(+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione
- Product Name
- (+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione
- CAS No.
- 95258-13-2
- Chemical Name
- (+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione
- Synonyms
- Yadanziolide B;(+)-Yadanziolide B;(+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione;Picras-3-ene-2,16-dione, 13,20-epoxy-1,6,11,12,14,15,21-heptahydroxy-, (1β,6α,11β,12α,15β)-
- CBNumber
- CB82396178
- Molecular Formula
- C20H26O11
- Formula Weight
- 442.41
- MOL File
- 95258-13-2.mol
(+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione Chemical Properties,Usage,Production
Uses
Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor[1][2].
Definition
ChEBI: Yadanziolide B is a quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 6, 11, 12, 14, 15 and 21 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity. It has a role as an antineoplastic agent and a plant metabolite. It is a quassinoid, a delta-lactone, an enone, an organic heteropentacyclic compound, a heptol and a secondary alpha-hydroxy ketone. It derives from a hydride of a picrasane.
References
[1] Hui Chen, et al. Indole alkaloids and quassinoids from the stems of Brucea mollis. J Nat Prod. 2011 Nov 28;74(11):2438-45. DOI:10.1021/np200712y
[2] Rina Fajri Nuwarda, et al. Molecular Docking Studies of Compounds from Brucea javanica (L.) Merr. Towards The Discovery of Potential H5N1 Neuraminidase Inhibitors. Beranda Vol 7, No 1 (2020) Nuwarda.
(+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione Preparation Products And Raw materials
Raw materials
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