ChemicalBook > CAS DataBase List > 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE

4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE

Product Name: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE
CAS No.: 220227-98-5
Chemical Name: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE
Synonyms: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE;Benzaldehyde, 4-hydroxy-3-(trifluoromethyl)-;4-Formyl-2-(trifluoromethyl)phenol, 5-Formyl-2-hydroxybenzotrifluoride
CBNumber: CB4138789
Molecular Formula: C8H5F3O2
Formula Weight: 190.12
MOL File: 220227-98-5.mol

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4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE Property

Melting point:: 159-163°C
Boiling point:: 224.0±35.0 °C(Predicted)
Density: 1.429±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 5.79±0.43(Predicted)
color: Light brown
Sensitive: Air Sensitive
CAS DataBase Reference: 220227-98-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36-43
Safety Statements: 26-36/37
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS013813
Product name: 4-hydroxy-3-(trifluoromethyl)benzaldehyde
Purity: AldrichCPR
Packaging: 250mg
Price: $66.1
Updated: 2025/07/31

TRC

Product number: H999900
Product name: 4-Hydroxy-3-(trifluoromethyl)benzaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H999900
Product name: 4-Hydroxy-3-(trifluoromethyl)benzaldehyde
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: X2735
Product name: 4-Hydroxy-3-(trifluoromethyl)benzaldehyde
Packaging: 1g
Price: $58
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2815-3-13
Product name: 4-Hydroxy-3-(trifluoromethyl)benzaldehyde
Packaging: 1g
Price: $140
Updated: 2021/12/16

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4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

444-30-4

220227-98-5

Step 1: 2-Trifluoromethylphenol (5.0 g, 30.86 mmol) was dissolved in trifluoroacetic acid (50 mL) with hexamethylenetetetramine (8.64 g, 61.72 mmol) and the reaction was stirred at 65°C for 18 hours. After completion of the reaction, the reaction solution was concentrated and diluted with 2N aqueous hydrochloric acid. The acidic aqueous phase was extracted twice with ethyl acetate, and the organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (Biotage FLASH 40M, silica gel column, eluent: 20% ethyl acetate/hexane) to give 2.1 g of 4-hydroxy-3-(trifluoromethyl)benzaldehyde in 36% yield. Mass spectrum (electrospray ionization) m/z: 188.9; high resolution mass spectrum (calculated value C8H5F3O2, 190.0242; measured value [ESI, M+H]+, 191.0324).

References

[1] Patent: WO2005/37807, 2005, A1. Location in patent: Page/Page column 218-219

4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE 220227-98-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2025-03-10

Career Henan Chemical Co

Product: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE 220227-98-5
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

220227-98-5, 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDERelated Search:

4-Formyl-2-(trifluoromethyl)phenol, 5-Formyl-2-hydroxybenzotrifluoride

4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE

Benzaldehyde, 4-hydroxy-3-(trifluoromethyl)-

220227-98-5

Aromatic Aldehydes & Derivatives (substituted)

pharmacetical