mycotrienin II Property

storage temp. 

-20°C

solubility 

Soluble in DMSO, DMF, Ethanol or Methanol

form 

solid

color 

Pale-yellow

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months.

Hazard and Precautionary Statements (GHS)

mycotrienin II Chemical Properties,Usage,Production

Description

Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.4

Uses

Ansatrienin B, also known as Mycotrienin II and Antibiotic T 23II, was isolated from a Streptomyces sp.. Closely related to the cytotrienins and trienomycins, it displays potent activity against tumour cell lines and inhibits osteoclastic bone resorption. Ansatrienin B also significantly potentiates the action of several clinical anti-cancer agents.

References

1) Sugita et al. (1982), Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II; J. Antibiot. (Tokyo), 35 1467 2) Feuerbach et al. (1995), Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption; J. Biol. Chem., 270 25949 3) Yamada et al. (2011), Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines; J. Antibiot. (Tokyo), 64 361