3-Deazauridine

Product Name: 3-Deazauridine
CAS No.: 23205-42-7
Chemical Name: 3-Deazauridine
Synonyms: NSC-126849;3-deazuridine;3-DEAZAURIDINE;3-DEAZAURIDINE CRYSTALLINE;3Deazauridine,3 Deazauridine;3-Deazauridine,anticancer antiviral;1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone;4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone;4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone;4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone
CBNumber: CB4125871
Molecular Formula: C10H13NO6
Formula Weight: 243.21
MOL File: 23205-42-7.mol

More

Less

3-Deazauridine Property

Melting point:: 233-235°C
Boiling point:: 569.2±50.0 °C(Predicted)
Density: 1.718±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
pka: 4.50±1.00(Predicted)
color: White to Pale Beige
InChI: InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3
InChIKey: CBOKZNLSFMZJJA-FNMQVXAUNA-N
SMILES: [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O |&1:0,1,3,5,r|
LogP: -1.693 (est)

More

Less

Safety

RTECS: UV1148000

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 23125
Product name: 3-Deazauridine
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23125
Product name: 3-Deazauridine
Purity: ≥98%
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 23125
Product name: 3-Deazauridine
Purity: ≥98%
Packaging: 25mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 23125
Product name: 3-Deazauridine
Purity: ≥98%
Packaging: 50mg
Price: $243
Updated: 2024/03/01

Usbiological

Product number: 007578
Product name: 3-Deazauridine
Packaging: 100mg
Price: $460
Updated: 2021/12/16

More

Less

3-Deazauridine Chemical Properties,Usage,Production

Description

3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].

Uses

Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.

Definition

ChEBI: 3-Deazauridine is a N-glycosyl compound.

References

[1] W J Moriconi, S Taylor, M Slavik. “3-Deazauridine (NSC 126849): an interesting modulator of biochemical response.” Investigational New Drugs 4 1 (1986): 67–84.
[2] W M Shannon, F M Schabel, G Arnett. “3-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro.” Antimicrobial Agents and Chemotherapy 2 3 (1972): 159–63.

3-Deazauridine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-Deazauridine Suppliers

Canada 1 China 45 Germany 1 India 1 Japan 1 South Korea 1 Switzerland 1 United Kingdom 5 United States 13 USA 1 Global 70

Zhengzhou Granlen Sciences, ltd.

Tel: 0371-85513397
Email: info@granlen.com
Country: China
ProdList: 1827
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10269
Advantage: 58

Zhengzhou GranLen pharmaceutical Technology Co., Ltd.

Tel: 0371-85513397
Email: info@granlen.com
Country: China
ProdList: 497
Advantage: 55

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4619
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

23205-42-7, 3-DeazauridineRelated Search:

N-VINYLACETAMIDE 97 N-Methylolacrylamide N,N-Dimethylacrylamide 4-DIMETHYLAMINO-1-BUTANOL 3-Methylamino-1,2-propanediol N-Methyl-N-vinylacetamide N-ETHYL ACRYLAMIDE N-(HYDROXYMETHYL)ACETAMIDE 3-Dimethylaminopropane-1,2-diol 1-Methyl-2-pyridone 3-Dimethylamino-1-propanol N,N-Dimethylallylamine 1-PROPYL-2(1H)-PYRIDINONE N-(1-ISOPROPOXYETHYL)ACETAMIDE ALLYLETHYLAMINE 3-Deazauridine 3-Acryloylamino-1-propanol solution, 50% in water N-hydroxymethyl-N-methylformamide

4-HYDROXY-1-BETA-D-RIBOFURANOSYL-2[1H]PYRIDONE

3-DEAZAURIDINE

3-deazuridine

4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinon

4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinone

4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridon

3-DEAZAURIDINE CRYSTALLINE

1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone

4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone

4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone

4-Hydroxy-1-(β-D-ribofuranosyl)-1,2-dihydropyridin-2-one

4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone

NSC-126849

4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone

1-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-2-HYDROXYPYRIDIN-4-ONE

2(1H)-Pyridinone, 4-hydroxy-1-β-D-ribofuranosyl-

3-Deazauridine, 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, 3-DAU, NSC 126849

2(1H)-Pyridinone,4-hydroxy-1-b-D-ribofuranosyl-

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxypyridin-2(1H)-one

3-Deazauridine,4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, synthetase inhibitor, anticancer drug, NSC126849, 3D2U

4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, NSC126849

3Deazauridine,3 Deazauridine

3-Deazauridine,anticancer antiviral

23205-42-7

232005-42-7

20235-47-2

C10H13NO6

Bases & Related Reagents

Heterocycles

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals