ChemicalBook > CAS DataBase List > N-[4-(-Carboxycyclohexylmethyl)]maleimide

N-[4-(-Carboxycyclohexylmethyl)]maleimide

Product Name
N-[4-(-Carboxycyclohexylmethyl)]maleimide
CAS No.
64987-82-2
Chemical Name
N-[4-(-Carboxycyclohexylmethyl)]maleimide
Synonyms
Mal-Cyclohexanecarboxylicacid;4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl);4-(N-MaleiMidoMethyl)cyclohexanecarboxylic acid;4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 95%;4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarboxylic acid;4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylic acid;4-(Maleimidomethyl)cyclohexanecarboxylic Acid (Discontinued, see C177860);4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]Cyclohexanecarboxylic acid;Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-;4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexane-1-carboxylic acid
CBNumber
CB41176520
Molecular Formula
C12H15NO4
Formula Weight
237.25
MOL File
64987-82-2.mol
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N-[4-(-Carboxycyclohexylmethyl)]maleimide Property

Melting point:
157-158°C
Boiling point:
433.6±18.0 °C(Predicted)
Density 
1.329±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform, Methanol
form 
Solid
pka
4.80±0.10(Predicted)
color 
Pale Yellow
InChI
InChI=1S/C12H15NO4/c14-10-5-6-11(15)13(10)7-8-1-3-9(4-2-8)12(16)17/h5-6,8-9H,1-4,7H2,(H,16,17)
InChIKey
LQILVUYCDHSGEU-UHFFFAOYSA-N
SMILES
C1(C(O)=O)CCC(CN2C(=O)C=CC2=O)CC1
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Safety

HS Code 
2925.19.9100
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3218
Product name
4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid
Packaging
1G
Price
$234
Updated
2024/03/01
TCI Chemical
Product number
M3218
Product name
4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid
Packaging
5G
Price
$819
Updated
2024/03/01
TRC
Product number
C177860
Product name
N-[4-(-Carboxycyclohexylmethyl)]maleimide
Packaging
25mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC19767
Product name
N-[4-(-Carboxycyclohexylmethyl)]maleimide
Packaging
5G
Price
$150
Updated
2021/12/16
AK Scientific
Product number
J95578
Product name
N-[4-(-Carboxycyclohexylmethyl)]maleimide
Packaging
250mg
Price
$160
Updated
2021/12/16
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N-[4-(-Carboxycyclohexylmethyl)]maleimide Chemical Properties,Usage,Production

Description

4-((2,5-Dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarboxylic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Chemical Properties

White Solid

Uses

A sulfhydryl crosslinking reagent.

Uses

An amino reactive reagent.

Definition

N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.

N-[4-(-Carboxycyclohexylmethyl)]maleimide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-[4-(-Carboxycyclohexylmethyl)]maleimide manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Mal-Cyclohexanecarboxylicacid 64987-82-2
Price
US $0.00/g
Min. Order
25g
Purity
>95.00%
Supply Ability
25g
Release date
2024-03-27

64987-82-2, N-[4-(-Carboxycyclohexylmethyl)]maleimideRelated Search:

Maleimido-Tri(Ethylene Glycol)-Propionic Acid Mal-PEG2-COOH Mal-PEG4-Acid Mal-PEG2-NHS ester Bis-Mal-Lysine-PEG4-TFP ester Maleimide-PEG4-NHS Ester Maleimide-PEG2-NHS Ester 3-Maleimidopropionic acid Mal-PEG2-acid Mal-Amido-PEG4-acid 2-MALEIMIDOETHYLAMINE HCL 4-MALEIMIDOBUTYRIC ACID 1h-pyrrole-2,5-dione, 1-[2-(2-aminoethoxy)ethyl]-, 2,2,2-trifluoroacetate (1:1) Maleimide-SS-amine Deruxtecan SMCC crosslinker SULFO-SMCC N-[4-(-Carboxycyclohexylmethyl)]maleimide

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  • 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 95%
  • 4-(N-MaleiMidoMethyl)cyclohexanecarboxylic acid
  • 4-(Maleimidomethyl)cyclohexanecarboxylic Acid (Discontinued, see C177860)
  • 4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylic acid
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  • 4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)
  • 4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexane-1-carboxylic acid
  • Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-
  • Mal-Cyclohexanecarboxylicacid
  • 64987-82-2
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