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DIETHOXYMETHANE

Product Name
DIETHOXYMETHANE
CAS No.
462-95-3
Chemical Name
DIETHOXYMETHANE
Synonyms
ETHYLAL;Methane, diethoxy-;Ethoxymethoxy-ethane;FORMALDEHYDE DIETHYL ACETAL;Ethylal >DIETHYLFORMAL;diethoxy-methan;DIETHOXYMETHANE;3,5-dioxaheptene;Diethyl methylal
CBNumber
CB4128049
Molecular Formula
C5H12O2
Formula Weight
104.15
MOL File
462-95-3.mol
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DIETHOXYMETHANE Property

Melting point:
-66.5 °C
Boiling point:
87-88 °C (lit.)
Density 
0.831 g/mL at 25 °C (lit.)
vapor density 
3.6 (vs air)
vapor pressure 
60 mm Hg ( 25 °C)
refractive index 
n20/D 1.373(lit.)
Flash point:
22 °F
storage temp. 
Store below +30°C.
solubility 
91g/l
form 
Liquid
color 
Clear colorless
Odor
Very diffusive, sweet-ethereal odor, somewhat reminiscent of Acetone and Methyl acetate
Odor Type
Sweet, ethereal, slightly fruity taste. Not very powerful
explosive limit
1.5%(V)
Water Solubility 
4.2 G/100 ML
BRN 
1697253
Dielectric constant
2.5299999999999998
Stability:
Stable. Highly flammable. Incompatible with strong oxidizing agents, strong acids.
InChIKey
KLKFAASOGCDTDT-UHFFFAOYSA-N
LogP
0.84
CAS DataBase Reference
462-95-3(CAS DataBase Reference)
NIST Chemistry Reference
Diethoxymethane(462-95-3)
EPA Substance Registry System
Ethane, 1,1'-[methylenebis(oxy)]bis- (462-95-3)
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Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38
Safety Statements 
16-26-36-9-37/39-33
RIDADR 
UN 2373 3/PG 2
WGK Germany 
2
RTECS 
PA8500000
F 
3
Autoignition Temperature
346 °F
TSCA 
Yes
HS Code 
2911 00 00
HazardClass 
3
PackingGroup 
II
Toxicity
LD50 orally in Rabbit: 3536 mg/kg LD50 dermal Rat > 16600 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14549
Product name
Formaldehyde diethyl acetal
Purity
for synthesis
Packaging
250ML
Price
$43.6
Updated
2025/07/31
Sigma-Aldrich
Product number
8.14549
Product name
Formaldehyde diethyl acetal
Purity
for synthesis
Packaging
1L
Price
$86.9
Updated
2025/07/31
Sigma-Aldrich
Product number
47675
Product name
Formaldehyde diethyl acetal
Purity
absolute, over molecular sieve (H2O ≤0.01%), ≥99.0% (GC)
Packaging
100mL
Price
$83.2
Updated
2025/07/31
Sigma-Aldrich
Product number
47675
Product name
Formaldehyde diethyl acetal
Purity
absolute, over molecular sieve (H2O ≤0.01%), ≥99.0% (GC)
Packaging
500mL
Price
$88.7
Updated
2025/07/31
TCI Chemical
Product number
D0457
Product name
Ethylal
Purity
>99.0%(GC)
Packaging
25mL
Price
$22
Updated
2025/07/31
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DIETHOXYMETHANE Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

Diethoxymethane (DEM) is offered by Eastman Chemical Company as a cost-effective replacement solvent for monoglyme (1,2- dimethoxyethane) and methylal. The DEM diether is stable under alkaline conditions, but can be cleaved by strong acids. Diethoxymethane can be used as a chemical intermediate in many organic synthesis reactions. Diethoxymethane is useful as a solvent in lithium batteries with nonaqueous electrolytes, as a solvent for polymeric materials, and as a fuel additive. As a chemical intermediate DEM can act as an ethoxymethylating reagent for alcohols and phenols and serve as a source for formaldehyde in organic synthesis.

Uses

Diethoxymethane may be used as a substitute solvent to dichloromethane and toluene in the O-alkylation of different phenols in the presence of phase transfer catalysts (PTCs).

Synthesis Reference(s)

Synthetic Communications, 25, p. 3939, 1995 DOI: 10.1080/00397919508011470

General Description

A colorless volatile liquid with an agreeable odor. Less dense than water. Flash point below 10°F. Vapors heavier than air. May be narcotic in high concentrations. Used as a solvent and in the manufacture of cosmetics.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

DIETHOXYMETHANE, an acetal, is incompatible with strong oxidizing agents and acids. Breaks down to formaldehyde and ethanol in acidic solutions.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Highly flammable

Safety Profile

Moderately toxic by ingestion. Flammable when exposed to heat or flame; can react vigorously with oxidizers. When heated to decomposition it emits acrid smoke and irritating fumes.

DIETHOXYMETHANE Preparation Products And Raw materials

Raw materials

Chloramphenicol 4-Nitroacetophenone 2-Bromoacetophenone Bromine Hexamethylenetetramine

Preparation Products

2-CHLOROMETHYL-4-NITROPHENOL (5-METHOXY-1H-PYRROLO[3,2-B]PYRIDIN-3-YL)-N,N-DIMETHYLMETHANAMINE 2-Aminopyrimidine Atropine sulfate monohydrate
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DIETHOXYMETHANE Suppliers

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View Lastest Price from DIETHOXYMETHANE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
DIETHOXYMETHANE 462-95-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
Diethoxymethane 462-95-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Diethoxymethane 462-95-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

462-95-3, DIETHOXYMETHANERelated Search:

Diethyl pimelate DIGOXIN (-)-1,4-DI-O-TOSYL-2,3-O-ISOPROPYLIDENETHREITOL Digitoxin G-STROPHANTHIN CYMARIN 2-Furaldehyde diethyl acetal Bromoacetaldehyde diethyl acetal Cholesteryl oleyl carbonate N,N-DIMETHYLFORMAMIDE DICYCLOHEXYL ACETAL 5-Nitro-2-furaldehyde diacetate 3-Chloropropionaldehyde diethylacetal HECOGENIN ACETATE 1,2:3,5-Di-O-isopropylidene-alpha-D-xylofuranose 2,2-Dichloro-1,1-diethoxyethane (Dimethylamino)diethoxymethane Liquid Diethoxymethane Polysulfide Polymer Diethyl ether

  • 1-(Ethoxymethoxy)ethane
  • 1,1’-(methylenebis(oxy))bis-ethan
  • 1,1’-[methylenebis(oxy)]bis-ethan
  • 1,1’-[methylenebis(oxy)]bis-Ethane
  • 1,1-Diethoxymethane
  • 3,5-dioxaheptene
  • Diethoxymethane, 99%, stabilized with 100ppm BHT
  • diethoxy-methan
  • Ethane, 1,1'-[methylenebis(oxy)]bis-
  • Ethane,1,1’-[methylenebis(oxy)]bis-
  • Ethoxymethoxy-ethane
  • Ethoxymethyl ethyl ether
  • ethoxymethylethylether
  • Methane, diethoxy-
  • Methylenediethylether
  • Diethoxymethane Diethylformal Formaldehyde Diethyl Acetal Methylene Glycol Diethyl Ether
  • DiethoxyMethane, 99%, pure, stabilized
  • DiethoxyMethane, 99+%, Extra Dry over Molecular Sieve, stabilized, AcroSeal
  • FORMALDEHYDE DIETHYL ACETAL (STABILISED
  • Diethoxymethane 99.7%, contains 50-150 ppm BHT as stabilizer
  • ForMaldehyde diethyl acetal, 99%+
  • Diethylformal:diethoxymethane
  • METHYLENE GLYCOL DIETHYL ETHER
  • DIETHYLFORMAL
  • DIETHOXYMETHANE
  • ETHYLAL
  • FORMALDEHYDE DIETHYL ACETAL
  • Formaldehyde diethyl acetal, 99.7%
  • FORMALDEHYDE DIETHYL ACETAL, ABS., OVER MOL. S. (H2O <0.01%)
  • Diethoxymethane,99%,stab.with100ppmBHT
  • Diethoxymethane, stabilized, 99%
  • DIETHOXYMETHANE , STABILIZED WITH 100PPM BHT
  • Diethoxymethane, Ethylal
  • DEM, Diethoxymethane, Ethylal
  • Diethoxymethane, 99%, stabilized
  • Methylenedioxydiethane
  • FORMALDEHYDE DIETHYLACETAL(RG)
  • Diethoxymethane ,99.5%
  • Diethoxymethane, stabilized, pure, 99%
  • DiethoxyMethane, stabilized, 99% 500ML
  • Ethylal &gt
  • FORMALDEHYDE DIETHYL ACETAL 1 L
  • FORMALDEHYDE DIETHYL ACETAL 250 ML
  • TIANFU-CHEM - DIETHOXYMETHANE
  • ETHYLAL For Synthesis
  • Diethyl methylal
  • DIETHOXYMETHANE (DEM) - 1 LTR
  • 462-95-3
  • CH2OC2H52
  • C2H5O2CH2
  • CH3CH2OCH2OCH2CH3
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