bruceine A

ChemicalBook > CAS DataBase List > bruceine A

Product Name: bruceine A
CAS No.: 25514-31-2
Chemical Name: bruceine A
Synonyms: NSC31616;Brucein A;bruceine A;NSC 310616;Dihydrobrusatol;Brucea javanica A;Bruceine A 25514-31-2;Bruceine A (Dihydrobrusatol;13,20-Epoxy-3,11β,12α-trihydroxy-15β-(3-methyl-1-oxobutoxy)-2,16-dioxopicras-3-en-21-oic acid methyl ester;Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,15β)-
CBNumber: CB41382240
Molecular Formula: C26H34O11
Formula Weight: 522.54
MOL File: 25514-31-2.mol

Less

bruceine A Property

Boiling point:: 712.6±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥5.23 mg/mL in DMSO with gentle warming
form: Powder
pka: 8.81±0.70(Predicted)

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29936
Product name: Bruceine A
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29936
Product name: Bruceine A
Packaging: 25mg
Price: $420
Updated: 2024/03/01

Cayman Chemical

Product number: 29936
Product name: Bruceine A
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 29936
Product name: Bruceine A
Packaging: 10mg
Price: $214
Updated: 2024/03/01

TRC

Product number: B689315
Product name: BruceantinA
Packaging: 25mg
Price: $340
Updated: 2021/12/16

Less

bruceine A Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the fruit of bruce chinensis.

Uses

Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent.

Definition

ChEBI: Bruceine A is a quassinoid.

Biological Activity

ic50: 7.7 nm against the parasitescanine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, babesia gibsoni and b. canis. clinical signs of b. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. bruceine a, a natural quassinoid compound extracted from the brucea javanica (l.) merr. dried fruits, was reported to have antibabesial activity.

Physiological effects

Bruisein A has an effect of treating malignant tumor, antimalarial and anti-inflammatory.

in vitro

bruceine a inhibited the in-vitro babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nm [1].

in vivo

oral administration of bruceine a at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. an untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. however, the two bruceine a-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1].

target

Antifection | p65 | NF-kB | ROS

References

[1] nakao r, mizukami c, kawamura y, subeki, bawm s, yamasaki m, maede y, matsuura h, nabeta k, nonaka n, oku y, katakura k. evaluation of efficacy of bruceine a, a natural quassinoid compound extracted from a medicinal plant, brucea javanica, for canine babesiosis. j vet med sci. 2009 jan;71(1):33-41.

bruceine A Preparation Products And Raw materials

Raw materials

Preparation Products

Less

bruceine A Suppliers

China 109 United Kingdom 1 United States 10 Global 120

Chengdu PFID reference Technology Co., Ltd

Tel: 028-82610909 15882229804
Email: pufeide@foxmail.com
Country: China
ProdList: 2335
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5654
Advantage: 65

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Tel: 025-84430028 13815430202
Email: sale02@cqherb.com
Country: China
ProdList: 280
Advantage: 59

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
Advantage: 58

Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773
Fax: 021-61486878
Email: sales@aspirebio.com
Country: China
ProdList: 2881
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8147
Advantage: 55

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9972
Advantage: 58

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 7059
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Shanghai ChengShao Biological Technology Co., Ltd.

Tel: 021-61847300 13341622919
Fax: 021-61847300
Email: shcss01@163.com
Country: China
ProdList: 4809
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 3154
Advantage: 58

Shanghai Uteam Biotechnology Co., Ltd.

Tel: 021-36031160 13311776681
Email: 3338195766@QQ.com
Country: China
ProdList: 5175
Advantage: 55

Shanghai Biological Technology Development Co., Ltd.

Tel: 021-69955236-807 13918189704
Fax: 021-65211385
Email: chinaruji@chinaruji.com
Country: China
ProdList: 5176
Advantage: 55

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-85370565-229 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 9174
Advantage: 60

Chengdu Greenpure Biopharma CO.,Ltd

Tel: 028-88203606; 18283602253
Email: jancyzheng@gcgreenpure.com
Country: China
ProdList: 1587
Advantage: 58

Shanghai Standard Technology Co.,Ltd.

Tel: 021-57127007-6622 15618937986
Fax: +86 (21) 5132-0077
Email: zhaok@nature-standard.com
Country: China
ProdList: 3928
Advantage: 58

Shanghai Innovative Reseach Center Of Traditional

Tel: 86-21-50801717-301
Fax: 86-21-50800509
Email: wangjh@sirc-tcm.sh.cn
Country: China
ProdList: 2070
Advantage: 58

Linyi Azelasi Biological Co., Ltd.

Tel: 17753923223
Fax: 0539-6222546
Email: 2805221329@qq.com
Country: China
ProdList: 1474
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Nanjing Yuanzhi Biotechnology Co. Ltd.

Tel: 15805159960
Email: 1211550495@qq.com
Country: China
ProdList: 1793
Advantage: 58

Chengdu Glip Biotechnology Co., Ltd.

Tel: 028-87075086 18030859262
Email: 2851503756@qq.com
Country: China
ProdList: 1922
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23556
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8618339805032
Email: alfa4@alfachem.cn
Country: China
ProdList: 12975
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19994
Advantage: 58

Wuhan ChemNorm Biotech Co.,Ltd.

Tel: +86-27-8439 4403 18971486879
Fax: +86-27-8439 4403
Email: sales@chemnorm.com
Country: CHINA
ProdList: 2935
Advantage: 58

Zhejiang Lianshuo Biotechnology Co., Ltd.

Tel: 18616526224
Email: lianshuo@vip.126.com
Country: China
ProdList: 9610
Advantage: 58

Chengdu Gupte Biotechnology Co., Ltd.

Tel: 13881890404
Fax: 028-81711798
Email: 2851503757@qq.com
Country: China
ProdList: 2291
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5182
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Country: China
ProdList: 39916
Advantage: 58

Chengdu Alfa Biotechnology Co.,Ltd.

Tel: 028-028-85142057 19983342022
Fax: 028-85142057
Email: 3005359975@qq.com
Country: China
ProdList: 1970
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: chenjw@absin.cn
Country: China
ProdList: 24734
Advantage: 58

Sichuan BioCrick Biotech Co., Ltd

Tel: 28-85433893
Email: info@biocrick.com
Country: CHINA
ProdList: 4988
Advantage: 58

Neostar United (Changzhou) Industrial Co., Ltd.

Tel: +86-519-519-85557386
Fax: +0086-519-85557389
Email: marketing1@neostarunited.com
Country: China
ProdList: 8348
Advantage: 58

PCL - Business, Laboratory Pharmaceutical

Tel: 19150123681
Fax: QQ:3008022628
Email: Hu.xinyue@purechemland.com
Country: China
ProdList: 3567
Advantage: 58

Shanghai Sig Biotechnology Co., LTD

Tel: 021-57810052 18930344717
Fax: 021-57810052
Email: 2089316240@qq.com
Country: China
ProdList: 9396
Advantage: 58

Shanghai Bohu Biotechnology Co., LTD

Tel: 021-57763112 13585886131
Email: 3004987436@qq.com
Country: China
ProdList: 9694
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14092
Advantage: 58

Wuhan ChemNorm co., LTD.

Tel: 18971486879
Email: 279414929@qq.com
Country: CHINA
ProdList: 2925
Advantage: 58

ChengDu YiRui Bio-Technology CO., LTD

Tel: 17345243906 18224028459
Fax: QQ137193152
Email: tangcongxin2020@163.com
Country: China
ProdList: 1203
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7975
Advantage: 58

Less

View Lastest Price from bruceine A manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Bruceine A 25514-31-2 25514-31-2
Price: US $160.00/mg
Min. Order: 10mg
Purity: >98% by HPLC
Supply Ability: 1000.00 kgs
Release date: 2019-07-09

Career Henan Chemical Co

Product: bruceine A 25514-31-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

25514-31-2, bruceine ARelated Search:

YADANZIOSIDE-L bruceine B Acid Red 94 DEHYDROBRUCEANTIN Bruceantin (+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione bruceine E brusatol yadanziolide A YADANZIOLIDE-C (-)-13,20-Epoxy-1β,11β,12α,14,15β,21-hexahydroxypicrasa-3-ene-2,16-dione bruceine D Brucea javanicaseed oil Bruceae Fructus

bruceine A

13,20-Epoxy-3,11β,12α-trihydroxy-15β-(3-methyl-1-oxobutoxy)-2,16-dioxopicras-3-en-21-oic acid methyl ester

Dihydrobrusatol

NSC 310616

Bruceine A (Dihydrobrusatol

Bruceine A 25514-31-2

Brucea javanica A

NSC31616

Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,15β)-

Brucein A

25514-31-2

C26H34O11