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L-NORADRENALINE HYDROCHLORIDE

Product Name
L-NORADRENALINE HYDROCHLORIDE
CAS No.
329-56-6
Chemical Name
L-NORADRENALINE HYDROCHLORIDE
Synonyms
aktaminhydrochloride;levophedhydrochloride;L-ARTERENOL HYDROCHLORIDE;Levarterenol hydrochloride;(-)-ARTERENOL HYDROCHLORIDE;L-NORADRENALINE HYDROCHLORIDE;L-NOREPINEPHRINE HYDROCHLORIDE;[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]azanium chloride;[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]azanium chloride;[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium chloride
CBNumber
CB4129662
Molecular Formula
C8H11NO3.ClH
Formula Weight
205.64
MOL File
329-56-6.mol
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L-NORADRENALINE HYDROCHLORIDE Property

Melting point:
~150 °C (dec.)
alpha 
D25 -40° (c = 6)
storage temp. 
2-8°C
solubility 
Very soluble in water, slightly soluble in ethanol (96 per cent). It becomes coloured on exposure to air and light.
form 
Solid
color 
X-form-crystals
InChI
InChI=1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H/t8-;/m0./s1
InChIKey
FQTFHMSZCSUVEU-QRPNPIFTSA-N
SMILES
C1(O)=CC=C([C@@H](O)CN)C=C1O.[H]Cl
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Safety

Hazard Codes 
T,C,F
Risk Statements 
25-34-11
Safety Statements 
45-36/37/39-26-16
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DN6475000
F 
3-8-10-23
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 orl-rat: 132 mg/kg AIPTAK 180,155,69
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
N674533
Product name
L-NorepinephrineHydrochloride
Packaging
1g
Price
$955
Updated
2021/12/16
ChemScene
Product number
CS-2607
Product name
Norepinephrinehydrochloride
Purity
≥98.0%
Packaging
500mg
Price
$65
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003194
Product name
L-NORADRENALINE HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$179.55
Updated
2021/12/16
1Pluschem
Product number
1P00C15O
Product name
L-NORADRENALINE HYDROCHLORIDE
Purity
98%
Packaging
100mg
Price
$385
Updated
2021/12/16
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L-NORADRENALINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White or brownish-white, crystalline powder.

Uses

Alpha-adrenoceptor agonist.

Safety Profile

Poison by ingestion,subcutaneous, and intraduodenal routes. When heated todecomposition it emits very toxic fumes of HCl and NOx.

in vivo

Norepinephrine hydrochloride can be used to induce cardiomyopathy[5][6]
Induced Cardiomyopathy Model[5][6]
Background
Norepinephrine hydrochloride is a potent growth factor for cardiomyocytes. Long-term infusion of subhyperbaric doses of Norepinephrine hydrochloride in animals can cause increases in myocardial mass and left ventricular wall thickness. Norepinephrine hydrochloride activates the Raf-1 kinase/MAP kinase cascade through α1- and β-adrenergic stimulation, and signaling pathways from both receptors synergistically induce cardiomyocyte hypertrophy.
Specific Modeling Methods
Rat: Spragues-Dawley rats ? adult (6 months old) ? male Administration: Continuously injected via an osmotic minipump ? 100 μg/kg/h or 200 μg/kg/h (Norepinephrine)
Modeling Indicators
Molecular changes: Left ventricular Dnmt activity ↑; ROS generation ↑; lactate dehydrogenase release ↑; dystrophin expression ↑; FHL2 protein expression ↓
Gene Expression: Expression of Dnmt1, 3a, and 3b ↑; mRNA expression of fetal genes ANP, BNP, and βMHC in left ventricle ↑
Phenotypic observation: Myocardial infarction area ↑; blood pressure continues to rise; left ventricular mass ↑; left ventricular development pressure ↓; cardiac contractility ↓. Cardiac hypertrophy.
Correlated Product(s): /
Opposite Product(s): 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)

IC 50

α1-adrenergic receptor; α2-adrenergic receptor; Beta-1 adrenergic receptor; Microbial Metabolite; Human Endogenous Metabolite

Purification Methods

Recrystallise arterenol from isoPrOH and store it in the dark as it is oxidised under light (see preceding entry). [Tullar J Am Chem Soc 70 2067 1948, Beilstein 13 III 2382.]

L-NORADRENALINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-NORADRENALINE HYDROCHLORIDE Suppliers

China 54 Germany 1 India 2 South Korea 1 Switzerland 2 United Kingdom 2 United States 11 Global 73
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Biosynth AG
Tel
--
Fax
--
Email
welcome@biosynth.ch
Country
Switzerland
ProdList
3324
Advantage
72
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View Lastest Price from L-NORADRENALINE HYDROCHLORIDE manufacturers

Guangzhou Biocar Biotechnology Co.,Ltd.
Product
L-NORADRENALINE HYDROCHLORIDE 329-56-6
Price
US $1.00/g
Min. Order
10g
Purity
99.5%
Supply Ability
1000kg
Release date
2022-01-07
Handan Tongyi New Material Technology Co., Ltd
Product
Noradrenaline Hydrochloride 329-56-6
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20ton
Release date
2021-12-10

329-56-6, L-NORADRENALINE HYDROCHLORIDERelated Search:

Phenylephrine hydrochloride (-)-N-ISOPROPYL-L-NORADRENALINE HYDROCHLORIDE Epinephrine Hydrochloride L-NORADRENALINE HYDROCHLORIDE Norepinephrine 3,4-DIHYDROXYBENZYL ALCOHOL N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE DL-NORADRENALINE HYDROCHLORIDE PHOMOPSIN A BICUCULLINE METHYLCHLORIDE (-), [METHYL-14C] BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H] (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE CIS-(+/-)-1-(AMINOMETHYL)-3,4-DIHYDRO-3-PHENYL-1H-2-BENZOPYRAN-5,6-DIOL HYDROCHLORIDE (-)-BICUCULLINE METHCHLORIDE, 1(S),9(R) NOREPINEPHRINE HYDROCHLORIDE, DL-, [7-3H] 6-FLUORONOREPINEPHRINE HYDROCHLORIDE

  • L-ARTERENOL HYDROCHLORIDE
  • (-)-ARTERENOL HYDROCHLORIDE
  • L-NOREPINEPHRINE HYDROCHLORIDE
  • 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, hydrochloride (1:1)
  • L-NORADRENALINE HYDROCHLORIDE
  • aktaminhydrochloride
  • alpha-(aminomethyl)-3,4-dihydroxy-,hydrochloride,(-)-benzylalcoho
  • levophedhydrochloride
  • L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol hydrochloride
  • [2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium chloride
  • [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]azanium chloride
  • [2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]azanium chloride
  • Racepinephrine Hydrochloride (30 mg) ((RS)-4-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diol hydrochloride)
  • (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol hydrochloride
  • Noradrenaline Hydrochloride / Norepinephrine Hydrochloride
  • Levarterenol hydrochloride
  • 329-56-6
  • C8H11NO3xC4H6O6