.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
ethanol: 50 mg/mL, clear, colorless
pka
13.05±0.20(Predicted)
form 
Solid
Sensitive 
Moisture Sensitive
BRN 
6167019
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M0398
Product name
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
Purity
elastase inhibitor
Packaging
5mg
Price
$170
Updated
2024/03/01
Sigma-Aldrich
Product number
M0398
Product name
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
Purity
elastase inhibitor
Packaging
10mg
Price
$291
Updated
2024/03/01
Sigma-Aldrich
Product number
324745
Product name
Elastase Inhibitor III
Purity
The Elastase Inhibitor III controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging
5MG
Price
$238
Updated
2023/06/20
Alfa Aesar
Product number
J65894
Product name
Elastase Inhibitor III
Packaging
5mg
Price
$123
Updated
2021/12/16
Sigma-Aldrich
Product number
M0398
Product name
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
Purity
elastase inhibitor
Packaging
25mg
Price
$549
Updated
2024/03/01
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MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE Chemical Properties,Usage,Production

Uses

A potent irreversible inhibitor of human leukocyte elastase

Definition

ChEBI: A tripeptide derived from methoxysuccinyl-Ala-Ala-Pro-Val by conversion of the terminal carboxy group to the corresponding chloromethyl ketone.

General Description

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is a tetrapeptide, cell-permeable and non-cytotoxic inhibitor.

Biochem/physiol Actions

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone acts as a competitive inhibitor of human leukocyte elastase (HLE).

MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE Preparation Products And Raw materials

Raw materials

Preparation Products

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MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE Suppliers

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65144-34-5, MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONERelated Search:

Elastase 2-AMINO-1-PYRROLIDIN-1-YL-ETHANONE HCL N,N-DIETHYL-2-(METHYLAMINO)ACETAMIDE HYDROCHLORIDE N-ME-GLY-NME2 1-ACETAMIDO-ACETONE MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE H-ALA-PRO-NH2 HCL Methyl 4-aminobutyrate hydrochloride H-ALA-ALA-ALA-NH2 HCL 2-AMINO-N,N-DIETHYL-ACETAMIDE HCL N-(1-methyl-2-oxopropyl)acetamide ALA-ALA-PRO-VAL-CMK H-PRO-NHET HCL 2-METHYLAMINO-1-PYRROLIDIN-1-YL-ETHANONE X HCL >98% MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE

  • N-(METHOXYSUCCINYL)-L-ALANYL-L-ALANYL-L-PROLYL-L-VALINE CHLOROMETHYLKETONE
  • methoxysuccinyl-alanyl-alanyl-prolyl-valinechloromethylketone
  • N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL CHLOROMETHYL KETONE
  • MEOSUC-APPV-CMK
  • MEOSUC-AAPV-CMK
  • MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE
  • MEOSUC-ALA-ALA-PRO-VAL-CMK
  • ELASTASE INHIBITOR III
  • HLE INHIBITOR
  • N-(methoxysuccinyl)-L-ala-L-ala-L-prol.-L-val-chlorome.ket.
  • N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL*CHLORO METHYL KETO
  • N-(METHOXYSUCCINYL)-L-ALA-L-ALA-L-PROL.&
  • N(methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine CMK
  • SPCK
  • Elastase Inhibitor, SPCK
  • methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
  • methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
  • L-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-
  • 65144-34-5
  • C22H35ClN4O7
  • C22H35N4O7Cl
  • Biochemicals and Reagents
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Metalloproteinase Inhibitors
  • Cytoskeleton and Extracellular Matrix
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • Extracellular Matrix
  • Substrate Analogs
  • ProteaseInhibitors