ChemicalBook > CAS DataBase List > L-NORADRENALINE HYDROCHLORIDE

L-NORADRENALINE HYDROCHLORIDE

Product Name: L-NORADRENALINE HYDROCHLORIDE
CAS No.: 329-56-6
Chemical Name: L-NORADRENALINE HYDROCHLORIDE
Synonyms: aktaminhydrochloride;levophedhydrochloride;L-ARTERENOL HYDROCHLORIDE;Levarterenol hydrochloride;(-)-ARTERENOL HYDROCHLORIDE;L-NORADRENALINE HYDROCHLORIDE;L-NOREPINEPHRINE HYDROCHLORIDE;[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]azanium chloride;[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]azanium chloride;[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium chloride
CBNumber: CB4129662
Molecular Formula: C8H11NO3.ClH
Formula Weight: 205.64
MOL File: 329-56-6.mol

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L-NORADRENALINE HYDROCHLORIDE Property

Melting point:: ~150 °C (dec.)
alpha: D25 -40° (c = 6)
storage temp.: 2-8°C
solubility: Very soluble in water, slightly soluble in ethanol (96 per cent). It becomes coloured on exposure to air and light.
form: Solid
color: X-form-crystals
InChI: InChI=1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H/t8-;/m0./s1
InChIKey: FQTFHMSZCSUVEU-QRPNPIFTSA-N
SMILES: C1(O)=CC=C([C@@H](O)CN)C=C1O.[H]Cl

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Safety

Hazard Codes: T,C,F
Risk Statements: 25-34-11
Safety Statements: 45-36/37/39-26-16
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DN6475000
F: 3-8-10-23
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: LD50 orl-rat: 132 mg/kg AIPTAK 180,155,69

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: N674533
Product name: L-NorepinephrineHydrochloride
Packaging: 1g
Price: $955
Updated: 2021/12/16

ChemScene

Product number: CS-2607
Product name: Norepinephrinehydrochloride
Purity: ≥98.0%
Packaging: 500mg
Price: $65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003194
Product name: L-NORADRENALINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $179.55
Updated: 2021/12/16

1Pluschem

Product number: 1P00C15O
Product name: L-NORADRENALINE HYDROCHLORIDE
Purity: 98%
Packaging: 100mg
Price: $385
Updated: 2021/12/16

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L-NORADRENALINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White or brownish-white, crystalline powder.

Uses

Alpha-adrenoceptor agonist.

Safety Profile

Poison by ingestion,subcutaneous, and intraduodenal routes. When heated todecomposition it emits very toxic fumes of HCl and NOx.

in vivo

Norepinephrine hydrochloride can be used to induce cardiomyopathy^[5]^[6]

Induced Cardiomyopathy Model^[5]^[6]

Background

Norepinephrine hydrochloride is a potent growth factor for cardiomyocytes. Long-term infusion of subhyperbaric doses of Norepinephrine hydrochloride in animals can cause increases in myocardial mass and left ventricular wall thickness. Norepinephrine hydrochloride activates the Raf-1 kinase/MAP kinase cascade through α1- and β-adrenergic stimulation, and signaling pathways from both receptors synergistically induce cardiomyocyte hypertrophy.

Specific Modeling Methods

Rat: Spragues-Dawley rats ? adult (6 months old) ? male Administration: Continuously injected via an osmotic minipump ? 100 μg/kg/h or 200 μg/kg/h (Norepinephrine)

Modeling Indicators

Molecular changes: Left ventricular Dnmt activity ↑; ROS generation ↑; lactate dehydrogenase release ↑; dystrophin expression ↑; FHL2 protein expression ↓

Gene Expression: Expression of Dnmt1, 3a, and 3b ↑; mRNA expression of fetal genes ANP, BNP, and βMHC in left ventricle ↑

Phenotypic observation: Myocardial infarction area ↑; blood pressure continues to rise; left ventricular mass ↑; left ventricular development pressure ↓; cardiac contractility ↓. Cardiac hypertrophy.

Correlated Product(s): /

Opposite Product(s): 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)

IC 50

α1-adrenergic receptor; α2-adrenergic receptor; Beta-1 adrenergic receptor; Microbial Metabolite; Human Endogenous Metabolite

Purification Methods

Recrystallise arterenol from isoPrOH and store it in the dark as it is oxidised under light (see preceding entry). [Tullar J Am Chem Soc 70 2067 1948, Beilstein 13 III 2382.]

L-NORADRENALINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-NORADRENALINE HYDROCHLORIDE manufacturers

Guangzhou Biocar Biotechnology Co.,Ltd.

Product: L-NORADRENALINE HYDROCHLORIDE 329-56-6
Price: US $1.00/g
Min. Order: 10g
Purity: 99.5%
Supply Ability: 1000kg
Release date: 2022-01-07

Handan Tongyi New Material Technology Co., Ltd

Product: Noradrenaline Hydrochloride 329-56-6
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20ton
Release date: 2021-12-10

329-56-6, L-NORADRENALINE HYDROCHLORIDERelated Search:

Phenylephrine hydrochloride (-)-N-ISOPROPYL-L-NORADRENALINE HYDROCHLORIDE Epinephrine Hydrochloride L-NORADRENALINE HYDROCHLORIDE Norepinephrine 3,4-DIHYDROXYBENZYL ALCOHOL N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE DL-NORADRENALINE HYDROCHLORIDE PHOMOPSIN A BICUCULLINE METHYLCHLORIDE (-), [METHYL-14C] BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H] (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE CIS-(+/-)-1-(AMINOMETHYL)-3,4-DIHYDRO-3-PHENYL-1H-2-BENZOPYRAN-5,6-DIOL HYDROCHLORIDE (-)-BICUCULLINE METHCHLORIDE, 1(S),9(R) NOREPINEPHRINE HYDROCHLORIDE, DL-, [7-3H] 6-FLUORONOREPINEPHRINE HYDROCHLORIDE

L-ARTERENOL HYDROCHLORIDE

(-)-ARTERENOL HYDROCHLORIDE

L-NOREPINEPHRINE HYDROCHLORIDE

1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, hydrochloride (1:1)

L-NORADRENALINE HYDROCHLORIDE

aktaminhydrochloride

alpha-(aminomethyl)-3,4-dihydroxy-,hydrochloride,(-)-benzylalcoho

levophedhydrochloride

L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol hydrochloride

[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium chloride

[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]azanium chloride

[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]azanium chloride

Racepinephrine Hydrochloride (30 mg) ((RS)-4-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diol hydrochloride)

(R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol hydrochloride

Noradrenaline Hydrochloride / Norepinephrine Hydrochloride

Levarterenol hydrochloride

329-56-6

C8H11NO3xC4H6O6