ChemicalBook > CAS DataBase List > Adipic dihydrazide

Adipic dihydrazide

Product Name: Adipic dihydrazide
CAS No.: 1071-93-8
Chemical Name: Adipic dihydrazide
Synonyms: ADH;ADIPIC ACID DIHYDRAZIDE;403;dihydrazide;Adipohydrazide;HEXANEDIHYDRAZIDE;ADIPYL HYDRAZIDE;WSP ADH;Adip dihydr;WLN: ZMV4VMZ
CBNumber: CB4129556
Molecular Formula: C6H14N4O2
Formula Weight: 174.2
MOL File: 1071-93-8.mol

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Adipic dihydrazide Property

Melting point:: 180-182 °C (lit.)
Boiling point:: 305.18°C (rough estimate)
Density: 1.2297 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 1.6700 (estimate)
Flash point:: 150 °C
storage temp.: -20°C
solubility: H₂O: 100 mg/mL
form: Crystalline Powder
pka: 12.93±0.35(Predicted)
color: White to slightly yellow
Water Solubility: soluble
BRN: 973863
InChIKey: IBVAQQYNSHJXBV-UHFFFAOYSA-N
LogP: -2.7 at 20℃
CAS DataBase Reference: 1071-93-8(CAS DataBase Reference)
NIST Chemistry Reference: Adipic dihydrazide(1071-93-8)
EPA Substance Registry System: Hexanedioic acid, dihydrazide (1071-93-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: AV1400000
Autoignition Temperature: 360 °C
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29280090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0638
Product name: Adipic acid dihydrazide
Purity: ≥98% (titration)
Packaging: 25g
Price: $101.79
Updated: 2025/07/31

Sigma-Aldrich

Product number: A0638
Product name: Adipic acid dihydrazide
Purity: ≥98% (titration)
Packaging: 100g
Price: $415
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.41689
Product name: Adipic dihydrazide
Purity: for synthesis
Packaging: 10g
Price: $84
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.41689
Product name: Adipic dihydrazide
Purity: for synthesis
Packaging: 50g
Price: $135
Updated: 2025/07/31

TCI Chemical

Product number: A0170
Product name: Adipic Dihydrazide
Purity: >99.0%(HPLC)
Packaging: 25g
Price: $30
Updated: 2025/07/31

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Adipic dihydrazide Chemical Properties,Usage,Production

Description

Adipic dihydrazide (ADH) is the most suitable hydrazide cross-linking agent, and ADH has been widely used in water-based paint emulsions in combination with diacetone acrylamide. ADH is weakly alkaline, and there is a possibility of agglomeration when solid ADH is added directly to the emulsion, so usually ADH should be dissolved in hot water before use.

Chemical Properties

white to slightly yellow crystalline powder

Uses

Adipic dihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air. It is also employed as a paint additive and coating additive. It is also used as an intermediate. Further, it is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which finds application in powder coating.

Uses

Adipic acid dihydrazide is a homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages. Adipic acid dihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation. Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.

Flammability and Explosibility

Non flammable

reaction suitability

reagent type: cross-linking reagent

Synthesis

141-28-6

1071-93-8

General method: 7.6 g (100.0 mmol) of solid hydrazine (H3N + NHCO2-) was mixed with adipic acid (7.3 g, 50.0 mmol) in a mortar and pestle under solvent-free conditions for 10 min, followed by a stirring reaction for 5 h at 100 °C. The structure and composition of the reaction products were confirmed by 400 MHz NMR (nuclear magnetic resonance) and elemental analysis. The analysis showed that the product was hexanedihydrazide (C6H14N4O2) with ≥96% conversion and ≥95% yield (8.27 g). Alternative method: 10 g of decane was used as solvent and the reaction conditions were adjusted to stirring at 110 °C for 12 h, followed by filtration and separation operations. The rest of the steps were the same as in the generalized method. The product was analyzed as hexanedihydrazide (C6H14N4O2) with 97% conversion and 93% yield. Substitution: 5.0 g (100.0 mmol) of hydrazine hydrate was used in place of the solid hydrazine and 10.12 g (100.0 mmol) of diethyl adipate was used in place of adipic acid. The reaction was stirred at 75 °C for 5 h under the condition of 10 g ethanol as solvent. The product was analyzed as hexanedihydrazide (C6H14N4O2) with 89% conversion and 83% yield.

References

[1] Patent: KR2015/88523, 2015, A. Location in patent: Paragraph 0128; 0137; 0148-0149
[2] Organic Syntheses, 1956, vol. 36, p. 72,Note 7
[3] Justus Liebigs Annalen der Chemie, 1929, vol. 475, p. 122
[4] Journal fuer Praktische Chemie (Leipzig), 1915, vol. <2> 91, p. 23
[5] Journal fuer Praktische Chemie (Leipzig), 1981, vol. 323, # 3, p. 360 - 366

Adipic dihydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Adipic dihydrazide manufacturers

Weifang Integratechem Co., Ltd.

Product: Adipic dihydrazide(ADH) 1071-93-8
Price: US $0.00/kg
Min. Order: 800kg
Purity: 99%
Supply Ability: 50 ton per month
Release date: 2025-08-31

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Adipic dihydrazide 1071-93-8
Price: US $0.00/Kg/Bag
Min. Order: 20KG
Purity: 99%min
Supply Ability: 20 TONS
Release date: 2021-06-21

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Adipic dihydrazide 1071-93-8
Price: US $100.00-75.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-23

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Adipic dihydrazide suppliers in China CAS NO.1071-93-8

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