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N-Desmethyl Imatinib

Product Name
N-Desmethyl Imatinib
CAS No.
404844-02-6
Chemical Name
N-Desmethyl Imatinib
Synonyms
N-DesmethyL;Imatinib EP Impurity C;CGP-74588;STI 509-00;Norimatinib;no mesylate;Imatinib Imp.F;N-methylimatinib;DesMethyl IMatinib;Imatinib Impurity F
CBNumber
CB41176575
Molecular Formula
C28H29N7O
Formula Weight
479.58
MOL File
404844-02-6.mol
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N-Desmethyl Imatinib Property

Melting point:
99-101°C
Density 
1.268±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml
form 
A lyophilized solid
pka
13.28±0.70(Predicted)
color 
Light yellow to yellow
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Safety

Safety Statements 
24/25
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H341Suspected of causing genetic defects

H351Suspected of causing cancer

H360May damage fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16947
Product name
N-Desmethyl Imatinib
Purity
≥95%
Packaging
500μg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
16947
Product name
N-Desmethyl Imatinib
Purity
≥95%
Packaging
1mg
Price
$71
Updated
2024/03/01
Cayman Chemical
Product number
16947
Product name
N-Desmethyl Imatinib
Purity
≥95%
Packaging
5mg
Price
$275
Updated
2024/03/01
Cayman Chemical
Product number
16947
Product name
N-Desmethyl Imatinib
Purity
≥95%
Packaging
10mg
Price
$510
Updated
2024/03/01
TRC
Product number
D292045
Product name
N-DesmethylImatinib
Packaging
10mg
Price
$490
Updated
2021/12/16
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N-Desmethyl Imatinib Chemical Properties,Usage,Production

Description

N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical Properties

Off-White to Pale-Yellow Solid

Uses

aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes

Uses

anti-epileptic

Uses

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

Definition

ChEBI: N-Demethylated piperazine is a member of benzamides.

N-Desmethyl Imatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Desmethyl Imatinib Suppliers

Canada 2 China 172 France 1 India 7 United Kingdom 1 United States 17 Global 200
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
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View Lastest Price from N-Desmethyl Imatinib manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
N-Desmethyl imatinib 404844-02-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-13
Dideu Industries Group Limited
Product
N-Desmethyl Imatinib 404844-02-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-06
Career Henan Chemical Co
Product
N-Desmethyl Imatinib 404844-02-6
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-19

404844-02-6, N-Desmethyl ImatinibRelated Search:

Imatinib 1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine iMatinib related substance B 2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID Imatinib (Piperidine)-N-oxide 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Guanidine, N-(2-methyl-3-nitrophenyl)- Imatinib Impurity 7 N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide IMatinib Para-diaMinoMethylbenzene Imatinib Meta-methyl-piperazine Impurity iMatinib related substance C 3-Acetylpyridine Imatinib EP Impurity J N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE Imatinib EP Impurity D Imatinib (Pyridine)-N-oxide

  • CGP-74588
  • N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide
  • Norimatinib
  • STI 509-00
  • Imatinib impurity 6/Imatinib EP Impurity C/N-Desmethyl Imatinib/N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide
  • Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-
  • IMATINIB METABOLITE N-DESMETHYL IMATINIB (N-DESMETHYL IMATINIB)
  • N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide
  • DesMethyl IMatinib
  • DesMethyl IMatinib-d8
  • iMatinib related substance A
  • IMatinib N-DesMethyl IMpurity
  • Imatinib Impurity F
  • Imatinib metabolite N-Desmethyl Imatinib
  • Imatinib EP Impurity C
  • Imatinib EP Impurity C (N-Desmethyl Imatinib)
  • Imatinib Imp.F
  • Imatinib Impurity 6(Imatinib EP Impurity C)
  • N-Desmethyl Imatinib Impurity
  • N-DesmethyL
  • no mesylate
  • Imatinib Impurity 6（EP-C）
  • Imatinib EP Impurity C (Imatinib N-Desmethyl Impurity)
  • Imatinib Impurity C (Imatinib (Piperazine)-N1- Oxide) (crude)
  • Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide)
  • N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4...
  • Imatinib N-Desmethyl ImpurityQ: What is Imatinib N-Desmethyl Impurity Q: What is the CAS Number of Imatinib N-Desmethyl Impurity Q: What is the storage condition of Imatinib N-Desmethyl Impurity Q: What are the applications of Imatinib N-Desmethyl Impurity
  • Desmethyl imatinib D4Q: What is Desmethyl imatinib D4 Q: What is the CAS Number of Desmethyl imatinib D4 Q: What is the storage condition of Desmethyl imatinib D4 Q: What are the applications of Desmethyl imatinib D4
  • N-methylimatinib
  • Inhibitor,N Desmethyl imatinib,v-Abl,PDGFR,inhibit,NDesmethyl imatinib,Drug Metabolite,Imatinib,N-Desmethyl imatinib,c-Kit
  • N-Desmethyl lmatinib
  • 404844-02-6
  • C28H29N7O
  • Metabolite Reference Standard
  • Isotopically Labeled Pharmaceutical Reference Standard
  • Intermediates & Fine Chemicals
  • Metabolites
  • Pharmaceuticals
  • Tyrosine Kinase Inhibitors
  • Various Metabolites and Impurities