Aminoquinol

Product Name: Aminoquinol
CAS No.: 10023-54-8
Chemical Name: Aminoquinol
Synonyms: Aminoquinol;Aminoquinol DISCONTINUED. Please see C609759.;7-Chloro-2-(o-chlorostyryl)-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline;1,4-Pentanediamine, N4-[7-chloro-2-[2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-dia;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diami;N4-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediamine tris(phosphate)
CBNumber: CB41178009
Molecular Formula: C26H31Cl2N3
Formula Weight: 456.45
MOL File: 10023-54-8.mol

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Aminoquinol Property

Melting point:: 223-225°
Boiling point:: 597.1±50.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
storage temp.: RT
solubility: Soluble in DMSO (up to 25 mg/ml with warming).
form: solid
pka: 10.47±0.25(Predicted)
color: Light brown
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 009881
Product name: N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diamine triphosphate
Packaging: 1g
Price: $378
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0025379
Product name: AMINOQUINOL
Purity: 95.00%
Packaging: 5MG
Price: $501.2
Updated: 2021/12/16

AK Scientific

Product number: 7133AC
Product name: N4-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N1,N1-diethyl-pentane-1,4-diamine
Packaging: 1g
Price: $560
Updated: 2021/12/16

Aronis compounds

Product number: e00599
Product name: N4-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediaminetris(phosphate)
Packaging: 20mg
Price: $30
Updated: 2021/12/16

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Aminoquinol Chemical Properties,Usage,Production

Description

XIB4035 (10023-54-8) is a novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50?= 10.4 μM. Like GDNF, XIB4035 induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells.1?Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3? GDNF agonists may be a new class of Parkinson’s disease therapeutics.4

References

1) Tokugawa?et al. (2003),?XIB4035, a novel nonpeptidyl small molecule agonist for GFRα-1; Neurochem. Int.,?42?81 2) Hedstrom?et al. (2014),?Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling; Proc. Natl. Acad. Sci. USA,?111?2325 3) Hsieh?et al.?(2018)?Distinct TrkA and Ret modulated negative and positive neuropathic behaviors in a mouse model of resiniferatoxin-induced small fiber neuropathy; Exp. Neurol.?300?87 4) Drinkut?et al.?(2016)?Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in Parkinson disease mouse model; Cell Death Dis.,?7?e2359

Aminoquinol Preparation Products And Raw materials

Raw materials

Preparation Products

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Aminoquinol Suppliers

China 10 India 1 Russia 1 United States 3 Global 15

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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ShangHai Biochempartner Co.,Ltd

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Alfa Chemistry

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Wuhan Topule

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Changzhou Furuisi Biotechnology Co., Ltd

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Hubei Kele Fine Chemical Co., Ltd

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Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

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Shanghai jerryxing Biomedical Technology Co., Ltd

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Olix (Shanghai) Pharmaceutical Technology Co., Ltd

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10023-54-8, AminoquinolRelated Search:

A-83-01 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine SR9009 ZM 306416 hydrochloride BISDESETHYL CHLOROQUINE CHLOROQUINE 4-(4-AMINOBUTYL)AMINO-7-CHLOROQUINOLINE Aminoquinol 4-AMINO-7-CHLORO-2-METHYLQUINOLINE 4-Amino-2-picoline 2-Styrylquinoline 4-(4-AMINOBUT-1-YL)AMINOQUINOLINE ISOPROPYL-PYRIDIN-4-YL-AMINE DIHYDROCHLORIDE DESETHYL CHLOROQUINE 7-CHLORO-N-METHYLQUINOLIN-4-AMINE

N4-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediamine tris(phosphate)

Aminoquinol

7-Chloro-2-(o-chlorostyryl)-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline

N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diami

N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-dia

1,4-Pentanediamine, N4-[7-chloro-2-[2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-

Aminoquinol DISCONTINUED. Please see C609759.

10023-54-8

C26H40Cl2N3O12P3