mycotrienin II
- Product Name
- mycotrienin II
- CAS No.
- 82189-04-6
- Chemical Name
- mycotrienin II
- Synonyms
- mycotrienin II;T 23II, Mycotrienin II, T 23II;20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate];D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester
- CBNumber
- CB41375521
- Molecular Formula
- C36H50N2O8
- Formula Weight
- 638.79
- MOL File
- 82189-04-6.mol
mycotrienin II Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO, DMF, Ethanol or Methanol
- form
- solid
- color
- Pale-yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 21996
- Product name
- Ansatrienin B
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $353
- Updated
- 2024/03/01
- Product number
- 21996
- Product name
- Ansatrienin B
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $1365
- Updated
- 2024/03/01
- Product number
- A678305
- Product name
- AnsatrieninB
- Packaging
- 2.5mg
- Price
- $670
- Updated
- 2021/12/16
- Product number
- API0025351
- Product name
- ANSATRIENIN B
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $640.5
- Updated
- 2021/12/16
mycotrienin II Chemical Properties,Usage,Production
Description
Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.4
Uses
Ansatrienin B, also known as Mycotrienin II and Antibiotic T 23II, was isolated from a Streptomyces sp.. Closely related to the cytotrienins and trienomycins, it displays potent activity against tumour cell lines and inhibits osteoclastic bone resorption. Ansatrienin B also significantly potentiates the action of several clinical anti-cancer agents.
in vivo
Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice[2].
References
[1] M SUGITA. Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II.[J]. Journal of Antibiotics, 1982, 35 11: 1467-1473. DOI:10.7164/antibiotics.35.1467
[2] D FEUERBACH. Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption.[J]. The Journal of Biological Chemistry, 1995, 270 43: 25949-25955. DOI:10.1074/jbc.270.43.25949
[3] YURIKO YAMADA. Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines[J]. Journal of Antibiotics, 2011, 64 5: 361-366. DOI:10.1038/ja.2011.23
mycotrienin II Preparation Products And Raw materials
Raw materials
Preparation Products
mycotrienin II Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58