bruceine A
- Product Name
- bruceine A
- CAS No.
- 25514-31-2
- Chemical Name
- bruceine A
- Synonyms
- NSC31616;Brucein A;bruceine A;NSC 310616;Dihydrobrusatol;Brucea javanica A;Bruceine A 25514-31-2;Bruceine A (Dihydrobrusatol;13,20-Epoxy-3,11β,12α-trihydroxy-15β-(3-methyl-1-oxobutoxy)-2,16-dioxopicras-3-en-21-oic acid methyl ester;Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,15β)-
- CBNumber
- CB41382240
- Molecular Formula
- C26H34O11
- Formula Weight
- 522.54
- MOL File
- 25514-31-2.mol
bruceine A Property
- Boiling point:
- 712.6±60.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥5.23 mg/mL in DMSO with gentle warming
- form
- Powder
- pka
- 8.81±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- 29936
- Product name
- Bruceine A
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29936
- Product name
- Bruceine A
- Packaging
- 25mg
- Price
- $420
- Updated
- 2024/03/01
- Product number
- 29936
- Product name
- Bruceine A
- Packaging
- 5mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- 29936
- Product name
- Bruceine A
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- B689315
- Product name
- BruceantinA
- Packaging
- 25mg
- Price
- $340
- Updated
- 2021/12/16
bruceine A Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the fruit of bruce chinensis.
Uses
Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent.
Definition
ChEBI: Bruceine A is a quassinoid.
Biological Activity
ic50: 7.7 nm against the parasitescanine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, babesia gibsoni and b. canis. clinical signs of b. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. bruceine a, a natural quassinoid compound extracted from the brucea javanica (l.) merr. dried fruits, was reported to have antibabesial activity.
Physiological effects
Bruisein A has an effect of treating malignant tumor, antimalarial and anti-inflammatory.
in vitro
bruceine a inhibited the in-vitro babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nm [1].
in vivo
oral administration of bruceine a at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. an untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. however, the two bruceine a-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1].
target
Antifection | p65 | NF-kB | ROS
References
[1] nakao r, mizukami c, kawamura y, subeki, bawm s, yamasaki m, maede y, matsuura h, nabeta k, nonaka n, oku y, katakura k. evaluation of efficacy of bruceine a, a natural quassinoid compound extracted from a medicinal plant, brucea javanica, for canine babesiosis. j vet med sci. 2009 jan;71(1):33-41.
bruceine A Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from bruceine A manufacturers
- Product
- Bruceine A 25514-31-2 25514-31-2
- Price
- US $160.00/mg
- Min. Order
- 10mg
- Purity
- >98% by HPLC
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-09
- Product
- bruceine A 25514-31-2
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23