2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose
- Product Name
- 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose
- CAS No.
- 97614-43-2
- Chemical Name
- 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose
- Synonyms
- D-Arabinofuranose;1,3,5-TRI-O-BENZOYL-2-DEOXY-2-FLUORO-A-D-ARABINOFURANOSE;2-DEOXY-2-FLUORO-1,3,5-TRI-O-BENZOYL-ALPHA-D-ARABINOFURANOSE;FLuorosugar;2-fluoro-2-deoxy-1;2-Deoxy-2-fluoro-1,3;InterMediate of Clofarabine;2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-α2-deoxy-2-fluoro-tribenzoyl - α - d-alarbulose;2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofur
- CBNumber
- CB4137232
- Molecular Formula
- C26H21FO7
- Formula Weight
- 464.44
- MOL File
- 97614-43-2.mol
2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose Property
- Melting point:
- 74-77°C
- Boiling point:
- 584.1±50.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in chloroform or dichloromethane
- form
- Powder
- color
- White to Off-white
- InChIKey
- JOAHVPNLVYCSAN-PPTKZWKYSA-N
- SMILES
- [C@H]1(OC(=O)C2=CC=CC=C2)[C@H](F)[C@@H](OC(=O)C2C=CC=CC=2)O[C@@H]1COC(=O)C1C=CC=CC=1 |&1:0,10,12,23,r|
- CAS DataBase Reference
- 97614-43-2(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D4594
- Product name
- 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-alpha-D-arabinofuranose
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- D4594
- Product name
- 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-alpha-D-arabinofuranose
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $124
- Updated
- 2025/07/31
- Product number
- D235500
- Product name
- 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-α-D-arabinofuranose
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 008101
- Product name
- 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-α-D-arabinofuranose|
- Packaging
- 250mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- D235500
- Product name
- 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-α-D-arabinofuranose
- Packaging
- 25g
- Price
- $120
- Updated
- 2021/12/16
2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
It is a pharmaceutical intermediate and is used as an OLED materials.
Uses
Clofarabine intermediate.
Synthesis
97614-42-1
97614-43-2
Synthesis of Compound VIII: Compound VII (2.2 mmol) was dissolved in ethyl acetate (54 mL) and triethylamine (Et3N) was added. Hydrogen trifluoride (3HF, 2.08 mL, 0.013 mmol) was added slowly under stirring. The reaction mixture was heated to 60°C with continuous stirring for 3 hours, followed by warming to 70°C with continued stirring for 1.5 hours. Upon completion of the reaction, the reaction was quenched by the addition of ice brine (10 mL) and extracted with dichloromethane. The organic phases were combined and washed sequentially with brine, water and saturated sodium bicarbonate solution and dried over anhydrous sodium sulfate for 4 hours. The solvent was removed by concentration under reduced pressure to give a dark yellow syrupy crude product. Purification by silica gel column chromatography (5 cm × 5 cm, eluted with dichloromethane) gave a light yellow syrupy product in 86.8% yield. Finally, the crude product was recrystallized in 95% ethanol to give the white crystalline compound VIII in 66.4% yield.1H NMR (CDCl3) δ ppm: 7.31-8.10 (m, 15H, OBz), 6.71 (d, J = 9.0 Hz, 1H, H-1), 5.68 (dd, J = 19.44 Hz, 1H, H-3). 5.32 (d, J = 48.2 Hz, 1H, H-2), 4.65-4.77 (m, 3H, H-4, H-5). Melting point: 80-82°C.
References
[1] Patent: EP2177527, 2010, A1. Location in patent: Page/Page column 11-12
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 1999, vol. 42, # SUPPL. 1, p. S638-S640
[3] Tetrahedron Letters, 1996, vol. 37, # 1, p. 17 - 20
2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose Preparation Products And Raw materials
Raw materials
Preparation Products
2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose Suppliers
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View Lastest Price from 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose manufacturers
- Product
- 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose 97614-43-2
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-17
- Product
- 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose 97614-43-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
- Product
- Fluorosugar 97614-43-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10