Aminoquinol
- Product Name
- Aminoquinol
- CAS No.
- 10023-54-8
- Chemical Name
- Aminoquinol
- Synonyms
- Aminoquinol;Aminoquinol DISCONTINUED. Please see C609759.;7-Chloro-2-(o-chlorostyryl)-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline;1,4-Pentanediamine, N4-[7-chloro-2-[2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-dia;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diami;N4-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediamine tris(phosphate)
- CBNumber
- CB41178009
- Molecular Formula
- C26H31Cl2N3
- Formula Weight
- 456.45
- MOL File
- 10023-54-8.mol
Aminoquinol Property
- Melting point:
- 223-225°
- Boiling point:
- 597.1±50.0 °C(Predicted)
- Density
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- RT
- solubility
- Soluble in DMSO (up to 25 mg/ml with warming).
- form
- solid
- pka
- 10.47±0.25(Predicted)
- color
- Light brown
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 009881
- Product name
- N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diamine triphosphate
- Packaging
- 1g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- API0025379
- Product name
- AMINOQUINOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.2
- Updated
- 2021/12/16
- Product number
- 7133AC
- Product name
- N4-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N1,N1-diethyl-pentane-1,4-diamine
- Packaging
- 1g
- Price
- $560
- Updated
- 2021/12/16
- Product number
- e00599
- Product name
- N4-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediaminetris(phosphate)
- Packaging
- 20mg
- Price
- $30
- Updated
- 2021/12/16
Aminoquinol Chemical Properties,Usage,Production
Description
XIB4035 (10023-54-8) is a novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50?= 10.4 μM. Like GDNF, XIB4035 induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells.1?Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3? GDNF agonists may be a new class of Parkinson’s disease therapeutics.4
References
1) Tokugawa?et al. (2003),?XIB4035, a novel nonpeptidyl small molecule agonist for GFRα-1; Neurochem. Int.,?42?81 2) Hedstrom?et al. (2014),?Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling; Proc. Natl. Acad. Sci. USA,?111?2325 3) Hsieh?et al.?(2018)?Distinct TrkA and Ret modulated negative and positive neuropathic behaviors in a mouse model of resiniferatoxin-induced small fiber neuropathy; Exp. Neurol.?300?87 4) Drinkut?et al.?(2016)?Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in Parkinson disease mouse model; Cell Death Dis.,?7?e2359