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Loperamide

Product Name
Loperamide
CAS No.
106900-12-3
Chemical Name
Loperamide
Synonyms
R 58425;loperamide oxide;LoperaMide-d6 N-Oxide;Loperamide EP Impurity F;trans-Loperamide N-Oxide;Loperamide impurity-F(EP);Loperamide EP Impurity F HCl;Loperamide oxide monohydrate CRS;Loperamide USP Related Compound F;Loperamide Hydrochloride Impurity F
CBNumber
CB41179066
Molecular Formula
C29H33ClN2O3
Formula Weight
493.04
MOL File
106900-12-3.mol
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Loperamide Property

solubility 
Practically insoluble in water, freely soluble in alcohol and in methylene chloride.
pka
12.94±0.20(Predicted)
Stability:
Hygroscopic
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Safety

RIDADR 
UN 2811 6.1 / PGIII
RTECS 
TM4960200
HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000341
Product name
Loperamide oxide monohydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000341
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2916
Product name
Loperamide Related Compound F
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$575
Updated
2024/03/01
Sigma-Aldrich
Product number
BP636
Product name
Loperamide N-oxide
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
25MG
Price
$273
Updated
2024/03/01
Sigma-Aldrich
Product number
1370065
Product name
Loperamide oxide monohydrate
Packaging
25mg
Price
$1490
Updated
2024/03/01
TRC
Product number
L469460
Product name
trans-LoperamideN-Oxide
Packaging
250mg
Price
$1040
Updated
2021/12/16
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Loperamide Chemical Properties,Usage,Production

Chemical Properties

White or almost white powder, slightly hygroscopic.

Uses

Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.

Uses

Labelled Loperamide oxide (LOPOX). It is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.

Definition

ChEBI: Loperamide oxide is a diarylmethane.

Loperamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Loperamide Suppliers

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106900-12-3, LoperamideRelated Search:

1-(4-CHLORO-PHENYL)-3-DIMETHYLAMINO-PROPAN-1-OL (R)-1-(4-CHLOROPHENYL)-1-PROPANOL fenpipramide 4-(4-CHLOROPHENYL)PIPERIDINE Alverine Trimethylamine N-oxide 4-(4-Chlorophenyl)piperidin-4-ol (Diphenyl-3,3 propyl)-1 phenyl-4 piperidine chlorhydrate [French] Loperamide Trimethylamine N-oxide dihydrate 2,2-DIPHENYLPROPYLAMINE HYDROCHLORIDE TRIETHYLAMINE N-OXIDE DIPHENAMID DESMETHYL LOPERAMIDE Loperamide

  • loperamide oxide
  • R 58425
  • trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide 1-oxide
  • trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide 1-oxide monohydrate
  • Loperamide EP Impurity F
  • 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide N-oxide
  • LoperaMide-d6 N-Oxide
  • Loperamide impurity-F(EP)
  • trans-Loperamide N-Oxide
  • Loperamide Impurity 6（Loperamide EP Impurity F）
  • Loperamide oxide monohydrate CRS
  • 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans-
  • Loperamide EP Impurity F/ Loperamide Related Compound F (Loperamide N-Oxide)
  • 4-[TRANS-4-(4-CHLOROPHENYL)-4-HYDROXY-1- OXIDOPIPERIDIN-1-YL]-N,N-DIMETHYL-2,2- DIPHENYLBUTANAMIDE HYDROCHLORIDE
  • Loperamide N-oxideQ: What is Loperamide N-oxide Q: What is the CAS Number of Loperamide N-oxide Q: What is the storage condition of Loperamide N-oxide Q: What are the applications of Loperamide N-oxide
  • Loperamide Related Compound F ((1r,4s)-4-(4-Chlorophenyl)-1-[4-(dimethylamino)-4-oxo-3,3-diphenylbu (1370065)
  • Loperamide Hydrochloride Impurity F
  • Loperamide EP Impurity F HCl
  • Loperamide USP Related Compound F
  • Loperamide Hydrochloride EP Impurity F
  • Loperamide EP Impurity F (Loperamide USP Related Compound F, trans-Loperamide N-Oxide)
  • 106900-12-3
  • C29H27D6ClN2O3
  • Amines
  • Drug Analogues
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Metabolites & Impurities
  • Pharmaceuticals